Crystal structure of a HDAC4-MEF2A-DNA ternary complex

Structural insights into transcription regulation by the higher-order HDAC4-MEF2-DNA complex

myocyte-specific enhancer factor 2A isoform X4

DNA (5'-D(P*AP*CP*TP*AP*TP*TP*TP*AP*TP*AP*A)-3')

DNA (5'-D(*TP*CP*TP*TP*AP*TP*AP*AP*AP*TP*AP*GP*T)-3')

GPAEPALREQQLQQELLALKQKQQIQRQILIAEFQRQHEQLSRQHEAQLHEHIKQQQEMLAMKHQQELLEHQRKLERHRQ
EQELEKQHREQKLQQLKNKEKGKESAVASTEVKMKLQEFVLNKKKALAHRNLN

GPMGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSSNKLFQYASTDMDKVLLKYTEYNEPHES
RTNSDIVEALNKKEHRG

0 mM HEPES pH 7.5, 0.2 M NaCl, 3% (v/v) PEG 4000

National Natural Science Foundation of China (NSFC)

National Institutes of Health/National Cancer Institute (NIH/NCI)

HDAC4, MEF2, transcription repressor, TRANSCRIPTION

AEPALREQQLQQELLALKQKQQIQRQILIAEFQRQHEQLSRQHEAQLHEHIKQQQEMLAMKHQQELLEHQRKLERHRQEQ
ELEKQHREQKLQQLKNKEKGKESAVASTEVKMKLQEFVLNKKKALAHRNLN

MGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSSNKLFQYASTDMDKVLLKYTEYNEPHESRT
NSDIVEALNKKEHRG