SARS-CoV-2 Omicron BA.4 spike trimer (6P) in complex with D1F6 Fab, focused refinement of RBD region

N-acetyl-beta-D-glucosamine; 2-acetamido-2-deoxy-beta-D-glucose; 2-acetamido-2-deoxy-D-glucose; 2-acetamido-2-deoxy-glucose; N-ACETYL-D-GLUCOSAMINE

An unconventional VH1-2 antibody tolerates escape mutations and shows an antigenic hotspot on SARS-CoV-2 spike.

Severe acute respiratory syndrome coronavirus 2

ITNLCPFDEVFNATRFASVYAWNRKRISNCVADYSVLYNFAPFFAFKCYGVSPTKLNDLCFTNVYADSFVIRGNEVSQIA
PGQTGNIADYNYKLPDDFTGCVIAWNSNKLDSKVGGNYNYRYRLFRKSNLKPFERDISTEIYQAGNKPCNGVAGVNCYFP
LQSYGFRPTYGVGHQPYRVVVLSFELLHAPATVCGP

QPVLTQPPSASGPPGQSVSISCSGSRSNIGTNFVYWYQQLPGAAPKLLIYKNDQRPSGVPERFFGSKSGTSASLAISGLR
SEDEVDYYCAAWDDSLSGHVFGAGTKVTVL

EVQLVQSGAEVKKPGASVKVSCKASGYIFSDYNIHWVRQAPGQGLEWMGWISPDSDDTNYAQSFQGRVTMTRDTSITTVY
MELSSLRSDDTAVYFCARSVGYCSLNSCQRWMWFDTWGQGALVTVSS

Spike protein, Antibody Fab fragment, Complex, VIRAL PROTEIN/IMMUNE SYSTEM, VIRAL PROTEIN-IMMUNE SYSTEM complex

ITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIA
PGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFP
LQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGP