Crystal structure of YTHDF2 with compound ZA_143

2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.

Fragment Ligands of the m 6 A-RNA Reader YTHDF2.

CLL-associated antigen KW-14,High-glucose-regulated protein 8,Renal carcinoma antigen NY-REN-2

MGSSYHHHHHHSSGENLYFQHMKHGRVFIIKSYSEDDIHRSIKYNIWCSTEHGNKRLDAAYRSMNGKGPVYLLFSVNGSG
HFCGVAEMKSAVDYNTCAGVWSQDKWKGRFDVRWIFVKDVPNSQLRHIRLENNENKPVTNSRDTQEVPLEKAKQVLKIIA
SYKHTTS

2.05 M Ammonium sulfate, 0.1 M Sodium citrate tribasic pH 5.1

epitranscriptomic reader, m6A reader, RNA BINDING PROTEIN

KHGRVFIIKSYSEDDIHRSIKYNIWCSTEHGNKRLDAAYRSMNGKGPVYLLFSVNGSGHFCGVAEMKSAVDYNTCAGVWS
QDKWKGRFDVRWIFVKDVPNSQLRHIRLENNENKPVTNSRDTQEVPLEKAKQVLKIIASYKHTTS