Solution NMR structure of 8-residue Rosetta-designed cyclic peptide D8.31 in d6-DMSO with cis/trans switching (B-CT conformation)
Accurate de novo design of membrane-traversing macrocycles.
Cyclic peptide D8.31 DAL-DPR-MLU-DVA-DAL-DPR-MLU-DVA
National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)
This is conformation B (CT) of the 8-residue cyclic peptide present in the same NMR sample in d6-DMSO. A-CC conformation (50%) has cis MLU-3 and cis MLU-7 (pdb 7UBD) and B-CT (50%) conformation has cis MLU-3 and trans MLU-7
Delaglio, Grzesiek, Vuister, Zhu, Pfeifer and Bax
Tejero, Snyder, Mao, Aramini, Montelione
cyclic peptide with two conformations observed in noesy data. A-CC (50%) and B-CT (50%). This one is B-CT conformation.
cyclic peptide, non natural amino acids, cis/trans, switch peptides, de novo design, membrane permeability, DE NOVO PROTEIN