Adenylation domain structure from NRPS-like Delta-Poly-L-Ornithine synthetase (L-Lysine bound)

2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.

Structural and functional insights into delta-poly-L-ornithine polymer biosynthesis from Acinetobacter baumannii.

GHMNQFVTNTKNVIRGKYHPEFLQNEVLADIFAHTAQTLPDKTALIEADKTLSYGELYQQALIMAQHLALKGVKPGHIVG
LWLPRGIELLKAQLAICLSGAAWLPFDMDTPADRIAVCLEDAEAVGMITTDEWYEHLAEVPQTKWTNTELQKPLSESVSL
AKTTPDQPAYIIYTSGSTGKPKGIVITQKNICHFLRSENSILGIQEQDKVYQGFSVAFDMSFEEIWLSYLVGATLWIAPK
SLVSDPERLCQTLKQEQITVLHAVPTLLALFPEDVPNLRIINLGGEMCPDSLVDRWALPHHQMFNTYGPTETTVSASLEL
LERGKPVTIGKPLPNYGMLVINSERELLEQGETGELCIFGPSVAQGYLGRPDLTADKFIENPWAMSVEEELLYRTGDLAK
IDEFGQVHCLGRA

0.1 M Amm Bromide, 0.1 M BTP pH 7.0, 24% PEG 20K

National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)

Apo structure 8G95 was used as search model

Adenylation domain, NRPS, delta-poly-L-ornithine synthetase, LIGASE, nonribosomal peptide synthetase

(chain 'A' and ((resid 8 through 9 and (name N or name CA or name C or name O or name CB )) or resid 10 through 71 or (resid 72 and (name N or name CA or name C or name O or name CB )) or resid 73 through 110 or (resid 111 and (name N or name CA or name C or name O or name CB )) or resid 112 through 117 or (resid 118 and (name N or name CA or name C or name O or name CB )) or resid 119 through 172 or (resid 173 through 178 and (name N or name CA or name C or name O or name CB )) or resid 179 through 322 or (resid 323 and (name N or name CA or name C or name O or name CB )) or resid 324 through 328 or (resid 329 and (name N or name CA or name C or name O or name CB )) or resid 330 through 343 or (resid 344 through 347 and (name N or name CA or name C or name O or name CB )) or resid 348 through 373 or (resid 374 and (name N or name CA or name C or name O or name CB )) or resid 375 through 391 or (resid 392 and (name N or name CA or name C or name O or name CB )) or resid 393 through 395 or (resid 396 through 398 and (name N or name CA or name C or name O or name CB )) or resid 399 through 400 or (resid 401 through 402 and (name N or name CA or name C or name O or name CB )) or resid 403 through 409 or (resid 410 through 411 and (name N or name CA or name C or name O or name CB ))))

(chain 'B' and (resid 8 through 129 or (resid 130 and (name N or name CA or name C or name O or name CB )) or resid 131 through 173 or (resid 178 and (name N or name CA or name C or name O or name CB )) or resid 179 through 254 or (resid 255 and (name N or name CA or name C or name O or name CB )) or resid 256 through 274 or (resid 275 and (name N or name CA or name C or name O or name CB )) or resid 276 through 292 or (resid 293 and (name N or name CA or name C or name O or name CB )) or resid 294 through 320 or (resid 321 and (name N or name CA or name C or name O or name CB )) or resid 322 through 411))

MNQFVTNTKNVIRGKYHPEFLQNEVLADIFAHTAQTLPDKTALIEADKTLSYGELYQQALIMAQHLALKGVKPGHIVGLW
LPRGIELLKAQLAICLSGAAWLPFDMDTPADRIAVCLEDAEAVGMITTDEWYEHLAEVPQTKWTNTELQKPLSESVSLAK
TTPDQPAYIIYTSGSTGKPKGIVITQKNICHFLRSENSILGIQEQDKVYQGFSVAFDMSFEEIWLSYLVGATLWIAPKSL
VSDPERLCQTLKQEQITVLHAVPTLLALFPEDVPNLRIINLGGEMCPDSLVDRWALPHHQMFNTYGPTETTVSASLELLE
RGKPVTIGKPLPNYGMLVINSERELLEQGETGELCIFGPSVAQGYLGRPDLTADKFIENPWAMSVEEELLYRTGDLAKID
EFGQVHCLGRA