Decrypting the programming of beta-methylation in virginiamycin M biosynthesis.
Hybrid non ribosomal peptide synthetase-polyketide synthase
GPGSMYGEAVTEQLSRLVAGFVPDAAGSVDPDRTLLEHGIDSINLMNLRFEITERFGRTLPLQLLSESTVPVLAAHLSAD RAH
Hybrid polyketide synthase-non ribosomal peptide synthetase ACP7
1.6 mM [U-100% 13C; U-100% 15N] Hybrid polyketide synthase-non ribosomal peptide synthetase ACP7, 100 mM sodium phosphate, 1 mM TCEP, 90% H2O/10% D2O
Case, Darden, Cheatham III, Simmerling, Wang, Duke, Luo, ... and Kollman