HEADER    HYDROLASE/INHIBITOR                     19-OCT-22   8EV5              
TITLE     NLPC B3 COVALENTLY BOUND WITH E64 INHIBITOR FRAGMENT                  
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: CLAN CA, FAMILY C40, NLPC/P60 SUPERFAMILY CYSTEINE         
COMPND   3 PEPTIDASE;                                                           
COMPND   4 CHAIN: A;                                                            
COMPND   5 ENGINEERED: YES                                                      
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: TRICHOMONAS VAGINALIS;                          
SOURCE   3 ORGANISM_TAXID: 5722;                                                
SOURCE   4 GENE: TVAG_042760;                                                   
SOURCE   5 EXPRESSION_SYSTEM: ESCHERICHIA COLI BL21(DE3);                       
SOURCE   6 EXPRESSION_SYSTEM_TAXID: 469008;                                     
SOURCE   7 EXPRESSION_SYSTEM_STRAIN: LOBSTR                                     
KEYWDS    NLPC, P60, CHAP, NLPC/P60, CYSTEINE PROTEASE, INHIBITOR, E64,         
KEYWDS   2 HYDROLASE, HYDROLASE-INHIBITOR COMPLEX                               
EXPDTA    X-RAY DIFFRACTION                                                     
AUTHOR    M.J.BARNETT,D.C.GOLDSTONE                                             
REVDAT   1   06-SEP-23 8EV5    0                                                
JRNL        AUTH   M.J.BARNETT,J.PINHEIRO,J.R.KEOWN,J.BIBOY,J.GRAY,             
JRNL        AUTH 2 I.W.LUCINESCU,W.VOLLMER,R.P.HIRT,A.SIMOES-BARBOSA,           
JRNL        AUTH 3 D.C.GOLDSTONE                                                
JRNL        TITL   NLPC/P60 PEPTIDOGLYCAN HYDROLASES OF TRICHOMONAS VAGINALIS   
JRNL        TITL 2 HAVE COMPLEMENTARY ACTIVITIES THAT EMPOWER THE PROTOZOAN TO  
JRNL        TITL 3 CONTROL HOST-PROTECTIVE LACTOBACILLI.                        
JRNL        REF    PLOS PATHOG.                  V.  19 11563 2023              
JRNL        REFN                   ESSN 1553-7374                               
JRNL        PMID   37585473                                                     
JRNL        DOI    10.1371/JOURNAL.PPAT.1011563                                 
REMARK   2                                                                      
REMARK   2 RESOLUTION.    1.65 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   PROGRAM     : REFMAC 5.8.0158                                      
REMARK   3   AUTHORS     : MURSHUDOV,SKUBAK,LEBEDEV,PANNU,STEINER,              
REMARK   3               : NICHOLLS,WINN,LONG,VAGIN                             
REMARK   3                                                                      
REMARK   3    REFINEMENT TARGET : MAXIMUM LIKELIHOOD                            
REMARK   3                                                                      
REMARK   3  DATA USED IN REFINEMENT.                                            
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 1.65                           
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 33.43                          
REMARK   3   DATA CUTOFF            (SIGMA(F)) : NULL                           
REMARK   3   COMPLETENESS FOR RANGE        (%) : 99.5                           
REMARK   3   NUMBER OF REFLECTIONS             : 12981                          
REMARK   3                                                                      
REMARK   3  FIT TO DATA USED IN REFINEMENT.                                     
REMARK   3   CROSS-VALIDATION METHOD          : THROUGHOUT                      
REMARK   3   FREE R VALUE TEST SET SELECTION  : RANDOM                          
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.172                           
REMARK   3   R VALUE            (WORKING SET) : 0.171                           
REMARK   3   FREE R VALUE                     : 0.189                           
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 5.200                           
REMARK   3   FREE R VALUE TEST SET COUNT      : 716                             
REMARK   3                                                                      
REMARK   3  FIT IN THE HIGHEST RESOLUTION BIN.                                  
REMARK   3   TOTAL NUMBER OF BINS USED           : 20                           
REMARK   3   BIN RESOLUTION RANGE HIGH       (A) : 1.65                         
REMARK   3   BIN RESOLUTION RANGE LOW        (A) : 1.69                         
REMARK   3   REFLECTION IN BIN     (WORKING SET) : 912                          
REMARK   3   BIN COMPLETENESS (WORKING+TEST) (%) : 96.29                        
REMARK   3   BIN R VALUE           (WORKING SET) : 0.3110                       
REMARK   3   BIN FREE R VALUE SET COUNT          : 48                           
REMARK   3   BIN FREE R VALUE                    : 0.2470                       
REMARK   3                                                                      
REMARK   3  NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT.                    
REMARK   3   PROTEIN ATOMS            : 835                                     
REMARK   3   NUCLEIC ACID ATOMS       : 0                                       
REMARK   3   HETEROGEN ATOMS          : 14                                      
REMARK   3   SOLVENT ATOMS            : 64                                      
REMARK   3                                                                      
REMARK   3  B VALUES.                                                           
REMARK   3   FROM WILSON PLOT           (A**2) : 18.45                          
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 17.98                          
REMARK   3   OVERALL ANISOTROPIC B VALUE.                                       
REMARK   3    B11 (A**2) : -0.36000                                             
REMARK   3    B22 (A**2) : -0.36000                                             
REMARK   3    B33 (A**2) : 0.72000                                              
REMARK   3    B12 (A**2) : 0.00000                                              
REMARK   3    B13 (A**2) : 0.00000                                              
REMARK   3    B23 (A**2) : 0.00000                                              
REMARK   3                                                                      
REMARK   3  ESTIMATED OVERALL COORDINATE ERROR.                                 
REMARK   3   ESU BASED ON R VALUE                            (A): 0.092         
REMARK   3   ESU BASED ON FREE R VALUE                       (A): 0.085         
REMARK   3   ESU BASED ON MAXIMUM LIKELIHOOD                 (A): 0.060         
REMARK   3   ESU FOR B VALUES BASED ON MAXIMUM LIKELIHOOD (A**2): 1.815         
REMARK   3                                                                      
REMARK   3 CORRELATION COEFFICIENTS.                                            
REMARK   3   CORRELATION COEFFICIENT FO-FC      : 0.965                         
REMARK   3   CORRELATION COEFFICIENT FO-FC FREE : 0.971                         
REMARK   3                                                                      
REMARK   3  RMS DEVIATIONS FROM IDEAL VALUES        COUNT    RMS    WEIGHT      
REMARK   3   BOND LENGTHS REFINED ATOMS        (A):   897 ; 0.009 ; 0.019       
REMARK   3   BOND LENGTHS OTHERS               (A):   795 ; 0.002 ; 0.020       
REMARK   3   BOND ANGLES REFINED ATOMS   (DEGREES):  1216 ; 1.293 ; 1.958       
REMARK   3   BOND ANGLES OTHERS          (DEGREES):  1850 ; 0.929 ; 3.001       
REMARK   3   TORSION ANGLES, PERIOD 1    (DEGREES):   126 ; 5.919 ; 5.000       
REMARK   3   TORSION ANGLES, PERIOD 2    (DEGREES):    34 ;34.453 ;22.647       
REMARK   3   TORSION ANGLES, PERIOD 3    (DEGREES):   135 ;10.828 ;15.000       
REMARK   3   TORSION ANGLES, PERIOD 4    (DEGREES):     5 ;10.789 ;15.000       
REMARK   3   CHIRAL-CENTER RESTRAINTS       (A**3):   126 ; 0.074 ; 0.200       
REMARK   3   GENERAL PLANES REFINED ATOMS      (A):  1040 ; 0.006 ; 0.020       
REMARK   3   GENERAL PLANES OTHERS             (A):   190 ; 0.001 ; 0.020       
REMARK   3   NON-BONDED CONTACTS REFINED ATOMS (A):  NULL ;  NULL ;  NULL       
REMARK   3   NON-BONDED CONTACTS OTHERS        (A):  NULL ;  NULL ;  NULL       
REMARK   3   NON-BONDED TORSION REFINED ATOMS  (A):  NULL ;  NULL ;  NULL       
REMARK   3   NON-BONDED TORSION OTHERS         (A):  NULL ;  NULL ;  NULL       
REMARK   3   H-BOND (X...Y) REFINED ATOMS      (A):  NULL ;  NULL ;  NULL       
REMARK   3   H-BOND (X...Y) OTHERS             (A):  NULL ;  NULL ;  NULL       
REMARK   3   POTENTIAL METAL-ION REFINED ATOMS (A):  NULL ;  NULL ;  NULL       
REMARK   3   POTENTIAL METAL-ION OTHERS        (A):  NULL ;  NULL ;  NULL       
REMARK   3   SYMMETRY VDW REFINED ATOMS        (A):  NULL ;  NULL ;  NULL       
REMARK   3   SYMMETRY VDW OTHERS               (A):  NULL ;  NULL ;  NULL       
REMARK   3   SYMMETRY H-BOND REFINED ATOMS     (A):  NULL ;  NULL ;  NULL       
REMARK   3   SYMMETRY H-BOND OTHERS            (A):  NULL ;  NULL ;  NULL       
REMARK   3   SYMMETRY METAL-ION REFINED ATOMS  (A):  NULL ;  NULL ;  NULL       
REMARK   3   SYMMETRY METAL-ION OTHERS         (A):  NULL ;  NULL ;  NULL       
REMARK   3                                                                      
REMARK   3  ISOTROPIC THERMAL FACTOR RESTRAINTS.     COUNT   RMS    WEIGHT      
REMARK   3   MAIN-CHAIN BOND REFINED ATOMS  (A**2):   471 ; 1.052 ; 1.738       
REMARK   3   MAIN-CHAIN BOND OTHER ATOMS    (A**2):   470 ; 1.050 ; 1.737       
REMARK   3   MAIN-CHAIN ANGLE REFINED ATOMS (A**2):   590 ; 1.691 ; 2.602       
REMARK   3   MAIN-CHAIN ANGLE OTHER ATOMS   (A**2):   591 ; 1.691 ; 2.603       
REMARK   3   SIDE-CHAIN BOND REFINED ATOMS  (A**2):   426 ; 1.422 ; 1.965       
REMARK   3   SIDE-CHAIN BOND OTHER ATOMS    (A**2):   420 ; 1.398 ; 1.929       
REMARK   3   SIDE-CHAIN ANGLE REFINED ATOMS (A**2):  NULL ;  NULL ;  NULL       
REMARK   3   SIDE-CHAIN ANGLE OTHER ATOMS   (A**2):   614 ; 2.063 ; 2.835       
REMARK   3   LONG RANGE B REFINED ATOMS     (A**2):   971 ; 3.522 ;20.732       
REMARK   3   LONG RANGE B OTHER ATOMS       (A**2):   970 ; 3.520 ;20.690       
REMARK   3                                                                      
REMARK   3 ANISOTROPIC THERMAL FACTOR RESTRAINTS.    COUNT   RMS   WEIGHT       
REMARK   3   RIGID-BOND RESTRAINTS          (A**2):  NULL ;  NULL ;  NULL       
REMARK   3   SPHERICITY; FREE ATOMS         (A**2):  NULL ;  NULL ;  NULL       
REMARK   3   SPHERICITY; BONDED ATOMS       (A**2):  NULL ;  NULL ;  NULL       
REMARK   3                                                                      
REMARK   3  NCS RESTRAINTS STATISTICS                                           
REMARK   3   NUMBER OF DIFFERENT NCS GROUPS : NULL                              
REMARK   3                                                                      
REMARK   3  TLS DETAILS                                                         
REMARK   3   NUMBER OF TLS GROUPS  : NULL                                       
REMARK   3                                                                      
REMARK   3  BULK SOLVENT MODELLING.                                             
REMARK   3   METHOD USED : MASK                                                 
REMARK   3   PARAMETERS FOR MASK CALCULATION                                    
REMARK   3   VDW PROBE RADIUS   : 1.20                                          
REMARK   3   ION PROBE RADIUS   : 0.80                                          
REMARK   3   SHRINKAGE RADIUS   : 0.80                                          
REMARK   3                                                                      
REMARK   3  OTHER REFINEMENT REMARKS: HYDROGENS HAVE BEEN ADDED IN THE RIDING   
REMARK   3  POSITIONS                                                           
REMARK   4                                                                      
REMARK   4 8EV5 COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 24-OCT-22.                  
REMARK 100 THE DEPOSITION ID IS D_1000269437.                                   
