Crystal structure of E. coli LpxH in complex with lipid X

(R)-((2R,3S,4R,5R,6R)-3-HYDROXY-2-(HYDROXYMETHYL)-5-((R)-3-HYDROXYTETRADECANAMIDO)-6-(PHOSPHONOOXY)TETRAHYDRO-2H-PYRAN-4-YL) 3-HYDROXYTETRADECANOATE

Antibiotic class with potent in vivo activity targeting lipopolysaccharide synthesis in Gram-negative bacteria.

quasi-periodic elliptically polarizing undulator (qEPU)

MATLFIADLHLCVEEPAITAGFLRFLAEEARKADALYILGDLFEAWIGDDDPNPLHRQMAAAIKAVSDSGVPCYFIHGNR
DFLLGKRFARESGMTLLPEEKVLELYGRRVLIMHGDTLCTDDAGYQAFRAKVHKPWLQMLFLALPLFVRKRIAARMRANS
KEANSSKSLAIMDVNQNAVVSAMEKHQVQWLIHGHTHRPAVHELIANQQPAFRVVLGAWHTEGSMVKVTADDVELIHFPF
HHHHHH

Morpheus III (G7)
1.2 % Cholic acid derivatives mix
0.1 M Buffer System 2 7.5
50 % Precipitant Mix 3

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS

Lipid A biosynthesis pathway Endotoxin UDP-diacyl-glucosamine Lipid X Gram-negative bacteria Lipopolysaccharides HYDROLASE, HYDROLASE

MATLFIADLHLCVEEPAITAGFLRFLAGEARKADALYILGDLFEAWIGDDDPNPLHRQMAAAIKAVSDSGVPCYFIHGNR
DFLLGKRFARESGMTLLPEEKVLELYGRRVLIMHGDTLCTDDAGYQAFRAKVHKPWLQMLFLALPLFVRKRIAARMRANS
KEANSSKSLAIMDVNQNAVVSAMEKHQVQWLIHGHTHRPAVHELIANQQPAFRVVLGAWHTEGSMVKVTADDVELIHFPF