Structure of NRAP-1 and its role in NMDAR signaling

Functional and Structural Studies of NRAP-1 and NMDAR signaling

GFSIRDIINGKRGADAATPCPTWHPFACPSGECVPIKYLCDGSPDCSDEYDENKSMCTAATRPPVEETQAFLKALMSAHG
KDFLVKVFGPKAKAELSGMGGVDKVAVALSQTPTADLFASEMKLDDGETQHMLEVMEGILNGSTDELTSNEAADFRFFVQ
KLQETGFF

17 mg/mL purified NRAP-1 in 150 mM sodium chloride, 15 mM HEPES, 1 mM calcium chloride, pH 7.35, 1:1 with crystallization solution (26% PEG8000, 100 mM CHES, pH 9.8)

National Institutes of Health/National Institute of Neurological Disorders and Stroke (NIH/NINDS)

AUC indicates clearly that the protein is monomeric in solution.

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS U VALUES : WITH TLS ADDED

NMDAR, NRAP-1, Synapse, Postsynaptic, Neurotransmitter, SIGNALING PROTEIN

FSIRDIINGKRGADAATPCPTWHPFACPSGECVPIKYLCDGSPDCSDEYDENKSMCTAATRPPVEETQAFLKALMSAHGK
DFLVKVFGPKAKAELSGMGGVDKVAVALSQTPTADLFASEMKLDDGETQHMLEVMEGILNGSTDELTSNEAADFRFFVQK
LQETGFF