REMARK 200                                                                      
REMARK 200 EXPERIMENTAL DETAILS                                                 
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION                  
REMARK 200  DATE OF DATA COLLECTION        : 27-AUG-16                          
REMARK 200  TEMPERATURE           (KELVIN) : 100                                
REMARK 200  PH                             : 8.5                                
REMARK 200  NUMBER OF CRYSTALS USED        : 1                                  
REMARK 200                                                                      
REMARK 200  SYNCHROTRON              (Y/N) : Y                                  
REMARK 200  RADIATION SOURCE               : AUSTRALIAN SYNCHROTRON             
REMARK 200  BEAMLINE                       : MX1                                
REMARK 200  X-RAY GENERATOR MODEL          : NULL                               
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M                                  
REMARK 200  WAVELENGTH OR RANGE        (A) : 0.9537                             
REMARK 200  MONOCHROMATOR                  : NULL                               
REMARK 200  OPTICS                         : NULL                               
REMARK 200                                                                      
REMARK 200  DETECTOR TYPE                  : CCD                                
REMARK 200  DETECTOR MANUFACTURER          : ADSC QUANTUM 315                   
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : XDS                                
REMARK 200  DATA SCALING SOFTWARE          : AIMLESS                            
REMARK 200                                                                      
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 13697                              
REMARK 200  RESOLUTION RANGE HIGH      (A) : 1.650                              
REMARK 200  RESOLUTION RANGE LOW       (A) : 33.430                             
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : NULL                               
REMARK 200                                                                      
REMARK 200 OVERALL.                                                             
REMARK 200  COMPLETENESS FOR RANGE     (%) : 99.6                               
REMARK 200  DATA REDUNDANCY                : 2.000                              
REMARK 200  R MERGE                    (I) : 0.01579                            
REMARK 200  R SYM                      (I) : NULL                               
REMARK 200  <I/SIGMA(I)> FOR THE DATA SET  : 14.3000                            
REMARK 200                                                                      
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.                                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 1.65                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 1.71                     
REMARK 200  COMPLETENESS FOR SHELL     (%) : 95.7                               
REMARK 200  DATA REDUNDANCY IN SHELL       : 2.00                               
REMARK 200  R MERGE FOR SHELL          (I) : 0.29590                            
REMARK 200  R SYM FOR SHELL            (I) : NULL                               
REMARK 200  <I/SIGMA(I)> FOR SHELL         : 2.010                              
REMARK 200                                                                      
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH                              
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT        
REMARK 200 SOFTWARE USED: PHASER                                                
REMARK 200 STARTING MODEL: NULL                                                 
REMARK 200                                                                      
REMARK 200 REMARK: NULL                                                         
REMARK 280                                                                      
REMARK 280 CRYSTAL                                                              
REMARK 280 SOLVENT CONTENT, VS   (%): 37.89                                     
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 1.98                     
REMARK 280                                                                      
REMARK 280 CRYSTALLIZATION CONDITIONS: 1.26 M AMMONIUM SULFATE, 0.1 M TRIS PH   
REMARK 280  8.5., VAPOR DIFFUSION, SITTING DROP, TEMPERATURE 291.15K            
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY                                            
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 41 21 2                        
REMARK 290                                                                      
REMARK 290      SYMOP   SYMMETRY                                                
REMARK 290     NNNMMM   OPERATOR                                                
REMARK 290       1555   X,Y,Z                                                   
REMARK 290       2555   -X,-Y,Z+1/2                                             
REMARK 290       3555   -Y+1/2,X+1/2,Z+1/4                                      
REMARK 290       4555   Y+1/2,-X+1/2,Z+3/4                                      
REMARK 290       5555   -X+1/2,Y+1/2,-Z+1/4                                     
REMARK 290       6555   X+1/2,-Y+1/2,-Z+3/4                                     
REMARK 290       7555   Y,X,-Z                                                  
REMARK 290       8555   -Y,-X,-Z+1/2                                            
REMARK 290                                                                      
REMARK 290     WHERE NNN -> OPERATOR NUMBER                                     
REMARK 290           MMM -> TRANSLATION VECTOR                                  
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS                            
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM             
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY                
REMARK 290 RELATED MOLECULES.                                                   
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   2  0.000000 -1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   2  0.000000  0.000000  1.000000       90.43900            
REMARK 290   SMTRY1   3  0.000000 -1.000000  0.000000       17.01000            
REMARK 290   SMTRY2   3  1.000000  0.000000  0.000000       17.01000            
REMARK 290   SMTRY3   3  0.000000  0.000000  1.000000       45.21950            
REMARK 290   SMTRY1   4  0.000000  1.000000  0.000000       17.01000            
REMARK 290   SMTRY2   4 -1.000000  0.000000  0.000000       17.01000            
REMARK 290   SMTRY3   4  0.000000  0.000000  1.000000      135.65850            
REMARK 290   SMTRY1   5 -1.000000  0.000000  0.000000       17.01000            
REMARK 290   SMTRY2   5  0.000000  1.000000  0.000000       17.01000            
REMARK 290   SMTRY3   5  0.000000  0.000000 -1.000000       45.21950            
REMARK 290   SMTRY1   6  1.000000  0.000000  0.000000       17.01000            
REMARK 290   SMTRY2   6  0.000000 -1.000000  0.000000       17.01000            
REMARK 290   SMTRY3   6  0.000000  0.000000 -1.000000      135.65850            
REMARK 290   SMTRY1   7  0.000000  1.000000  0.000000        0.00000            
REMARK 290   SMTRY2   7  1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY3   7  0.000000  0.000000 -1.000000        0.00000            
REMARK 290   SMTRY1   8  0.000000 -1.000000  0.000000        0.00000            
REMARK 290   SMTRY2   8 -1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY3   8  0.000000  0.000000 -1.000000       90.43900            
REMARK 290                                                                      
REMARK 290 REMARK: NULL                                                         
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1                                                       
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC                         
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A                                     
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     GLY A    13                                                      
REMARK 465     PRO A    14                                                      
REMARK 465     GLY A    15                                                      
REMARK 465     HIS A    16                                                      
REMARK 465     GLU A    17                                                      
REMARK 465     ARG A    18                                                      
REMARK 465     ARG A    19                                                      
REMARK 465     GLU A    20                                                      
REMARK 465     VAL A    21                                                      
REMARK 465     PRO A    22                                                      
REMARK 470                                                                      
REMARK 470 MISSING ATOM                                                         
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;           
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;          
REMARK 470 I=INSERTION CODE):                                                   
REMARK 470   M RES CSSEQI  ATOMS                                                
REMARK 470     LYS A  74    CE   NZ                                             
REMARK 470     ARG A  78    NE   CZ   NH1  NH2                                  
REMARK 470     LYS A 123    CD   CE   NZ                                        
REMARK 470     LYS A 128    CE   NZ                                             
REMARK 610                                                                      
REMARK 610 MISSING HETEROATOM                                                   
REMARK 610 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;           
REMARK 610 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;          
REMARK 610 I=INSERTION CODE):                                                   
REMARK 610   M RES C SSEQI                                                      
REMARK 610     E64 A  201                                                       
DBREF  8EV5 A   16   137  UNP    A2FQ38   A2FQ38_TRIVA    16    137             
SEQADV 8EV5 GLY A   13  UNP  A2FQ38              EXPRESSION TAG                 
SEQADV 8EV5 PRO A   14  UNP  A2FQ38              EXPRESSION TAG                 
SEQADV 8EV5 GLY A   15  UNP  A2FQ38              EXPRESSION TAG                 
SEQRES   1 A  125  GLY PRO GLY HIS GLU ARG ARG GLU VAL PRO ASN ALA SER          
SEQRES   2 A  125  GLY SER ALA ILE LEU ASN VAL ALA LYS SER ARG ILE GLY          
SEQRES   3 A  125  LYS GLN TYR MET SER GLY GLY THR GLY PRO ASP LEU PHE          
SEQRES   4 A  125  ASP CYS SER GLY LEU VAL LEU TYR SER HIS ASN GLN CYS          
SEQRES   5 A  125  GLY VAL TYR GLY VAL PRO ARG VAL ALA LYS ASP GLN ALA          
SEQRES   6 A  125  ARG GLY GLY LYS ALA GLY SER GLY ALA ALA GLY ASP VAL          
SEQRES   7 A  125  VAL TYR PHE GLY ASN PRO ALA HIS HIS VAL GLY ILE CYS          
SEQRES   8 A  125  CYS GLY ASP GLY SER MET VAL HIS ALA PRO ARG PRO GLY          
SEQRES   9 A  125  LYS THR VAL CYS ILE LEU LYS ILE ALA TYR MET LYS GLU          
SEQRES  10 A  125  SER TYR GLY TYR ARG ARG TYR TYR                              
HET    E64  A 201       9                                                       
HET    SO4  A 202       5                                                       
HETNAM     E64 N-[N-[1-HYDROXYCARBOXYETHYL-CARBONYL]LEUCYLAMINO-                
HETNAM   2 E64  BUTYL]-GUANIDINE                                                
HETNAM     SO4 SULFATE ION                                                      
FORMUL   2  E64    C15 H30 N5 O5 1+                                             
FORMUL   3  SO4    O4 S 2-                                                      
FORMUL   4  HOH   *64(H2 O)                                                     
HELIX    1 AA1 ASN A   23  ARG A   36  1                                  14    
HELIX    2 AA2 ASP A   52  CYS A   64  1                                  13    
HELIX    3 AA3 VAL A   72  ALA A   77  1                                   6    
HELIX    4 AA4 ALA A  125  LYS A  128  5                                   4    
SHEET    1 AA1 2 GLN A  40  TYR A  41  0                                        
SHEET    2 AA1 2 LEU A  50  PHE A  51  1  O  PHE A  51   N  GLN A  40           
SHEET    1 AA2 6 LYS A  81  ALA A  82  0                                        
SHEET    2 AA2 6 TYR A 131  ARG A 135 -1  O  ARG A 135   N  LYS A  81           
SHEET    3 AA2 6 VAL A  90  PHE A  93 -1  N  VAL A  90   O  ARG A 134           
SHEET    4 AA2 6 HIS A  99  CYS A 103 -1  O  GLY A 101   N  VAL A  91           
SHEET    5 AA2 6 SER A 108  HIS A 111 -1  O  VAL A 110   N  ILE A 102           
SHEET    6 AA2 6 CYS A 120  LYS A 123 -1  O  CYS A 120   N  HIS A 111           
LINK         SG  CYS A  53                 C2  E64 A 201     1555   1555  1.81  
CISPEP   1 GLY A   47    PRO A   48          0         8.07                     
CISPEP   2 ASN A   95    PRO A   96          0         7.17                     
CRYST1   34.020   34.020  180.878  90.00  90.00  90.00 P 41 21 2     8          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      0.029395  0.000000  0.000000        0.00000                         
SCALE2      0.000000  0.029395  0.000000        0.00000                         
SCALE3      0.000000  0.000000  0.005529        0.00000                         
ATOM      1  N   ASN A  23       1.556  -4.892 190.794  1.00 35.37           N  
ATOM      2  CA  ASN A  23       0.635  -5.764 191.585  1.00 32.79           C  
ATOM      3  C   ASN A  23       0.979  -5.721 193.075  1.00 30.31           C  
ATOM      4  O   ASN A  23       2.162  -5.830 193.456  1.00 27.60           O  
ATOM      5  CB  ASN A  23       0.692  -7.211 191.082  1.00 35.14           C  
ATOM      6  CG  ASN A  23      -0.199  -8.143 191.882  1.00 37.40           C  
ATOM      7  OD1 ASN A  23       0.134  -8.526 193.000  1.00 39.10           O  
ATOM      8  ND2 ASN A  23      -1.333  -8.514 191.313  1.00 38.63           N  
ATOM      9  N   ALA A  24      -0.060  -5.626 193.907  1.00 27.29           N  
ATOM     10  CA  ALA A  24       0.113  -5.478 195.359  1.00 25.39           C  
ATOM     11  C   ALA A  24       0.719  -6.700 196.046  1.00 22.98           C  
ATOM     12  O   ALA A  24       1.600  -6.529 196.886  1.00 20.10           O  
ATOM     13  CB  ALA A  24      -1.200  -5.093 196.025  1.00 26.25           C  
ATOM     14  N   SER A  25       0.266  -7.921 195.711  1.00 21.04           N  
ATOM     15  CA  SER A  25       0.862  -9.141 196.293  1.00 20.69           C  
ATOM     16  C   SER A  25       2.316  -9.276 195.897  1.00 17.36           C  
ATOM     17  O   SER A  25       3.144  -9.662 196.708  1.00 18.03           O  
ATOM     18  CB  SER A  25       0.114 -10.417 195.880  1.00 22.35           C  
ATOM     19  OG  SER A  25      -1.040 -10.581 196.686  1.00 27.68           O  
ATOM     20  N   GLY A  26       2.606  -8.959 194.642  1.00 15.83           N  
ATOM     21  CA  GLY A  26       3.974  -8.975 194.142  1.00 14.99           C  
ATOM     22  C   GLY A  26       4.862  -8.037 194.925  1.00 14.93           C  
ATOM     23  O   GLY A  26       5.940  -8.425 195.395  1.00 14.16           O  
ATOM     24  N   SER A  27       4.396  -6.793 195.079  1.00 14.12           N  
ATOM     25  CA ASER A  27       5.131  -5.801 195.869  0.60 14.40           C  
ATOM     26  CA BSER A  27       5.122  -5.795 195.870  0.40 14.28           C  
ATOM     27  C   SER A  27       5.318  -6.255 197.321  1.00 13.64           C  
ATOM     28  O   SER A  27       6.348  -5.980 197.929  1.00 13.50           O  
ATOM     29  CB ASER A  27       4.430  -4.438 195.827  0.60 14.49           C  
ATOM     30  CB BSER A  27       4.394  -4.445 195.840  0.40 14.37           C  
ATOM     31  OG ASER A  27       4.496  -3.885 194.525  0.60 14.91           O  
ATOM     32  OG BSER A  27       5.179  -3.426 196.433  0.40 14.74           O  
ATOM     33  N   ALA A  28       4.320  -6.940 197.876  1.00 13.39           N  
ATOM     34  CA  ALA A  28       4.408  -7.449 199.234  1.00 12.75           C  
ATOM     35  C   ALA A  28       5.551  -8.475 199.404  1.00 12.49           C  
ATOM     36  O   ALA A  28       6.358  -8.400 200.333  1.00 10.85           O  
ATOM     37  CB  ALA A  28       3.075  -8.028 199.685  1.00 13.57           C  
ATOM     38  N   ILE A  29       5.593  -9.426 198.488  1.00 11.93           N  
ATOM     39  CA  ILE A  29       6.663 -10.454 198.462  1.00 12.03           C  
ATOM     40  C   ILE A  29       8.034  -9.780 198.356  1.00 11.86           C  
ATOM     41  O   ILE A  29       8.975 -10.133 199.081  1.00 11.03           O  
ATOM     42  CB  ILE A  29       6.409 -11.407 197.290  1.00 12.15           C  
ATOM     43  CG1 ILE A  29       5.127 -12.206 197.578  1.00 12.78           C  
ATOM     44  CG2 ILE A  29       7.596 -12.351 197.029  1.00 12.89           C  
ATOM     45  CD1 ILE A  29       4.518 -12.798 196.330  1.00 13.11           C  
ATOM     46  N   LEU A  30       8.133  -8.802 197.461  1.00 11.54           N  
ATOM     47  CA  LEU A  30       9.375  -8.023 197.360  1.00 11.64           C  
ATOM     48  C   LEU A  30       9.731  -7.303 198.651  1.00 11.66           C  
ATOM     49  O   LEU A  30      10.871  -7.310 199.057  1.00 11.15           O  
ATOM     50  CB  LEU A  30       9.301  -7.042 196.199  1.00 11.96           C  
ATOM     51  CG  LEU A  30      10.497  -6.099 196.087  1.00 12.27           C  
ATOM     52  CD1 LEU A  30      11.780  -6.870 195.802  1.00 12.86           C  
ATOM     53  CD2 LEU A  30      10.206  -5.049 195.060  1.00 12.91           C  
ATOM     54  N   ASN A  31       8.753  -6.656 199.274  1.00 11.97           N  
ATOM     55  CA  ASN A  31       9.021  -5.954 200.529  1.00 12.35           C  
ATOM     56  C   ASN A  31       9.474  -6.910 201.632  1.00 11.97           C  
ATOM     57  O   ASN A  31      10.365  -6.569 202.398  1.00 12.16           O  
ATOM     58  CB  ASN A  31       7.826  -5.096 200.969  1.00 13.24           C  
ATOM     59  CG  ASN A  31       7.863  -3.720 200.342  1.00 14.31           C  
ATOM     60  OD1 ASN A  31       8.704  -2.891 200.703  1.00 15.54           O  
ATOM     61  ND2 ASN A  31       7.024  -3.493 199.342  1.00 15.02           N  
ATOM     62  N   VAL A  32       8.895  -8.110 201.716  1.00 11.41           N  
ATOM     63  CA  VAL A  32       9.399  -9.072 202.680  1.00 11.45           C  
ATOM     64  C   VAL A  32      10.846  -9.487 202.353  1.00 11.43           C  
ATOM     65  O   VAL A  32      11.710  -9.533 203.244  1.00 11.83           O  
ATOM     66  CB  VAL A  32       8.492 -10.304 202.815  1.00 11.44           C  
ATOM     67  CG1 VAL A  32       9.143 -11.317 203.743  1.00 11.44           C  
ATOM     68  CG2 VAL A  32       7.138  -9.870 203.352  1.00 11.92           C  
ATOM     69  N   ALA A  33      11.138  -9.739 201.081  1.00 11.24           N  
ATOM     70  CA  ALA A  33      12.501 -10.083 200.694  1.00 11.38           C  
ATOM     71  C   ALA A  33      13.490  -8.971 201.049  1.00 11.53           C  
ATOM     72  O   ALA A  33      14.550  -9.233 201.618  1.00 11.70           O  
ATOM     73  CB  ALA A  33      12.601 -10.428 199.213  1.00 11.07           C  
ATOM     74  N   LYS A  34      13.139  -7.737 200.707  1.00 12.28           N  
ATOM     75  CA ALYS A  34      13.979  -6.592 201.043  0.75 12.94           C  
ATOM     76  CA BLYS A  34      13.988  -6.585 201.038  0.25 12.34           C  
ATOM     77  C   LYS A  34      14.241  -6.479 202.547  1.00 12.12           C  
ATOM     78  O   LYS A  34      15.332  -6.091 202.973  1.00 12.32           O  
ATOM     79  CB ALYS A  34      13.360  -5.299 200.538  0.75 13.98           C  
ATOM     80  CB BLYS A  34      13.398  -5.269 200.508  0.25 12.59           C  
ATOM     81  CG ALYS A  34      13.446  -5.151 199.033  0.75 15.27           C  
ATOM     82  CG BLYS A  34      13.570  -5.072 199.008  0.25 12.87           C  
ATOM     83  CD ALYS A  34      12.767  -3.894 198.543  0.75 16.92           C  
ATOM     84  CD BLYS A  34      13.314  -3.639 198.554  0.25 13.16           C  
ATOM     85  CE ALYS A  34      13.234  -3.516 197.145  0.75 18.33           C  
ATOM     86  CE BLYS A  34      14.414  -2.675 198.971  0.25 13.51           C  
ATOM     87  NZ ALYS A  34      12.756  -2.159 196.779  0.75 19.47           N  
ATOM     88  NZ BLYS A  34      14.426  -1.432 198.143  0.25 13.64           N  
ATOM     89  N   SER A  35      13.242  -6.808 203.349  1.00 12.10           N  
ATOM     90  CA  SER A  35      13.366  -6.704 204.808  1.00 12.23           C  
ATOM     91  C   SER A  35      14.484  -7.589 205.357  1.00 12.05           C  
ATOM     92  O   SER A  35      14.969  -7.368 206.473  1.00 11.87           O  
ATOM     93  CB  SER A  35      12.039  -7.049 205.498  1.00 12.19           C  
ATOM     94  OG  SER A  35      11.822  -8.457 205.543  1.00 11.90           O  
ATOM     95  N   ARG A  36      14.810  -8.652 204.619  1.00 12.52           N  
ATOM     96  CA  ARG A  36      15.870  -9.568 204.990  1.00 12.54           C  
ATOM     97  C   ARG A  36      17.275  -9.175 204.498  1.00 13.32           C  
ATOM     98  O   ARG A  36      18.222  -9.933 204.694  1.00 13.91           O  
ATOM     99  CB  ARG A  36      15.545 -10.977 204.463  1.00 12.81           C  
ATOM    100  CG  ARG A  36      14.202 -11.548 204.943  1.00 13.03           C  
ATOM    101  CD  ARG A  36      14.113 -11.576 206.458  1.00 13.20           C  
ATOM    102  NE  ARG A  36      13.415 -10.438 207.024  1.00 12.49           N  
ATOM    103  CZ  ARG A  36      13.187 -10.265 208.327  1.00 13.59           C  
ATOM    104  NH1 ARG A  36      12.455  -9.237 208.747  1.00 13.69           N  
ATOM    105  NH2 ARG A  36      13.639 -11.127 209.226  1.00 13.73           N  
ATOM    106  N   ILE A  37      17.417  -8.035 203.829  1.00 14.04           N  
ATOM    107  CA  ILE A  37      18.744  -7.594 203.365  1.00 14.18           C  
ATOM    108  C   ILE A  37      19.682  -7.468 204.561  1.00 14.89           C  
ATOM    109  O   ILE A  37      19.318  -6.884 205.573  1.00 14.99           O  
ATOM    110  CB  ILE A  37      18.673  -6.283 202.551  1.00 14.94           C  
ATOM    111  CG1 ILE A  37      18.005  -6.578 201.195  1.00 14.62           C  
ATOM    112  CG2 ILE A  37      20.083  -5.663 202.358  1.00 14.71           C  
ATOM    113  CD1 ILE A  37      17.460  -5.347 200.489  1.00 15.32           C  
ATOM    114  N   GLY A  38      20.864  -8.076 204.443  1.00 14.83           N  
ATOM    115  CA  GLY A  38      21.856  -8.091 205.514  1.00 16.33           C  
ATOM    116  C   GLY A  38      21.869  -9.361 206.335  1.00 17.06           C  
ATOM    117  O   GLY A  38      22.819  -9.609 207.082  1.00 17.43           O  
ATOM    118  N   LYS A  39      20.828 -10.190 206.217  1.00 17.35           N  
ATOM    119  CA  LYS A  39      20.826 -11.469 206.928  1.00 16.74           C  
ATOM    120  C   LYS A  39      21.836 -12.457 206.319  1.00 17.30           C  
ATOM    121  O   LYS A  39      22.070 -12.483 205.091  1.00 16.52           O  
ATOM    122  CB  LYS A  39      19.429 -12.088 206.953  1.00 16.87           C  
ATOM    123  CG  LYS A  39      18.364 -11.267 207.662  1.00 17.14           C  
ATOM    124  CD  LYS A  39      18.604 -11.059 209.142  1.00 17.32           C  
ATOM    125  CE  LYS A  39      17.332 -10.546 209.774  1.00 18.26           C  
ATOM    126  NZ  LYS A  39      17.569 -10.012 211.129  1.00 19.45           N  
ATOM    127  N   GLN A  40      22.421 -13.274 207.181  1.00 18.57           N  
ATOM    128  CA AGLN A  40      23.507 -14.173 206.766  0.60 19.94           C  
ATOM    129  CA BGLN A  40      23.507 -14.190 206.780  0.40 19.71           C  
ATOM    130  C   GLN A  40      22.984 -15.364 205.973  1.00 20.65           C  
ATOM    131  O   GLN A  40      21.858 -15.824 206.177  1.00 19.09           O  
ATOM    132  CB AGLN A  40      24.299 -14.660 207.983  0.60 22.02           C  
ATOM    133  CB BGLN A  40      24.281 -14.726 207.998  0.40 21.01           C  
ATOM    134  CG AGLN A  40      24.939 -13.549 208.820  0.60 22.81           C  
ATOM    135  CG BGLN A  40      25.479 -13.883 208.414  0.40 21.45           C  
ATOM    136  CD AGLN A  40      26.135 -12.881 208.153  0.60 24.37           C  
ATOM    137  CD BGLN A  40      26.367 -14.600 209.417  0.40 22.29           C  
ATOM    138  OE1AGLN A  40      26.910 -13.521 207.432  0.60 27.55           O  
ATOM    139  OE1BGLN A  40      25.893 -15.093 210.437  0.40 23.42           O  
ATOM    140  NE2AGLN A  40      26.297 -11.580 208.401  0.60 25.03           N  
ATOM    141  NE2BGLN A  40      27.665 -14.662 209.127  0.40 22.61           N  
ATOM    142  N   TYR A  41      23.822 -15.863 205.076  1.00 21.62           N  
ATOM    143  CA  TYR A  41      23.540 -17.053 204.328  1.00 22.18           C  
ATOM    144  C   TYR A  41      23.755 -18.245 205.230  1.00 23.14           C  
ATOM    145  O   TYR A  41      24.740 -18.305 205.992  1.00 23.78           O  
ATOM    146  CB  TYR A  41      24.467 -17.173 203.111  1.00 21.66           C  
ATOM    147  CG  TYR A  41      24.115 -18.298 202.174  1.00 21.84           C  
ATOM    148  CD1 TYR A  41      24.514 -19.611 202.441  1.00 21.73           C  
ATOM    149  CD2 TYR A  41      23.387 -18.062 201.021  1.00 20.50           C  
ATOM    150  CE1 TYR A  41      24.192 -20.641 201.585  1.00 21.91           C  
ATOM    151  CE2 TYR A  41      23.065 -19.080 200.163  1.00 21.39           C  
