Crystal structure of RNA G2C4 repeats in complex with small synthetic molecule ANP77
2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
Antisense RNA C9orf72 hexanucleotide repeat associated with amyotrophic lateral sclerosis and frontotemporal dementia forms a triplex-like structure and binds small synthetic ligand.
0.08 M NaCl, 0.04 M Na cacodylate trihydrate pH 6.0, 45% v/v MPD, 0.012 M Spermine tetrahydrochloride
RNA, G2C4 repeats, ALS, FTD, hexanucleotide repeats