Crystal structure of human MMP-7 in complex with inhibitor

4-chloranyl-3-(trifluoromethyl)benzenesulfonic acid

Structure-Based Optimization and Biological Evaluation of Potent and Selective MMP-7 Inhibitors for Kidney Fibrosis.

Matrin,Matrix metalloproteinase-7,MMP-7,Pump-1 protease,Uterine metalloproteinase

MGYSLFPNSPKWTSKVVTYRIVSYTRDLPHITVDRLVSKALNMWGKEIPLHFRKVVWGTADIMIGFARGAHGDSYPFDGP
GNTLAHAFAPGTGLGGDAHFDEDERWTDGSSLGINFLYAATHQLGHSLGMGHSSDPNAVMYPTYGNGDPQNFKLSQDDIK
GIQKLYGKRSNSRKK

10% w/v Polyethylene glycol 8000, 100mM Tris pH7.0, 200mM Magnesium chloride

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS

Matrilysin, Matrin, Matrix metalloproteinase-7, Pump-1 protease, Uterine metalloproteinase, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR complex

YSLFPNSPKWTSKVVTYRIVSYTRDLPHITVDRLVSKALNMWGKEIPLHFRKVVWGTADIMIGFARGAHGDSYPFDGPGN
TLAHAFAPGTGLGGDAHFDEDERWTDGSSLGINFLYAATHELGHSLGMGHSSDPNAVMYPTYGNGDPQNFKLSQDDIKGI
QKLYGKRSNSRKK