ATOM    152  CZ  TYR A  41      23.467 -20.372 200.456  1.00 21.47           C  
ATOM    153  OH  TYR A  41      23.146 -21.397 199.619  1.00 23.25           O  
ATOM    154  N   MET A  42      22.848 -19.198 205.134  1.00 22.20           N  
ATOM    155  CA  MET A  42      23.039 -20.516 205.731  1.00 23.65           C  
ATOM    156  C   MET A  42      22.352 -21.531 204.837  1.00 21.37           C  
ATOM    157  O   MET A  42      21.155 -21.408 204.553  1.00 20.91           O  
ATOM    158  CB  MET A  42      22.458 -20.608 207.152  1.00 26.43           C  
ATOM    159  CG  MET A  42      22.900 -21.863 207.921  1.00 29.91           C  
ATOM    160  SD  MET A  42      21.907 -22.289 209.380  1.00 37.38           S  
ATOM    161  CE  MET A  42      20.432 -22.918 208.585  1.00 36.85           C  
ATOM    162  N   SER A  43      23.099 -22.544 204.396  1.00 20.67           N  
ATOM    163  CA ASER A  43      22.497 -23.679 203.699  0.50 20.51           C  
ATOM    164  CA BSER A  43      22.512 -23.667 203.696  0.50 20.48           C  
ATOM    165  C   SER A  43      21.418 -24.257 204.583  1.00 20.25           C  
ATOM    166  O   SER A  43      21.663 -24.527 205.755  1.00 21.94           O  
ATOM    167  CB ASER A  43      23.525 -24.778 203.404  0.50 20.62           C  
ATOM    168  CB BSER A  43      23.589 -24.720 203.388  0.50 20.56           C  
ATOM    169  OG ASER A  43      24.543 -24.283 202.577  0.50 21.27           O  
ATOM    170  OG BSER A  43      22.999 -25.929 202.989  0.50 21.15           O  
ATOM    171  N   GLY A  44      20.223 -24.428 204.025  1.00 18.51           N  
ATOM    172  CA  GLY A  44      19.052 -24.897 204.772  1.00 17.95           C  
ATOM    173  C   GLY A  44      18.209 -23.815 205.444  1.00 16.64           C  
ATOM    174  O   GLY A  44      17.213 -24.131 206.066  1.00 18.08           O  
ATOM    175  N   GLY A  45      18.611 -22.546 205.323  1.00 15.87           N  
ATOM    176  CA  GLY A  45      17.931 -21.443 206.004  1.00 14.85           C  
ATOM    177  C   GLY A  45      16.687 -20.993 205.256  1.00 14.56           C  
ATOM    178  O   GLY A  45      16.744 -20.801 204.061  1.00 14.96           O  
ATOM    179  N   THR A  46      15.572 -20.821 205.975  1.00 13.78           N  
ATOM    180  CA  THR A  46      14.353 -20.228 205.410  1.00 14.52           C  
ATOM    181  C   THR A  46      13.868 -19.091 206.273  1.00 14.81           C  
ATOM    182  O   THR A  46      12.695 -18.750 206.234  1.00 15.03           O  
ATOM    183  CB  THR A  46      13.187 -21.241 205.226  1.00 14.45           C  
ATOM    184  OG1 THR A  46      12.615 -21.538 206.501  1.00 15.72           O  
ATOM    185  CG2 THR A  46      13.650 -22.525 204.560  1.00 14.44           C  
ATOM    186  N   GLY A  47      14.771 -18.480 207.036  1.00 15.36           N  
ATOM    187  CA  GLY A  47      14.429 -17.346 207.863  1.00 15.43           C  
ATOM    188  C   GLY A  47      13.998 -17.741 209.264  1.00 15.97           C  
ATOM    189  O   GLY A  47      13.855 -18.934 209.558  1.00 17.04           O  
ATOM    190  N   PRO A  48      13.763 -16.762 210.133  1.00 16.04           N  
ATOM    191  CA  PRO A  48      13.736 -15.346 209.744  1.00 15.61           C  
ATOM    192  C   PRO A  48      15.108 -14.683 209.664  1.00 15.56           C  
ATOM    193  O   PRO A  48      15.206 -13.574 209.166  1.00 15.32           O  
ATOM    194  CB  PRO A  48      12.896 -14.706 210.848  1.00 16.18           C  
ATOM    195  CG  PRO A  48      13.100 -15.602 212.024  1.00 16.85           C  
ATOM    196  CD  PRO A  48      13.115 -16.978 211.433  1.00 16.71           C  
ATOM    197  N   ASP A  49      16.157 -15.369 210.119  1.00 16.41           N  
ATOM    198  CA  ASP A  49      17.471 -14.750 210.280  1.00 18.12           C  
ATOM    199  C   ASP A  49      18.550 -15.306 209.371  1.00 16.26           C  
ATOM    200  O   ASP A  49      19.538 -14.614 209.126  1.00 17.34           O  
ATOM    201  CB  ASP A  49      17.901 -14.866 211.746  1.00 21.56           C  
ATOM    202  CG  ASP A  49      17.058 -13.991 212.663  1.00 23.92           C  
ATOM    203  OD1 ASP A  49      16.904 -12.785 212.380  1.00 28.72           O  
ATOM    204  OD2 ASP A  49      16.531 -14.517 213.647  1.00 28.12           O  
ATOM    205  N   LEU A  50      18.390 -16.541 208.908  1.00 15.79           N  
ATOM    206  CA  LEU A  50      19.401 -17.206 208.088  1.00 16.82           C  
ATOM    207  C   LEU A  50      18.739 -17.782 206.850  1.00 15.87           C  
ATOM    208  O   LEU A  50      17.655 -18.382 206.940  1.00 15.78           O  
ATOM    209  CB  LEU A  50      20.065 -18.314 208.883  1.00 17.71           C  
ATOM    210  CG  LEU A  50      20.787 -17.836 210.150  1.00 19.27           C  
ATOM    211  CD1 LEU A  50      21.093 -19.005 211.061  1.00 20.24           C  
ATOM    212  CD2 LEU A  50      22.049 -17.082 209.783  1.00 19.57           C  
ATOM    213  N   PHE A  51      19.388 -17.622 205.694  1.00 15.60           N  
ATOM    214  CA  PHE A  51      18.759 -17.959 204.408  1.00 14.83           C  
ATOM    215  C   PHE A  51      19.678 -18.670 203.443  1.00 15.80           C  
ATOM    216  O   PHE A  51      20.842 -18.298 203.328  1.00 16.02           O  
ATOM    217  CB  PHE A  51      18.281 -16.689 203.705  1.00 14.73           C  
ATOM    218  CG  PHE A  51      17.168 -16.024 204.409  1.00 14.11           C  
ATOM    219  CD1 PHE A  51      15.868 -16.479 204.241  1.00 14.40           C  
ATOM    220  CD2 PHE A  51      17.412 -14.999 205.315  1.00 14.10           C  
ATOM    221  CE1 PHE A  51      14.823 -15.880 204.926  1.00 13.90           C  
ATOM    222  CE2 PHE A  51      16.372 -14.401 206.003  1.00 13.87           C  
ATOM    223  CZ  PHE A  51      15.068 -14.858 205.811  1.00 13.71           C  
ATOM    224  N   ASP A  52      19.135 -19.649 202.725  1.00 15.39           N  
ATOM    225  CA  ASP A  52      19.687 -20.017 201.411  1.00 16.04           C  
ATOM    226  C   ASP A  52      18.834 -19.386 200.310  1.00 16.01           C  
ATOM    227  O   ASP A  52      17.841 -18.717 200.620  1.00 13.87           O  
ATOM    228  CB  ASP A  52      19.944 -21.521 201.260  1.00 16.40           C  
ATOM    229  CG  ASP A  52      18.714 -22.372 201.347  1.00 17.79           C  
ATOM    230  OD1 ASP A  52      17.592 -21.938 200.999  1.00 16.48           O  
ATOM    231  OD2 ASP A  52      18.883 -23.542 201.770  1.00 17.49           O  
ATOM    232  N   CYS A  53      19.225 -19.543 199.047  1.00 15.89           N  
ATOM    233  CA  CYS A  53      18.559 -18.792 197.973  1.00 16.64           C  
ATOM    234  C   CYS A  53      17.052 -19.084 197.887  1.00 14.73           C  
ATOM    235  O   CYS A  53      16.221 -18.171 197.864  1.00 13.95           O  
ATOM    236  CB  CYS A  53      19.244 -18.995 196.606  1.00 18.19           C  
ATOM    237  SG  CYS A  53      19.044 -20.633 195.875  1.00 24.17           S  
ATOM    238  N   SER A  54      16.713 -20.361 197.869  1.00 13.81           N  
ATOM    239  CA  SER A  54      15.315 -20.801 197.820  1.00 13.24           C  
ATOM    240  C   SER A  54      14.573 -20.596 199.149  1.00 12.41           C  
ATOM    241  O   SER A  54      13.355 -20.398 199.148  1.00 12.42           O  
ATOM    242  CB  SER A  54      15.234 -22.262 197.380  1.00 13.62           C  
ATOM    243  OG  SER A  54      16.064 -23.038 198.219  1.00 15.69           O  
ATOM    244  N   GLY A  55      15.297 -20.616 200.263  1.00 12.21           N  
ATOM    245  CA  GLY A  55      14.692 -20.312 201.562  1.00 12.72           C  
ATOM    246  C   GLY A  55      14.213 -18.879 201.647  1.00 12.57           C  
ATOM    247  O   GLY A  55      13.177 -18.615 202.228  1.00 12.84           O  
ATOM    248  N   LEU A  56      14.986 -17.946 201.107  1.00 12.39           N  
ATOM    249  CA  LEU A  56      14.517 -16.549 201.014  1.00 12.69           C  
ATOM    250  C   LEU A  56      13.223 -16.435 200.201  1.00 11.95           C  
ATOM    251  O   LEU A  56      12.288 -15.735 200.602  1.00 12.03           O  
ATOM    252  CB  LEU A  56      15.582 -15.622 200.423  1.00 12.99           C  
ATOM    253  CG  LEU A  56      15.155 -14.153 200.307  1.00 12.96           C  
ATOM    254  CD1 LEU A  56      14.941 -13.484 201.664  1.00 13.69           C  
ATOM    255  CD2 LEU A  56      16.213 -13.399 199.512  1.00 14.30           C  
ATOM    256  N   VAL A  57      13.172 -17.122 199.059  1.00 12.41           N  
ATOM    257  CA  VAL A  57      11.988 -17.118 198.220  1.00 12.36           C  
ATOM    258  C   VAL A  57      10.792 -17.661 199.008  1.00 12.31           C  
ATOM    259  O   VAL A  57       9.706 -17.059 199.001  1.00 12.04           O  
ATOM    260  CB  VAL A  57      12.239 -17.912 196.912  1.00 12.39           C  
ATOM    261  CG1 VAL A  57      10.955 -18.173 196.136  1.00 12.66           C  
ATOM    262  CG2 VAL A  57      13.255 -17.174 196.040  1.00 12.52           C  
ATOM    263  N   LEU A  58      10.986 -18.801 199.664  1.00 11.77           N  
ATOM    264  CA  LEU A  58       9.907 -19.471 200.387  1.00 11.94           C  
ATOM    265  C   LEU A  58       9.383 -18.608 201.530  1.00 11.88           C  
ATOM    266  O   LEU A  58       8.177 -18.402 201.661  1.00 12.12           O  
ATOM    267  CB  LEU A  58      10.383 -20.823 200.927  1.00 12.09           C  
ATOM    268  CG  LEU A  58       9.391 -21.635 201.763  1.00 12.84           C  
ATOM    269  CD1 LEU A  58       8.116 -21.905 200.989  1.00 13.37           C  
ATOM    270  CD2 LEU A  58      10.061 -22.915 202.215  1.00 13.17           C  
ATOM    271  N   TYR A  59      10.297 -18.089 202.330  1.00 11.85           N  
ATOM    272  CA  TYR A  59       9.943 -17.171 203.424  1.00 12.06           C  
ATOM    273  C   TYR A  59       9.131 -15.992 202.913  1.00 11.89           C  
ATOM    274  O   TYR A  59       8.106 -15.628 203.506  1.00 12.88           O  
ATOM    275  CB  TYR A  59      11.222 -16.644 204.054  1.00 11.80           C  
ATOM    276  CG  TYR A  59      11.066 -15.630 205.151  1.00 12.22           C  
ATOM    277  CD1 TYR A  59      10.799 -16.009 206.459  1.00 12.25           C  
ATOM    278  CD2 TYR A  59      11.218 -14.263 204.887  1.00 12.51           C  
ATOM    279  CE1 TYR A  59      10.691 -15.053 207.475  1.00 12.90           C  
ATOM    280  CE2 TYR A  59      11.109 -13.306 205.889  1.00 12.72           C  
ATOM    281  CZ  TYR A  59      10.836 -13.693 207.177  1.00 13.32           C  
ATOM    282  OH  TYR A  59      10.732 -12.721 208.181  1.00 14.60           O  
ATOM    283  N   SER A  60       9.593 -15.370 201.834  1.00 12.17           N  
ATOM    284  CA  SER A  60       8.973 -14.120 201.352  1.00 12.03           C  
ATOM    285  C   SER A  60       7.525 -14.344 200.942  1.00 12.56           C  
ATOM    286  O   SER A  60       6.665 -13.499 201.170  1.00 13.19           O  
ATOM    287  CB  SER A  60       9.780 -13.517 200.195  1.00 12.14           C  
ATOM    288  OG  SER A  60      11.083 -13.175 200.644  1.00 12.17           O  
ATOM    289  N   HIS A  61       7.255 -15.490 200.324  1.00 11.78           N  
ATOM    290  CA  HIS A  61       5.887 -15.854 199.983  1.00 11.51           C  
ATOM    291  C   HIS A  61       5.049 -16.240 201.203  1.00 11.58           C  
ATOM    292  O   HIS A  61       3.922 -15.751 201.364  1.00 12.01           O  
ATOM    293  CB  HIS A  61       5.913 -16.983 198.973  1.00 11.33           C  
ATOM    294  CG  HIS A  61       6.330 -16.559 197.600  1.00 11.37           C  
ATOM    295  ND1 HIS A  61       7.651 -16.386 197.235  1.00 11.71           N  
ATOM    296  CD2 HIS A  61       5.594 -16.297 196.492  1.00 11.50           C  
ATOM    297  CE1 HIS A  61       7.702 -16.041 195.961  1.00 11.54           C  
ATOM    298  NE2 HIS A  61       6.470 -15.979 195.493  1.00 11.47           N  
ATOM    299  N   ASN A  62       5.565 -17.158 202.023  1.00 11.66           N  
ATOM    300  CA  ASN A  62       4.848 -17.595 203.225  1.00 12.33           C  
ATOM    301  C   ASN A  62       4.438 -16.414 204.105  1.00 12.91           C  
ATOM    302  O   ASN A  62       3.318 -16.378 204.609  1.00 12.72           O  
ATOM    303  CB  ASN A  62       5.681 -18.550 204.072  1.00 12.24           C  
ATOM    304  CG  ASN A  62       5.637 -19.991 203.579  1.00 12.15           C  
ATOM    305  OD1 ASN A  62       4.854 -20.362 202.700  1.00 12.90           O  
ATOM    306  ND2 ASN A  62       6.505 -20.813 204.154  1.00 12.38           N  
ATOM    307  N   GLN A  63       5.346 -15.455 204.294  1.00 12.98           N  
ATOM    308  CA  GLN A  63       5.063 -14.307 205.178  1.00 13.87           C  
ATOM    309  C   GLN A  63       3.905 -13.457 204.668  1.00 13.57           C  
ATOM    310  O   GLN A  63       3.236 -12.804 205.461  1.00 14.08           O  
ATOM    311  CB  GLN A  63       6.301 -13.432 205.323  1.00 14.11           C  
ATOM    312  CG  GLN A  63       7.391 -14.065 206.128  1.00 15.42           C  
