Crystal structure of arsenoplatin-1/B-DNA adduct obtained upon 48 h of soaking
On the mechanism of action of arsenoplatins: arsenoplatin-1 binding to a B-DNA dodecamer.
DNA (5'-D(*CP*GP*CP*GP*AP*AP*TP*TP*CP*GP*CP*G)-3')
MPD 7 % v/v, MgCl2 20 mM, spermine tetrahydrochloride 80 mM, sodium cacodylate 60 mM, pH 6.5. Equilibrated against a reservoir containing MPD 50 % v/v
arsenoplatin-1/B-DNA adduct (4 h soaking)
Duplex, B-DNA, Arsenoplatin-1, Anticancer agent, Metallodrug, DNA