Cereblon isoform 4 in complex with novel Benzamide-Type Cereblon Binder 11e

Leveraging Ligand Affinity and Properties: Discovery of Novel Benzamide-Type Cereblon Binders for the Design of PROTACs.

GASIFRCRQCGQTISRRDWLLPMGGDHEHVVFNPAGMIFRVWCFSLAQGLRLIGAPSGEFSWFKGYDWTIALCGQCGSHL
GWHYEGGSQPQTFFGLIKDRLAEGPA

HYDROGENS HAVE BEEN ADDED IN THEIR
RIDING POSITIONS

Cereblon, PROTAC, E3, molecular glue, SIGNALING PROTEIN