ATOM    313  CD  GLN A  63       7.083 -14.123 207.594  1.00 17.46           C  
ATOM    314  OE1 GLN A  63       6.930 -15.211 208.168  1.00 20.91           O  
ATOM    315  NE2 GLN A  63       6.967 -12.962 208.211  1.00 18.52           N  
ATOM    316  N   CYS A  64       3.679 -13.495 203.364  1.00 13.46           N  
ATOM    317  CA  CYS A  64       2.559 -12.776 202.707  1.00 14.16           C  
ATOM    318  C   CYS A  64       1.298 -13.623 202.477  1.00 14.56           C  
ATOM    319  O   CYS A  64       0.368 -13.169 201.801  1.00 15.44           O  
ATOM    320  CB  CYS A  64       3.052 -12.215 201.373  1.00 13.85           C  
ATOM    321  SG  CYS A  64       4.334 -10.968 201.555  1.00 14.67           S  
ATOM    322  N   GLY A  65       1.266 -14.849 202.994  1.00 14.67           N  
ATOM    323  CA  GLY A  65       0.132 -15.760 202.789  1.00 14.57           C  
ATOM    324  C   GLY A  65       0.009 -16.297 201.385  1.00 14.87           C  
ATOM    325  O   GLY A  65      -1.089 -16.690 200.954  1.00 15.15           O  
ATOM    326  N   VAL A  66       1.115 -16.301 200.644  1.00 13.38           N  
ATOM    327  CA  VAL A  66       1.119 -16.823 199.302  1.00 13.20           C  
ATOM    328  C   VAL A  66       1.652 -18.247 199.386  1.00 13.55           C  
ATOM    329  O   VAL A  66       2.864 -18.490 199.324  1.00 13.34           O  
ATOM    330  CB  VAL A  66       1.900 -15.947 198.316  1.00 13.40           C  
ATOM    331  CG1 VAL A  66       1.820 -16.527 196.922  1.00 13.79           C  
ATOM    332  CG2 VAL A  66       1.356 -14.520 198.320  1.00 13.93           C  
ATOM    333  N   TYR A  67       0.722 -19.178 199.566  1.00 13.82           N  
ATOM    334  CA  TYR A  67       1.103 -20.568 199.798  1.00 14.25           C  
ATOM    335  C   TYR A  67       1.327 -21.288 198.471  1.00 14.10           C  
ATOM    336  O   TYR A  67       0.993 -20.761 197.386  1.00 14.00           O  
ATOM    337  CB  TYR A  67       0.084 -21.255 200.704  1.00 14.55           C  
ATOM    338  CG  TYR A  67      -0.106 -20.523 202.024  1.00 15.36           C  
ATOM    339  CD1 TYR A  67       0.985 -20.167 202.799  1.00 15.64           C  
ATOM    340  CD2 TYR A  67      -1.372 -20.133 202.466  1.00 16.17           C  
ATOM    341  CE1 TYR A  67       0.838 -19.476 203.990  1.00 16.64           C  
ATOM    342  CE2 TYR A  67      -1.528 -19.419 203.659  1.00 16.93           C  
ATOM    343  CZ  TYR A  67      -0.414 -19.104 204.410  1.00 17.97           C  
ATOM    344  OH  TYR A  67      -0.527 -18.438 205.593  1.00 19.91           O  
ATOM    345  N   GLY A  68       1.914 -22.486 198.559  1.00 14.27           N  
ATOM    346  CA  GLY A  68       2.132 -23.335 197.395  1.00 14.02           C  
ATOM    347  C   GLY A  68       3.521 -23.341 196.815  1.00 14.51           C  
ATOM    348  O   GLY A  68       3.766 -24.046 195.834  1.00 15.65           O  
ATOM    349  N   VAL A  69       4.450 -22.595 197.414  1.00 14.10           N  
ATOM    350  CA  VAL A  69       5.803 -22.477 196.895  1.00 14.15           C  
ATOM    351  C   VAL A  69       6.616 -23.662 197.384  1.00 14.85           C  
ATOM    352  O   VAL A  69       6.602 -23.956 198.571  1.00 14.15           O  
ATOM    353  CB  VAL A  69       6.475 -21.146 197.328  1.00 14.13           C  
ATOM    354  CG1 VAL A  69       7.894 -21.019 196.790  1.00 13.63           C  
ATOM    355  CG2 VAL A  69       5.613 -19.972 196.868  1.00 14.65           C  
ATOM    356  N   PRO A  70       7.329 -24.361 196.465  1.00 15.14           N  
ATOM    357  CA  PRO A  70       8.169 -25.484 196.922  1.00 15.91           C  
ATOM    358  C   PRO A  70       9.447 -25.017 197.604  1.00 15.32           C  
ATOM    359  O   PRO A  70       9.703 -23.807 197.696  1.00 14.62           O  
ATOM    360  CB  PRO A  70       8.457 -26.280 195.634  1.00 15.98           C  
ATOM    361  CG  PRO A  70       8.213 -25.346 194.524  1.00 16.42           C  
ATOM    362  CD  PRO A  70       7.342 -24.213 194.995  1.00 15.67           C  
ATOM    363  N   ARG A  71      10.214 -25.961 198.145  1.00 15.23           N  
ATOM    364  CA  ARG A  71      11.355 -25.633 199.010  1.00 15.75           C  
ATOM    365  C   ARG A  71      12.664 -25.304 198.274  1.00 16.73           C  
ATOM    366  O   ARG A  71      13.384 -24.384 198.688  1.00 14.85           O  
ATOM    367  CB  ARG A  71      11.616 -26.791 200.022  1.00 15.59           C  
ATOM    368  CG  ARG A  71      12.869 -26.639 200.874  1.00 15.18           C  
ATOM    369  CD  ARG A  71      12.867 -25.407 201.773  1.00 15.24           C  
ATOM    370  NE  ARG A  71      14.135 -25.227 202.468  1.00 15.29           N  
ATOM    371  CZ  ARG A  71      15.152 -24.469 202.060  1.00 15.62           C  
ATOM    372  NH1 ARG A  71      15.100 -23.785 200.924  1.00 15.52           N  
ATOM    373  NH2 ARG A  71      16.239 -24.391 202.809  1.00 17.02           N  
ATOM    374  N   VAL A  72      13.012 -26.092 197.254  1.00 17.95           N  
ATOM    375  CA  VAL A  72      14.333 -25.950 196.597  1.00 19.58           C  
ATOM    376  C   VAL A  72      14.228 -25.278 195.248  1.00 18.52           C  
ATOM    377  O   VAL A  72      13.174 -25.315 194.597  1.00 16.60           O  
ATOM    378  CB  VAL A  72      15.143 -27.275 196.477  1.00 22.10           C  
ATOM    379  CG1 VAL A  72      15.496 -27.794 197.866  1.00 24.17           C  
ATOM    380  CG2 VAL A  72      14.419 -28.332 195.645  1.00 22.59           C  
ATOM    381  N   ALA A  73      15.356 -24.694 194.850  1.00 18.51           N  
ATOM    382  CA  ALA A  73      15.456 -23.855 193.663  1.00 17.86           C  
ATOM    383  C   ALA A  73      14.974 -24.583 192.435  1.00 17.94           C  
ATOM    384  O   ALA A  73      14.211 -24.031 191.618  1.00 16.94           O  
ATOM    385  CB  ALA A  73      16.885 -23.386 193.472  1.00 17.94           C  
ATOM    386  N   LYS A  74      15.387 -25.840 192.286  1.00 17.78           N  
ATOM    387  CA  LYS A  74      15.019 -26.564 191.062  1.00 19.50           C  
ATOM    388  C   LYS A  74      13.504 -26.725 190.924  1.00 18.78           C  
ATOM    389  O   LYS A  74      12.982 -26.660 189.823  1.00 18.41           O  
ATOM    390  CB  LYS A  74      15.784 -27.902 190.922  1.00 21.02           C  
ATOM    391  CG  LYS A  74      15.469 -28.981 191.936  1.00 23.96           C  
ATOM    392  CD  LYS A  74      16.479 -30.128 191.823  1.00 24.75           C  
ATOM    393  N   ASP A  75      12.794 -26.888 192.045  1.00 17.40           N  
ATOM    394  CA  ASP A  75      11.345 -27.007 192.019  1.00 17.19           C  
ATOM    395  C   ASP A  75      10.650 -25.643 191.923  1.00 16.16           C  
ATOM    396  O   ASP A  75       9.614 -25.509 191.259  1.00 16.04           O  
ATOM    397  CB  ASP A  75      10.856 -27.754 193.244  1.00 18.39           C  
ATOM    398  CG  ASP A  75      11.352 -29.183 193.305  1.00 20.22           C  
ATOM    399  OD1 ASP A  75      11.613 -29.790 192.248  1.00 20.49           O  
ATOM    400  OD2 ASP A  75      11.498 -29.696 194.423  1.00 19.69           O  
ATOM    401  N   GLN A  76      11.220 -24.628 192.566  1.00 16.50           N  
ATOM    402  CA  GLN A  76      10.626 -23.277 192.495  1.00 15.71           C  
ATOM    403  C   GLN A  76      10.622 -22.740 191.050  1.00 16.45           C  
ATOM    404  O   GLN A  76       9.734 -21.984 190.663  1.00 17.28           O  
ATOM    405  CB  GLN A  76      11.364 -22.319 193.415  1.00 15.05           C  
ATOM    406  CG  GLN A  76      11.194 -22.631 194.907  1.00 14.72           C  
ATOM    407  CD  GLN A  76      11.990 -21.717 195.816  1.00 14.88           C  
ATOM    408  OE1 GLN A  76      12.868 -20.970 195.365  1.00 15.07           O  
ATOM    409  NE2 GLN A  76      11.683 -21.764 197.113  1.00 13.33           N  
ATOM    410  N   ALA A  77      11.630 -23.142 190.275  1.00 16.91           N  
ATOM    411  CA  ALA A  77      11.742 -22.786 188.852  1.00 18.33           C  
ATOM    412  C   ALA A  77      10.659 -23.415 187.975  1.00 18.87           C  
ATOM    413  O   ALA A  77      10.354 -22.907 186.896  1.00 19.62           O  
ATOM    414  CB  ALA A  77      13.118 -23.168 188.330  1.00 18.98           C  
ATOM    415  N   ARG A  78      10.080 -24.514 188.440  1.00 19.28           N  
ATOM    416  CA  ARG A  78       9.082 -25.250 187.681  1.00 21.04           C  
ATOM    417  C   ARG A  78       7.649 -25.002 188.117  1.00 21.14           C  
ATOM    418  O   ARG A  78       6.735 -25.276 187.356  1.00 21.32           O  
ATOM    419  CB  ARG A  78       9.395 -26.743 187.759  1.00 21.27           C  
ATOM    420  CG  ARG A  78      10.689 -27.126 187.078  1.00 23.45           C  
ATOM    421  CD  ARG A  78      10.836 -28.647 187.029  1.00 24.38           C  
ATOM    422  N   GLY A  79       7.444 -24.521 189.341  1.00 19.80           N  
ATOM    423  CA  GLY A  79       6.106 -24.313 189.878  1.00 20.55           C  
ATOM    424  C   GLY A  79       5.537 -22.963 189.495  1.00 19.65           C  
ATOM    425  O   GLY A  79       6.165 -22.176 188.767  1.00 19.91           O  
ATOM    426  N   GLY A  80       4.338 -22.698 190.008  1.00 20.46           N  
ATOM    427  CA  GLY A  80       3.598 -21.488 189.710  1.00 21.09           C  
ATOM    428  C   GLY A  80       3.284 -21.333 188.241  1.00 22.03           C  
ATOM    429  O   GLY A  80       3.180 -22.318 187.507  1.00 22.87           O  
ATOM    430  N   LYS A  81       3.134 -20.093 187.807  1.00 22.35           N  
ATOM    431  CA  LYS A  81       2.897 -19.802 186.394  1.00 23.93           C  
ATOM    432  C   LYS A  81       4.070 -18.971 185.871  1.00 22.94           C  
ATOM    433  O   LYS A  81       4.952 -18.557 186.644  1.00 20.36           O  
ATOM    434  CB  LYS A  81       1.559 -19.098 186.197  1.00 27.20           C  
ATOM    435  CG  LYS A  81       1.451 -17.713 186.807  1.00 29.45           C  
ATOM    436  CD  LYS A  81       0.071 -17.098 186.589  1.00 31.76           C  
ATOM    437  CE  LYS A  81      -0.257 -16.077 187.669  1.00 31.66           C  
ATOM    438  NZ  LYS A  81      -1.354 -15.155 187.269  0.50 33.09           N  
ATOM    439  N   ALA A  82       4.110 -18.773 184.553  1.00 22.39           N  
ATOM    440  CA  ALA A  82       5.138 -17.922 183.933  1.00 21.44           C  
ATOM    441  C   ALA A  82       5.051 -16.512 184.480  1.00 21.18           C  
ATOM    442  O   ALA A  82       3.950 -15.944 184.615  1.00 20.98           O  
ATOM    443  CB  ALA A  82       4.983 -17.885 182.408  1.00 22.62           C  
ATOM    444  N   GLY A  83       6.219 -15.961 184.791  1.00 20.53           N  
ATOM    445  CA  GLY A  83       6.352 -14.606 185.290  1.00 20.23           C  
ATOM    446  C   GLY A  83       6.880 -13.705 184.210  1.00 20.24           C  
ATOM    447  O   GLY A  83       7.224 -14.159 183.116  1.00 18.86           O  
ATOM    448  N   SER A  84       6.931 -12.416 184.520  1.00 20.91           N  
ATOM    449  CA  SER A  84       7.448 -11.382 183.618  1.00 21.97           C  
ATOM    450  C   SER A  84       8.656 -10.642 184.144  1.00 21.02           C  
ATOM    451  O   SER A  84       9.243  -9.838 183.433  1.00 21.63           O  
ATOM    452  CB  SER A  84       6.342 -10.365 183.392  1.00 21.86           C  
ATOM    453  OG  SER A  84       6.038  -9.721 184.618  1.00 21.44           O  
ATOM    454  N   GLY A  85       9.032 -10.888 185.401  1.00 20.76           N  
ATOM    455  CA  GLY A  85      10.109 -10.170 186.046  1.00 19.81           C  
ATOM    456  C   GLY A  85       9.646  -8.944 186.813  1.00 18.48           C  
ATOM    457  O   GLY A  85      10.466  -8.145 187.241  1.00 19.75           O  
ATOM    458  N   ALA A  86       8.334  -8.833 187.016  1.00 17.30           N  
ATOM    459  CA  ALA A  86       7.736  -7.816 187.876  1.00 18.15           C  
ATOM    460  C   ALA A  86       8.104  -8.051 189.337  1.00 17.37           C  
ATOM    461  O   ALA A  86       8.527  -9.145 189.736  1.00 16.43           O  
ATOM    462  CB  ALA A  86       6.225  -7.816 187.736  1.00 18.59           C  
ATOM    463  N   ALA A  87       7.955  -6.999 190.136  1.00 16.72           N  
ATOM    464  CA  ALA A  87       8.212  -7.099 191.564  1.00 15.73           C  
ATOM    465  C   ALA A  87       7.513  -8.339 192.149  1.00 15.22           C  
ATOM    466  O   ALA A  87       6.302  -8.523 191.971  1.00 15.49           O  
ATOM    467  CB  ALA A  87       7.732  -5.840 192.282  1.00 16.04           C  
ATOM    468  N   GLY A  88       8.278  -9.166 192.844  1.00 14.06           N  
ATOM    469  CA  GLY A  88       7.750 -10.331 193.532  1.00 13.86           C  
ATOM    470  C   GLY A  88       7.767 -11.601 192.715  1.00 13.46           C  
ATOM    471  O   GLY A  88       7.510 -12.664 193.262  1.00 13.59           O  
ATOM    472  N   ASP A  89       8.070 -11.521 191.414  1.00 12.64           N  
ATOM    473  CA  ASP A  89       8.270 -12.736 190.630  1.00 13.23           C  
ATOM    474  C   ASP A  89       9.528 -13.433 191.116  1.00 12.89           C  
ATOM    475  O   ASP A  89      10.405 -12.814 191.706  1.00 13.40           O  
ATOM    476  CB  ASP A  89       8.410 -12.423 189.131  1.00 14.71           C  
ATOM    477  CG  ASP A  89       7.085 -12.088 188.471  1.00 15.63           C  
ATOM    478  OD1 ASP A  89       6.029 -12.138 189.123  1.00 16.95           O  
ATOM    479  OD2 ASP A  89       7.103 -11.776 187.265  1.00 18.19           O  
ATOM    480  N   VAL A  90       9.580 -14.735 190.928  1.00 12.71           N  
ATOM    481  CA  VAL A  90      10.771 -15.498 191.226  1.00 12.78           C  
ATOM    482  C   VAL A  90      11.641 -15.542 189.968  1.00 13.68           C  
ATOM    483  O   VAL A  90      11.201 -15.997 188.936  1.00 14.29           O  
ATOM    484  CB  VAL A  90      10.435 -16.950 191.664  1.00 12.92           C  
ATOM    485  CG1 VAL A  90      11.704 -17.731 191.912  1.00 13.28           C  
ATOM    486  CG2 VAL A  90       9.531 -16.936 192.894  1.00 13.30           C  
ATOM    487  N   VAL A  91      12.890 -15.124 190.086  1.00 13.43           N  
ATOM    488  CA  VAL A  91      13.846 -15.323 188.998  1.00 13.94           C  
ATOM    489  C   VAL A  91      14.630 -16.594 189.323  1.00 13.75           C  
ATOM    490  O   VAL A  91      15.061 -16.768 190.450  1.00 13.89           O  
ATOM    491  CB  VAL A  91      14.752 -14.092 188.751  1.00 13.68           C  
ATOM    492  CG1 VAL A  91      15.495 -13.612 190.006  1.00 14.60           C  
ATOM    493  CG2 VAL A  91      15.712 -14.369 187.589  1.00 13.94           C  
ATOM    494  N   TYR A  92      14.806 -17.473 188.336  1.00 15.18           N  
ATOM    495  CA  TYR A  92      15.597 -18.693 188.517  1.00 15.73           C  
ATOM    496  C   TYR A  92      16.733 -18.731 187.501  1.00 16.56           C  
ATOM    497  O   TYR A  92      16.635 -18.085 186.451  1.00 16.13           O  
ATOM    498  CB  TYR A  92      14.739 -19.944 188.407  1.00 16.60           C  
ATOM    499  CG  TYR A  92      14.034 -20.090 187.081  1.00 17.64           C  
ATOM    500  CD1 TYR A  92      14.685 -20.681 185.996  1.00 18.91           C  
ATOM    501  CD2 TYR A  92      12.738 -19.604 186.907  1.00 18.47           C  
ATOM    502  CE1 TYR A  92      14.058 -20.798 184.781  1.00 19.37           C  
ATOM    503  CE2 TYR A  92      12.077 -19.738 185.693  1.00 19.25           C  
ATOM    504  CZ  TYR A  92      12.756 -20.337 184.635  1.00 19.68           C  
ATOM    505  OH  TYR A  92      12.158 -20.474 183.431  1.00 21.47           O  
ATOM    506  N   PHE A  93      17.786 -19.481 187.831  1.00 17.03           N  
ATOM    507  CA  PHE A  93      19.001 -19.536 187.011  1.00 18.41           C  
ATOM    508  C   PHE A  93      19.306 -20.979 186.672  1.00 19.45           C  
ATOM    509  O   PHE A  93      19.538 -21.788 187.565  1.00 18.56           O  
ATOM    510  CB  PHE A  93      20.162 -18.845 187.712  1.00 18.19           C  
ATOM    511  CG  PHE A  93      19.897 -17.393 187.985  1.00 18.43           C  
ATOM    512  CD1 PHE A  93      19.293 -16.987 189.183  1.00 17.76           C  
ATOM    513  CD2 PHE A  93      20.197 -16.429 187.031  1.00 18.18           C  
ATOM    514  CE1 PHE A  93      19.004 -15.646 189.406  1.00 17.31           C  
ATOM    515  CE2 PHE A  93      19.923 -15.082 187.263  1.00 18.31           C  
ATOM    516  CZ  PHE A  93      19.324 -14.694 188.468  1.00 17.42           C  
ATOM    517  N   GLY A  94      19.260 -21.300 185.379  1.00 22.56           N  
ATOM    518  CA  GLY A  94      19.489 -22.678 184.905  1.00 26.15           C  
ATOM    519  C   GLY A  94      18.244 -23.537 184.783  1.00 28.94           C  
ATOM    520  O   GLY A  94      17.181 -23.211 185.311  1.00 29.97           O  
ATOM    521  N   ASN A  95      18.388 -24.664 184.073  1.00 34.12           N  
ATOM    522  CA  ASN A  95      17.307 -25.649 183.887  1.00 34.25           C  
ATOM    523  C   ASN A  95      18.000 -27.012 183.768  1.00 35.46           C  
ATOM    524  O   ASN A  95      18.450 -27.352 182.668  1.00 37.39           O  
ATOM    525  CB  ASN A  95      16.456 -25.302 182.646  1.00 36.24           C  
ATOM    526  CG  ASN A  95      15.362 -26.338 182.345  1.00 37.43           C  
ATOM    527  OD1 ASN A  95      15.195 -27.305 183.076  1.00 37.06           O  
ATOM    528  ND2 ASN A  95      14.599 -26.118 181.270  1.00 37.48           N  
ATOM    529  N   PRO A  96      18.130 -27.784 184.858  1.00 33.60           N  
ATOM    530  CA  PRO A  96      17.533 -27.529 186.193  1.00 31.97           C  
ATOM    531  C   PRO A  96      18.125 -26.337 186.982  1.00 29.58           C  
ATOM    532  O   PRO A  96      19.342 -26.146 187.019  1.00 28.59           O  
ATOM    533  CB  PRO A  96      17.818 -28.837 186.945  1.00 33.42           C  
ATOM    534  CG  PRO A  96      19.095 -29.350 186.333  1.00 34.37           C  
ATOM    535  CD  PRO A  96      19.105 -28.893 184.897  1.00 35.60           C  
ATOM    536  N   ALA A  97      17.259 -25.566 187.636  1.00 25.59           N  
ATOM    537  CA  ALA A  97      17.693 -24.340 188.287  1.00 23.61           C  
ATOM    538  C   ALA A  97      18.521 -24.636 189.511  1.00 22.92           C  
ATOM    539  O   ALA A  97      18.183 -25.544 190.292  1.00 22.25           O  
ATOM    540  CB  ALA A  97      16.495 -23.479 188.663  1.00 22.89           C  
ATOM    541  N   HIS A  98      19.605 -23.892 189.674  1.00 20.05           N  
ATOM    542  CA  HIS A  98      20.468 -24.031 190.850  1.00 21.98           C  
ATOM    543  C   HIS A  98      20.462 -22.784 191.755  1.00 19.93           C  
ATOM    544  O   HIS A  98      21.083 -22.790 192.812  1.00 21.33           O  
ATOM    545  CB  HIS A  98      21.896 -24.367 190.419  1.00 23.79           C  
ATOM    546  CG  HIS A  98      22.598 -23.223 189.761  1.00 26.77           C  
ATOM    547  ND1 HIS A  98      23.403 -22.350 190.459  1.00 29.50           N  
ATOM    548  CD2 HIS A  98      22.560 -22.769 188.487  1.00 29.03           C  
ATOM    549  CE1 HIS A  98      23.845 -21.413 189.638  1.00 29.96           C  
ATOM    550  NE2 HIS A  98      23.342 -21.642 188.438  1.00 29.26           N  
ATOM    551  N   HIS A  99      19.793 -21.710 191.338  1.00 18.60           N  
ATOM    552  CA  HIS A  99      19.768 -20.480 192.121  1.00 17.17           C  
ATOM    553  C   HIS A  99      18.477 -19.726 191.822  1.00 16.14           C  
ATOM    554  O   HIS A  99      17.926 -19.829 190.714  1.00 14.87           O  
ATOM    555  CB  HIS A  99      20.985 -19.617 191.798  1.00 18.08           C  
ATOM    556  CG  HIS A  99      21.184 -18.482 192.743  1.00 18.61           C  
ATOM    557  ND1 HIS A  99      21.635 -18.659 194.030  1.00 19.48           N  
ATOM    558  CD2 HIS A  99      20.960 -17.155 192.597  1.00 18.45           C  
ATOM    559  CE1 HIS A  99      21.705 -17.484 194.630  1.00 20.03           C  
ATOM    560  NE2 HIS A  99      21.297 -16.557 193.786  1.00 18.19           N  
ATOM    561  N   VAL A 100      17.989 -18.984 192.819  1.00 15.15           N  
ATOM    562  CA  VAL A 100      16.778 -18.174 192.651  1.00 14.70           C  
ATOM    563  C   VAL A 100      16.902 -16.884 193.441  1.00 14.00           C  
ATOM    564  O   VAL A 100      17.755 -16.771 194.342  1.00 14.33           O  
ATOM    565  CB  VAL A 100      15.490 -18.910 193.147  1.00 14.52           C  
ATOM    566  CG1 VAL A 100      15.128 -20.076 192.234  1.00 15.61           C  
ATOM    567  CG2 VAL A 100      15.645 -19.380 194.580  1.00 14.34           C  
ATOM    568  N   GLY A 101      16.062 -15.923 193.077  1.00 13.30           N  
ATOM    569  CA  GLY A 101      15.919 -14.681 193.817  1.00 13.58           C  
ATOM    570  C   GLY A 101      14.519 -14.104 193.594  1.00 13.55           C  
ATOM    571  O   GLY A 101      13.709 -14.669 192.850  1.00 12.88           O  
ATOM    572  N   ILE A 102      14.244 -12.990 194.266  1.00 13.24           N  
ATOM    573  CA  ILE A 102      12.990 -12.278 194.155  1.00 13.30           C  
ATOM    574  C   ILE A 102      13.233 -11.016 193.343  1.00 13.54           C  
ATOM    575  O   ILE A 102      14.083 -10.189 193.688  1.00 13.19           O  
ATOM    576  CB  ILE A 102      12.413 -11.893 195.537  1.00 13.25           C  
ATOM    577  CG1 ILE A 102      12.082 -13.152 196.356  1.00 13.14           C  
ATOM    578  CG2 ILE A 102      11.202 -10.978 195.365  1.00 13.26           C  
ATOM    579  CD1 ILE A 102      10.973 -14.019 195.784  1.00 13.63           C  
ATOM    580  N   CYS A 103      12.468 -10.884 192.261  1.00 13.96           N  
ATOM    581  CA  CYS A 103      12.624  -9.742 191.360  1.00 14.55           C  
ATOM    582  C   CYS A 103      12.188  -8.461 192.015  1.00 15.00           C  
ATOM    583  O   CYS A 103      11.128  -8.407 192.631  1.00 14.20           O  
ATOM    584  CB  CYS A 103      11.772  -9.920 190.113  1.00 14.82           C  
ATOM    585  SG  CYS A 103      12.266 -11.327 189.092  1.00 16.92           S  
ATOM    586  N   CYS A 104      12.999  -7.427 191.834  1.00 15.84           N  
ATOM    587  CA  CYS A 104      12.626  -6.070 192.239  1.00 16.49           C  
ATOM    588  C   CYS A 104      11.735  -5.369 191.213  1.00 17.30           C  
ATOM    589  O   CYS A 104      11.080  -4.378 191.543  1.00 17.97           O  
ATOM    590  CB  CYS A 104      13.868  -5.244 192.499  1.00 17.18           C  
ATOM    591  SG  CYS A 104      14.973  -5.935 193.743  1.00 16.84           S  
ATOM    592  N   GLY A 105      11.701  -5.871 189.979  1.00 17.27           N  
ATOM    593  CA  GLY A 105      10.890  -5.284 188.908  1.00 18.60           C  
ATOM    594  C   GLY A 105      11.644  -4.255 188.065  1.00 19.98           C  
ATOM    595  O   GLY A 105      11.048  -3.645 187.173  1.00 22.07           O  
ATOM    596  N   ASP A 106      12.935  -4.086 188.330  1.00 20.37           N  
ATOM    597  CA  ASP A 106      13.774  -3.098 187.657  1.00 21.55           C  
ATOM    598  C   ASP A 106      15.045  -3.694 187.060  1.00 20.79           C  
ATOM    599  O   ASP A 106      16.004  -2.953 186.833  1.00 22.06           O  
ATOM    600  CB  ASP A 106      14.163  -2.000 188.663  1.00 22.71           C  
ATOM    601  CG  ASP A 106      15.060  -2.513 189.784  1.00 23.61           C  
ATOM    602  OD1 ASP A 106      15.318  -3.749 189.874  1.00 22.14           O  
ATOM    603  OD2 ASP A 106      15.528  -1.675 190.579  1.00 26.12           O  
ATOM    604  N   GLY A 107      15.085  -5.013 186.859  1.00 18.62           N  
ATOM    605  CA  GLY A 107      16.292  -5.707 186.387  1.00 18.23           C  
ATOM    606  C   GLY A 107      17.179  -6.295 187.480  1.00 17.02           C  
ATOM    607  O   GLY A 107      18.121  -7.018 187.181  1.00 17.38           O  
ATOM    608  N   SER A 108      16.868  -5.985 188.749  1.00 15.43           N  
ATOM    609  CA ASER A 108      17.622  -6.495 189.893  0.50 15.05           C  
ATOM    610  CA BSER A 108      17.620  -6.504 189.893  0.50 15.46           C  
ATOM    611  C   SER A 108      16.777  -7.474 190.704  1.00 14.87           C  
ATOM    612  O   SER A 108      15.569  -7.603 190.485  1.00 14.80           O  
ATOM    613  CB ASER A 108      18.121  -5.343 190.777  0.50 15.30           C  
ATOM    614  CB BSER A 108      18.133  -5.367 190.785  0.50 16.19           C  
ATOM    615  OG ASER A 108      19.014  -4.484 190.070  0.50 14.56           O  
ATOM    616  OG BSER A 108      17.080  -4.697 191.454  0.50 16.60           O  
ATOM    617  N   MET A 109      17.437  -8.176 191.617  1.00 14.38           N  
ATOM    618  CA  MET A 109      16.754  -9.100 192.512  1.00 14.14           C  
ATOM    619  C   MET A 109      17.295  -8.975 193.918  1.00 14.22           C  
ATOM    620  O   MET A 109      18.451  -8.556 194.139  1.00 14.16           O  
ATOM    621  CB  MET A 109      16.943 -10.536 192.044  1.00 14.33           C  
ATOM    622  CG  MET A 109      18.401 -10.981 192.032  1.00 14.80           C  
ATOM    623  SD  MET A 109      18.628 -12.679 191.523  1.00 15.99           S  
ATOM    624  CE  MET A 109      20.419 -12.756 191.529  1.00 16.53           C  
ATOM    625  N   VAL A 110      16.479  -9.415 194.867  1.00 13.66           N  
ATOM    626  CA  VAL A 110      16.955  -9.715 196.218  1.00 13.56           C  
ATOM    627  C   VAL A 110      17.294 -11.191 196.242  1.00 13.55           C  
ATOM    628  O   VAL A 110      16.492 -12.016 195.781  1.00 13.11           O  
ATOM    629  CB  VAL A 110      15.903  -9.426 197.309  1.00 13.34           C  
ATOM    630  CG1 VAL A 110      16.575  -9.511 198.683  1.00 13.66           C  
ATOM    631  CG2 VAL A 110      15.267  -8.062 197.101  1.00 13.14           C  
ATOM    632  N   HIS A 111      18.490 -11.542 196.724  1.00 14.04           N  
ATOM    633  CA  HIS A 111      18.869 -12.965 196.796  1.00 15.38           C  
ATOM    634  C   HIS A 111      19.810 -13.257 197.944  1.00 15.44           C  
ATOM    635  O   HIS A 111      20.450 -12.351 198.460  1.00 15.13           O  
ATOM    636  CB  HIS A 111      19.437 -13.484 195.460  1.00 16.08           C  
ATOM    637  CG  HIS A 111      20.837 -13.029 195.147  1.00 16.57           C  
ATOM    638  ND1 HIS A 111      21.773 -13.857 194.563  1.00 17.43           N  
ATOM    639  CD2 HIS A 111      21.463 -11.843 195.359  1.00 16.83           C  
ATOM    640  CE1 HIS A 111      22.909 -13.199 194.417  1.00 18.09           C  
ATOM    641  NE2 HIS A 111      22.752 -11.978 194.900  1.00 17.69           N  
ATOM    642  N   ALA A 112      19.823 -14.514 198.380  1.00 15.93           N  
ATOM    643  CA  ALA A 112      20.806 -15.033 199.335  1.00 17.35           C  
ATOM    644  C   ALA A 112      21.906 -15.662 198.465  1.00 18.11           C  
ATOM    645  O   ALA A 112      21.672 -16.697 197.862  1.00 18.35           O  
ATOM    646  CB  ALA A 112      20.180 -16.078 200.245  1.00 17.36           C  
ATOM    647  N   PRO A 113      23.085 -15.028 198.372  1.00 19.21           N  
ATOM    648  CA  PRO A 113      23.993 -15.392 197.261  1.00 19.98           C  
ATOM    649  C   PRO A 113      24.720 -16.741 197.368  1.00 20.19           C  
ATOM    650  O   PRO A 113      24.649 -17.565 196.444  1.00 22.96           O  
ATOM    651  CB  PRO A 113      24.991 -14.222 197.245  1.00 20.71           C  
ATOM    652  CG  PRO A 113      24.307 -13.116 197.990  1.00 21.28           C  
ATOM    653  CD  PRO A 113      23.539 -13.814 199.058  1.00 19.70           C  
ATOM    654  N   ARG A 114      25.381 -16.969 198.481  1.00 21.32           N  
ATOM    655  CA  ARG A 114      26.188 -18.170 198.687  1.00 22.91           C  
ATOM    656  C   ARG A 114      26.742 -18.133 200.091  1.00 22.78           C  
ATOM    657  O   ARG A 114      26.758 -17.061 200.694  1.00 22.75           O  
ATOM    658  CB  ARG A 114      27.365 -18.188 197.705  1.00 23.34           C  
ATOM    659  CG  ARG A 114      28.188 -16.909 197.729  1.00 24.01           C  
ATOM    660  CD  ARG A 114      29.489 -17.097 196.973  1.00 25.71           C  
ATOM    661  NE  ARG A 114      30.282 -15.866 196.918  1.00 25.74           N  
ATOM    662  CZ  ARG A 114      31.013 -15.363 197.919  1.00 28.97           C  
ATOM    663  NH1 ARG A 114      31.059 -15.963 199.114  1.00 27.59           N  
ATOM    664  NH2 ARG A 114      31.707 -14.235 197.722  1.00 29.53           N  
ATOM    665  N   PRO A 115      27.237 -19.288 200.611  1.00 23.43           N  
ATOM    666  CA  PRO A 115      27.901 -19.221 201.911  1.00 24.14           C  
ATOM    667  C   PRO A 115      28.987 -18.168 201.869  1.00 24.20           C  
ATOM    668  O   PRO A 115      29.698 -18.038 200.848  1.00 25.27           O  
ATOM    669  CB  PRO A 115      28.474 -20.637 202.103  1.00 25.47           C  
ATOM    670  CG  PRO A 115      27.649 -21.509 201.222  1.00 24.08           C  
ATOM    671  CD  PRO A 115      27.277 -20.653 200.047  1.00 24.84           C  
ATOM    672  N   GLY A 116      29.066 -17.387 202.928  1.00 23.03           N  
ATOM    673  CA  GLY A 116      30.004 -16.289 203.009  1.00 25.62           C  
ATOM    674  C   GLY A 116      29.529 -14.951 202.479  1.00 26.69           C  
ATOM    675  O   GLY A 116      30.296 -13.995 202.503  1.00 28.81           O  
ATOM    676  N   LYS A 117      28.288 -14.863 201.981  1.00 25.90           N  
ATOM    677  CA  LYS A 117      27.689 -13.568 201.637  1.00 27.54           C  
ATOM    678  C   LYS A 117      26.391 -13.397 202.426  1.00 25.13           C  
ATOM    679  O   LYS A 117      25.928 -14.333 203.046  1.00 28.88           O  
ATOM    680  CB  LYS A 117      27.456 -13.457 200.129  1.00 30.61           C  
ATOM    681  CG  LYS A 117      28.693 -12.949 199.382  1.00 32.48           C  
ATOM    682  CD  LYS A 117      28.471 -12.722 197.882  1.00 34.82           C  
ATOM    683  CE  LYS A 117      27.628 -11.491 197.565  1.00 36.21           C  
ATOM    684  NZ  LYS A 117      28.252 -10.197 197.968  1.00 38.14           N  
ATOM    685  N   THR A 118      25.850 -12.192 202.428  1.00 22.14           N  
ATOM    686  CA  THR A 118      24.561 -11.900 203.059  1.00 21.29           C  
ATOM    687  C   THR A 118      23.512 -11.565 201.997  1.00 19.36           C  
ATOM    688  O   THR A 118      23.829 -11.246 200.837  1.00 19.27           O  
ATOM    689  CB  THR A 118      24.672 -10.708 204.000  1.00 22.00           C  
ATOM    690  OG1 THR A 118      25.195  -9.611 203.262  1.00 24.99           O  
ATOM    691  CG2 THR A 118      25.603 -11.004 205.181  1.00 21.93           C  
ATOM    692  N   VAL A 119      22.251 -11.599 202.416  1.00 17.87           N  
ATOM    693  CA  VAL A 119      21.140 -11.253 201.516  1.00 16.60           C  
ATOM    694  C   VAL A 119      21.332  -9.832 201.001  1.00 16.44           C  
ATOM    695  O   VAL A 119      21.596  -8.910 201.762  1.00 15.95           O  
ATOM    696  CB  VAL A 119      19.767 -11.397 202.222  1.00 16.59           C  
ATOM    697  CG1 VAL A 119      18.634 -10.934 201.308  1.00 16.60           C  
ATOM    698  CG2 VAL A 119      19.541 -12.846 202.653  1.00 16.47           C  
ATOM    699  N   CYS A 120      21.194  -9.665 199.694  1.00 16.88           N  
ATOM    700  CA  CYS A 120      21.497  -8.393 199.051  1.00 17.82           C  
ATOM    701  C   CYS A 120      20.796  -8.274 197.717  1.00 17.29           C  
ATOM    702  O   CYS A 120      20.184  -9.229 197.236  1.00 16.32           O  
ATOM    703  CB  CYS A 120      23.011  -8.266 198.864  1.00 18.86           C  
ATOM    704  SG  CYS A 120      23.687  -9.460 197.710  1.00 20.56           S  
ATOM    705  N   ILE A 121      20.891  -7.083 197.122  1.00 17.79           N  
ATOM    706  CA  ILE A 121      20.329  -6.827 195.817  1.00 17.53           C  
ATOM    707  C   ILE A 121      21.458  -6.946 194.785  1.00 18.79           C  
ATOM    708  O   ILE A 121      22.570  -6.450 195.007  1.00 18.51           O  
ATOM    709  CB  ILE A 121      19.648  -5.443 195.757  1.00 18.05           C  
ATOM    710  CG1 ILE A 121      18.432  -5.441 196.689  1.00 18.85           C  
ATOM    711  CG2 ILE A 121      19.296  -5.057 194.314  1.00 18.01           C  
ATOM    712  CD1 ILE A 121      17.657  -4.149 196.766  1.00 19.75           C  
ATOM    713  N   LEU A 122      21.149  -7.609 193.676  1.00 17.43           N  
ATOM    714  CA  LEU A 122      22.089  -7.822 192.582  1.00 18.17           C  
ATOM    715  C   LEU A 122      21.354  -7.692 191.260  1.00 17.30           C  
ATOM    716  O   LEU A 122      20.230  -8.198 191.095  1.00 16.70           O  
ATOM    717  CB  LEU A 122      22.734  -9.212 192.660  1.00 18.92           C  
ATOM    718  CG  LEU A 122      23.831  -9.521 191.613  1.00 19.25           C  
ATOM    719  CD1 LEU A 122      25.082  -8.664 191.881  1.00 19.42           C  
ATOM    720  CD2 LEU A 122      24.186 -11.004 191.605  1.00 20.21           C  
ATOM    721  N   LYS A 123      21.993  -7.037 190.295  1.00 17.98           N  
ATOM    722  CA  LYS A 123      21.469  -7.005 188.931  1.00 18.16           C  
ATOM    723  C   LYS A 123      21.482  -8.423 188.376  1.00 18.07           C  
ATOM    724  O   LYS A 123      22.490  -9.115 188.445  1.00 18.45           O  
ATOM    725  CB  LYS A 123      22.286  -6.070 188.025  1.00 19.33           C  
ATOM    726  CG  LYS A 123      22.102  -4.605 188.369  1.00 20.63           C  
ATOM    727  N   ILE A 124      20.338  -8.846 187.845  1.00 17.70           N  
ATOM    728  CA  ILE A 124      20.131 -10.201 187.370  1.00 18.75           C  
ATOM    729  C   ILE A 124      21.152 -10.567 186.271  1.00 18.93           C  
ATOM    730  O   ILE A 124      21.649 -11.700 186.231  1.00 20.68           O  
ATOM    731  CB  ILE A 124      18.670 -10.379 186.867  1.00 17.91           C  
ATOM    732  CG1 ILE A 124      17.703 -10.333 188.075  1.00 17.79           C  
ATOM    733  CG2 ILE A 124      18.496 -11.691 186.092  1.00 18.20           C  
ATOM    734  CD1 ILE A 124      16.243 -10.129 187.721  1.00 17.79           C  
ATOM    735  N   ALA A 125      21.429  -9.600 185.396  1.00 21.56           N  
ATOM    736  CA  ALA A 125      22.419  -9.769 184.318  1.00 22.81           C  
ATOM    737  C   ALA A 125      23.820 -10.152 184.840  1.00 23.95           C  
ATOM    738  O   ALA A 125      24.561 -10.874 184.160  1.00 23.08           O  
ATOM    739  CB  ALA A 125      22.506  -8.495 183.486  1.00 23.35           C  
ATOM    740  N   TYR A 126      24.173  -9.700 186.050  1.00 24.60           N  
ATOM    741  CA  TYR A 126      25.489 -10.012 186.627  1.00 25.02           C  
ATOM    742  C   TYR A 126      25.710 -11.470 186.986  1.00 24.86           C  
ATOM    743  O   TYR A 126      26.853 -11.862 187.223  1.00 25.77           O  
ATOM    744  CB  TYR A 126      25.803  -9.130 187.846  1.00 27.10           C  
ATOM    745  CG  TYR A 126      25.956  -7.640 187.574  1.00 29.24           C  
ATOM    746  CD1 TYR A 126      25.909  -7.104 186.270  1.00 30.56           C  
ATOM    747  CD2 TYR A 126      26.173  -6.753 188.636  1.00 32.04           C  
ATOM    748  CE1 TYR A 126      26.057  -5.746 186.054  1.00 32.76           C  
ATOM    749  CE2 TYR A 126      26.323  -5.385 188.416  1.00 34.10           C  
ATOM    750  CZ  TYR A 126      26.269  -4.894 187.127  1.00 33.67           C  
ATOM    751  OH  TYR A 126      26.418  -3.550 186.903  1.00 37.06           O  
ATOM    752  N   MET A 127      24.653 -12.289 187.017  1.00 22.47           N  
ATOM    753  CA  MET A 127      24.839 -13.728 187.192  1.00 21.67           C  
ATOM    754  C   MET A 127      25.490 -14.357 185.960  1.00 22.00           C  
ATOM    755  O   MET A 127      26.038 -15.446 186.077  1.00 23.11           O  
ATOM    756  CB  MET A 127      23.523 -14.435 187.497  1.00 21.72           C  
ATOM    757  CG  MET A 127      22.891 -14.044 188.824  1.00 21.68           C  
ATOM    758  SD  MET A 127      23.797 -14.677 190.235  1.00 23.45           S  
ATOM    759  CE  MET A 127      23.449 -16.420 190.126  1.00 23.38           C  
ATOM    760  N   LYS A 128      25.407 -13.680 184.809  1.00 23.29           N  
ATOM    761  CA  LYS A 128      26.005 -14.135 183.540  1.00 25.33           C  
ATOM    762  C   LYS A 128      25.601 -15.577 183.221  1.00 25.46           C  
ATOM    763  O   LYS A 128      26.422 -16.430 182.859  1.00 26.16           O  
ATOM    764  CB  LYS A 128      27.527 -13.962 183.571  1.00 27.20           C  
ATOM    765  CG  LYS A 128      27.979 -12.511 183.620  1.00 28.15           C  
ATOM    766  CD  LYS A 128      29.473 -12.398 183.881  1.00 31.19           C  
ATOM    767  N   GLU A 129      24.309 -15.848 183.368  1.00 25.56           N  
ATOM    768  CA  GLU A 129      23.768 -17.144 182.992  1.00 24.91           C  
ATOM    769  C   GLU A 129      22.294 -17.093 182.684  1.00 22.92           C  
ATOM    770  O   GLU A 129      21.603 -16.097 182.968  1.00 22.43           O  
ATOM    771  CB  GLU A 129      24.073 -18.208 184.045  1.00 27.81           C  
ATOM    772  CG  GLU A 129      23.435 -18.013 185.395  1.00 30.42           C  
ATOM    773  CD  GLU A 129      23.827 -19.112 186.369  1.00 32.03           C  
ATOM    774  OE1 GLU A 129      23.567 -20.301 186.085  1.00 33.14           O  
ATOM    775  OE2 GLU A 129      24.394 -18.778 187.428  1.00 36.72           O  
ATOM    776  N   SER A 130      21.838 -18.179 182.076  1.00 21.19           N  
ATOM    777  CA ASER A 130      20.447 -18.366 181.698  0.50 21.16           C  
ATOM    778  CA BSER A 130      20.443 -18.306 181.680  0.50 21.33           C  
ATOM    779  C   SER A 130      19.522 -18.062 182.875  1.00 20.78           C  
ATOM    780  O   SER A 130      19.837 -18.442 184.029  1.00 19.98           O  
ATOM    781  CB ASER A 130      20.246 -19.810 181.238  0.50 20.74           C  
ATOM    782  CB BSER A 130      20.149 -19.664 181.022  0.50 21.07           C  
ATOM    783  OG ASER A 130      18.899 -20.081 180.927  0.50 21.36           O  
ATOM    784  OG BSER A 130      20.285 -20.753 181.916  0.50 22.25           O  
ATOM    785  N   TYR A 131      18.409 -17.393 182.589  1.00 20.00           N  
ATOM    786  CA  TYR A 131      17.418 -17.117 183.618  1.00 19.15           C  
ATOM    787  C   TYR A 131      16.027 -16.964 183.083  1.00 18.40           C  
ATOM    788  O   TYR A 131      15.825 -16.605 181.926  1.00 18.26           O  
ATOM    789  CB  TYR A 131      17.800 -15.868 184.416  1.00 19.66           C  
ATOM    790  CG  TYR A 131      17.818 -14.551 183.680  1.00 20.54           C  
ATOM    791  CD1 TYR A 131      18.925 -14.159 182.933  1.00 21.57           C  
ATOM    792  CD2 TYR A 131      16.754 -13.671 183.764  1.00 20.97           C  
ATOM    793  CE1 TYR A 131      18.959 -12.927 182.287  1.00 22.62           C  
ATOM    794  CE2 TYR A 131      16.787 -12.446 183.119  1.00 22.44           C  
ATOM    795  CZ  TYR A 131      17.890 -12.080 182.387  1.00 23.49           C  
ATOM    796  OH  TYR A 131      17.906 -10.856 181.758  1.00 26.45           O  
ATOM    797  N   GLY A 132      15.053 -17.245 183.947  1.00 17.56           N  
ATOM    798  CA  GLY A 132      13.649 -17.072 183.645  1.00 16.29           C  
ATOM    799  C   GLY A 132      12.862 -16.628 184.867  1.00 16.21           C  
ATOM    800  O   GLY A 132      13.434 -16.482 185.933  1.00 14.65           O  
ATOM    801  N   TYR A 133      11.553 -16.453 184.704  1.00 15.95           N  
ATOM    802  CA  TYR A 133      10.700 -15.917 185.771  1.00 15.86           C  
ATOM    803  C   TYR A 133       9.512 -16.804 186.011  1.00 16.15           C  
ATOM    804  O   TYR A 133       8.875 -17.255 185.031  1.00 16.38           O  
ATOM    805  CB  TYR A 133      10.172 -14.553 185.382  1.00 16.83           C  
ATOM    806  CG  TYR A 133      11.229 -13.551 185.023  1.00 16.89           C  
ATOM    807  CD1 TYR A 133      12.154 -13.113 185.963  1.00 18.01           C  
ATOM    808  CD2 TYR A 133      11.278 -12.995 183.754  1.00 17.68           C  
ATOM    809  CE1 TYR A 133      13.122 -12.179 185.634  1.00 18.54           C  
ATOM    810  CE2 TYR A 133      12.229 -12.065 183.425  1.00 18.91           C  
ATOM    811  CZ  TYR A 133      13.141 -11.657 184.370  1.00 19.37           C  
ATOM    812  OH  TYR A 133      14.076 -10.725 184.052  1.00 22.59           O  
ATOM    813  N   ARG A 134       9.204 -17.046 187.292  1.00 15.18           N  
ATOM    814  CA  ARG A 134       7.945 -17.638 187.712  1.00 14.96           C  
ATOM    815  C   ARG A 134       7.141 -16.664 188.564  1.00 15.57           C  
ATOM    816  O   ARG A 134       7.682 -15.712 189.136  1.00 15.27           O  
ATOM    817  CB  ARG A 134       8.138 -18.957 188.486  1.00 15.19           C  
ATOM    818  CG  ARG A 134       9.083 -19.980 187.862  1.00 16.16           C  
ATOM    819  CD  ARG A 134       8.612 -20.398 186.485  1.00 16.84           C  
ATOM    820  NE  ARG A 134       7.348 -21.129 186.528  1.00 17.87           N  
ATOM    821  CZ  ARG A 134       6.621 -21.454 185.459  1.00 19.40           C  
ATOM    822  NH1 ARG A 134       7.004 -21.081 184.242  1.00 20.93           N  
ATOM    823  NH2 ARG A 134       5.484 -22.124 185.605  1.00 20.49           N  
ATOM    824  N   ARG A 135       5.843 -16.938 188.681  1.00 15.29           N  
ATOM    825  CA  ARG A 135       4.948 -16.110 189.506  1.00 16.02           C  
ATOM    826  C   ARG A 135       4.077 -17.019 190.330  1.00 15.56           C  
ATOM    827  O   ARG A 135       3.404 -17.899 189.773  1.00 16.14           O  
ATOM    828  CB  ARG A 135       4.066 -15.254 188.613  1.00 17.31           C  
ATOM    829  CG  ARG A 135       3.032 -14.439 189.363  1.00 18.95           C  
ATOM    830  CD  ARG A 135       2.437 -13.351 188.466  1.00 20.89           C  
ATOM    831  NE  ARG A 135       3.481 -12.473 187.948  1.00 21.81           N  
ATOM    832  CZ  ARG A 135       3.356 -11.649 186.909  1.00 25.55           C  
ATOM    833  NH1 ARG A 135       4.390 -10.922 186.518  1.00 24.37           N  
ATOM    834  NH2 ARG A 135       2.204 -11.538 186.249  1.00 28.74           N  
ATOM    835  N   TYR A 136       4.049 -16.783 191.647  1.00 14.68           N  
ATOM    836  CA  TYR A 136       3.259 -17.610 192.561  1.00 15.13           C  
ATOM    837  C   TYR A 136       2.039 -16.926 193.195  1.00 16.29           C  
ATOM    838  O   TYR A 136       1.208 -17.609 193.804  1.00 16.99           O  
ATOM    839  CB  TYR A 136       4.177 -18.156 193.643  1.00 14.33           C  
ATOM    840  CG  TYR A 136       5.052 -19.290 193.186  1.00 14.63           C  
ATOM    841  CD1 TYR A 136       6.326 -19.047 192.646  1.00 14.74           C  
ATOM    842  CD2 TYR A 136       4.625 -20.610 193.312  1.00 14.49           C  
ATOM    843  CE1 TYR A 136       7.142 -20.104 192.233  1.00 15.15           C  
ATOM    844  CE2 TYR A 136       5.422 -21.664 192.911  1.00 14.71           C  
ATOM    845  CZ  TYR A 136       6.676 -21.408 192.373  1.00 14.85           C  
ATOM    846  OH  TYR A 136       7.463 -22.464 191.965  1.00 16.52           O  
ATOM    847  N   TYR A 137       1.948 -15.605 193.030  1.00 17.18           N  
ATOM    848  CA  TYR A 137       0.831 -14.780 193.525  1.00 18.30           C  
ATOM    849  C   TYR A 137      -0.183 -14.591 192.391  1.00 20.22           C  
ATOM    850  O   TYR A 137       0.025 -15.008 191.233  1.00 19.67           O  
ATOM    851  CB  TYR A 137       1.323 -13.411 194.063  1.00 18.43           C  
ATOM    852  CG  TYR A 137       2.057 -12.556 193.046  1.00 17.75           C  
ATOM    853  CD1 TYR A 137       3.421 -12.711 192.848  1.00 18.12           C  
ATOM    854  CD2 TYR A 137       1.381 -11.605 192.271  1.00 19.44           C  
ATOM    855  CE1 TYR A 137       4.106 -11.952 191.923  1.00 18.67           C  
ATOM    856  CE2 TYR A 137       2.058 -10.848 191.316  1.00 18.49           C  
ATOM    857  CZ  TYR A 137       3.428 -11.025 191.145  1.00 19.83           C  
ATOM    858  OH  TYR A 137       4.152 -10.303 190.200  1.00 20.70           O  
ATOM    859  OXT TYR A 137      -1.242 -13.985 192.608  1.00 21.40           O  
TER     860      TYR A 137                                                      
HETATM  861  C1  E64 A 201      21.360 -21.305 196.646  1.00 33.03           C  
HETATM  862  O1  E64 A 201      22.220 -20.999 195.774  1.00 33.76           O  
HETATM  863  O2  E64 A 201      21.492 -20.997 197.853  1.00 31.41           O  
HETATM  864  C2  E64 A 201      20.107 -22.056 196.227  1.00 32.08           C  
HETATM  865  C3  E64 A 201      19.781 -23.270 197.109  1.00 34.85           C  
HETATM  866  O3  E64 A 201      21.019 -23.912 197.472  1.00 37.24           O  
HETATM  867  C4  E64 A 201      18.869 -24.261 196.403  1.00 35.69           C  
HETATM  868  O4  E64 A 201      17.722 -24.480 196.785  1.00 34.20           O  
HETATM  869  N1  E64 A 201      19.366 -24.909 195.338  1.00 35.48           N  
HETATM  870  S   SO4 A 202       4.676 -22.197 181.711  1.00 50.39           S  
HETATM  871  O1  SO4 A 202       5.471 -23.399 181.375  1.00 52.93           O  
HETATM  872  O2  SO4 A 202       3.536 -22.076 180.784  1.00 54.94           O  
HETATM  873  O3  SO4 A 202       4.129 -22.313 183.081  1.00 49.60           O  
HETATM  874  O4  SO4 A 202       5.557 -21.032 181.545  1.00 47.25           O  
HETATM  875  O   HOH A 301       9.944 -12.871 210.509  1.00 26.14           O  
HETATM  876  O   HOH A 302       2.390 -20.429 182.994  1.00 36.18           O  
HETATM  877  O   HOH A 303       9.721  -0.903 199.419  1.00 25.36           O  
HETATM  878  O   HOH A 304      21.543 -13.201 209.955  1.00 18.72           O  
HETATM  879  O   HOH A 305      -1.743 -13.332 200.286  1.00 24.86           O  
HETATM  880  O   HOH A 306      14.522 -11.713 212.231  1.00 31.20           O  
HETATM  881  O   HOH A 307      18.428 -25.892 200.697  1.00 32.59           O  
HETATM  882  O   HOH A 308      23.725  -7.504 202.719  1.00 30.62           O  
HETATM  883  O   HOH A 309      19.997  -9.306 181.403  1.00 35.70           O  
HETATM  884  O   HOH A 310       5.927 -11.477 210.143  1.00 18.81           O  
HETATM  885  O   HOH A 311      17.715  -8.476 182.928  1.00 45.13           O  
HETATM  886  O   HOH A 312       1.890 -25.798 195.139  1.00 30.96           O  
HETATM  887  O   HOH A 313       8.812 -10.962 207.623  1.00 16.34           O  
HETATM  888  O   HOH A 314      31.793 -13.022 195.351  1.00 29.67           O  
HETATM  889  O   HOH A 315       3.565 -24.953 187.651  1.00 42.43           O  
HETATM  890  O   HOH A 316      14.480 -26.511 187.611  1.00 21.26           O  
HETATM  891  O   HOH A 317      19.581  -7.313 184.956  1.00 21.88           O  
HETATM  892  O   HOH A 318       6.908  -2.699 194.504  1.00 31.16           O  
HETATM  893  O   HOH A 319       7.966 -16.509 182.031  1.00 30.28           O  
HETATM  894  O   HOH A 320       1.366 -20.207 194.776  1.00 20.05           O  
HETATM  895  O   HOH A 321      17.471  -7.669 207.464  1.00 16.52           O  
HETATM  896  O   HOH A 322      10.111 -23.378 184.233  1.00 30.11           O  
HETATM  897  O   HOH A 323      17.570 -15.989 196.939  1.00 14.65           O  
HETATM  898  O   HOH A 324      16.388  -2.633 193.095  1.00 31.91           O  
HETATM  899  O   HOH A 325       7.528 -27.270 191.203  1.00 29.34           O  
HETATM  900  O   HOH A 326      31.556 -19.250 199.241  1.00 30.58           O  
HETATM  901  O   HOH A 327      13.804  -7.281 188.413  1.00 19.01           O  
HETATM  902  O   HOH A 328       5.978 -15.185 192.916  1.00 12.28           O  
HETATM  903  O   HOH A 329       2.698  -8.379 188.897  1.00 39.14           O  
HETATM  904  O   HOH A 330      24.791 -20.305 196.538  1.00 35.50           O  
HETATM  905  O   HOH A 331      15.168 -21.189 208.672  1.00 17.25           O  
HETATM  906  O   HOH A 332      18.603  -3.031 187.743  1.00 31.40           O  
HETATM  907  O   HOH A 333      -1.852 -10.871 199.313  1.00 35.51           O  
HETATM  908  O   HOH A 334       4.177  -7.100 190.919  1.00 26.03           O  
HETATM  909  O   HOH A 335      16.962 -26.754 206.927  1.00 26.92           O  
HETATM  910  O   HOH A 336      -1.356 -17.526 194.888  1.00 27.41           O  
HETATM  911  O   HOH A 337       4.371 -20.770 199.920  1.00 11.30           O  
HETATM  912  O   HOH A 338      12.926 -22.663 181.865  1.00 33.50           O  
HETATM  913  O   HOH A 339      26.311 -10.096 200.201  1.00 32.02           O  
HETATM  914  O   HOH A 340      22.161 -13.561 184.089  1.00 21.45           O  
HETATM  915  O   HOH A 341      25.396 -10.981 195.083  1.00 21.59           O  
HETATM  916  O   HOH A 342      20.545  -4.926 207.216  1.00 42.47           O  
HETATM  917  O   HOH A 343       2.968 -24.524 191.695  1.00 32.76           O  
HETATM  918  O   HOH A 344      19.805 -23.520 181.439  1.00 33.05           O  
HETATM  919  O   HOH A 345       7.918 -25.579 200.535  1.00 15.15           O  
HETATM  920  O   HOH A 346      17.362 -20.647 183.304  1.00 32.77           O  
HETATM  921  O   HOH A 347      -1.224 -18.929 197.134  1.00 23.83           O  
HETATM  922  O   HOH A 348      15.887 -26.757 204.426  1.00 17.86           O  
HETATM  923  O   HOH A 349       8.301  -4.358 186.612  1.00 38.67           O  
HETATM  924  O   HOH A 350       7.275  -4.427 188.993  1.00 20.63           O  
HETATM  925  O   HOH A 351      16.716 -18.182 210.762  1.00 21.26           O  
HETATM  926  O   HOH A 352      17.745 -26.957 193.728  1.00 24.29           O  
HETATM  927  O   HOH A 353      10.798 -16.486 181.820  1.00 24.45           O  
HETATM  928  O   HOH A 354      14.517 -24.710 178.641  1.00 20.69           O  
HETATM  929  O   HOH A 355      12.097 -10.210 211.621  1.00 21.63           O  
HETATM  930  O   HOH A 356      21.907  -4.872 198.881  1.00 25.17           O  
HETATM  931  O   HOH A 357      24.209  -5.092 191.217  1.00 23.92           O  
HETATM  932  O   HOH A 358      13.470  -8.559 186.180  1.00 34.83           O  
HETATM  933  O   HOH A 359      25.070 -16.251 193.655  1.00 36.39           O  
HETATM  934  O   HOH A 360       6.844  -0.997 197.459  1.00 21.50           O  
HETATM  935  O   HOH A 361      18.484  -7.225 209.954  1.00 26.45           O  
HETATM  936  O   HOH A 362      23.045 -12.871 181.627  1.00 29.50           O  
HETATM  937  O   HOH A 363      -0.757 -10.716 204.169  1.00 25.13           O  
HETATM  938  O   HOH A 364      12.376 -24.622 184.012  1.00 43.20           O  
CONECT  237  864                                                                
CONECT  861  862  863  864                                                      
CONECT  862  861                                                                
CONECT  863  861                                                                
CONECT  864  237  861  865                                                      
CONECT  865  864  866  867                                                      
CONECT  866  865                                                                
CONECT  867  865  868  869                                                      
CONECT  868  867                                                                
CONECT  869  867                                                                
CONECT  870  871  872  873  874                                                 
CONECT  871  870                                                                
CONECT  872  870                                                                
CONECT  873  870                                                                
CONECT  874  870                                                                
MASTER      284    0    2    4    8    0    0    6  913    1   15   10          
END                                                                             
