Drimenyl diphosphate synthase D303A from Streptomyces showdoensis in complex with farnesyl diphosphate (FPP) and Mg2+

Discovery, Structure, and Mechanism of a Class II Sesquiterpene Cyclase.

SQHop_cyclase_C domain-containing protein

HHHHHHATAVVRCRTRLARRVVAAVGPDGLLPAPCESRVLESALALALLTEERAEADATARLTAYLRTTLRTAPPDPFQC
AVARAVLGGAGERGERVGDEGDMDAGTALDAGLDGFDHFTAGRKRLMFRTVLAALGATGFPAVPWEAYDTRPQQSWLHME
MKALKVLAAHGTGHPDVVRDEDWRALLPALEPGPAWECNNLAQLLALLALRHSPRHRPALGDVLKHVAGRLRPDGGMPFI
DGMTVFTTAAAGLALSLLPAPPACVTPMADALALRRNPDGGYGFHSGVAQSDVADTCYVLEFLRRAAPDRHRTAVAEAEG
YLLALRNPDGGFPTFARGTSSEIAMTAAAASALAHDPDRREEVDEAVRYVVRHQRPDGTFERSWSRNATNAVFRAVLALT
GVAAHGEERRSRARAAERALAHLAATQNGDGGWGHAEAEPSDPISTAYAVIALARGPRARPGGPLDRALAYLVERQHPDG
GYRSRPDQAGPRPLLYDVPALADVFVLLALAHAT

National Natural Science Foundation of China (NSFC)

the form that 7XQ4_D303A in complex with 2F-FPP and Mg2+with

the form that 7XQ4_D303E in complex with FPP and Mg2+with

Terpene synthases, type II TSs, BIOSYNTHETIC PROTEIN

ATAVVRCRTRLARRVVAAVGPDGLLPAPCESRVLESALALALLTEERAEADATARLTAYLRTTLRTAPPDPFQCAVARAV
LGGAGERGERVGDEGDMDAGTALDAGLDGFDHFTAGRKRLMFRTVLAALGATGFPAVPWEAYDTRPQQSWLHMEMKALKV
LAAHGTGHPDVVRDEDWRALLPALEPGPAWECNNLAQLLALLALRHSPRHRPALGDVLKHVAGRLRPDGGMPFIDGMTVF
TTAAAGLALSLLPAPPACVTPMADALALRRNPDGGYGFHSGVAQSDVDDTCYVLEFLRRAAPDRHRTAVAEAEGYLLALR
NPDGGFPTFARGTSSEIAMTAAAASALAHDPDRREEVDEAVRYVVRHQRPDGTFERSWSRNATNAVFRAVLALTGVAAHG
EERRSRARAAERALAHLAATQNGDGGWGHAEAEPSDPISTAYAVIALARGPRARPGGPLDRALAYLVERQHPDGGYRSRP
DQAGPRPLLYDVPALADVFVLLALAHAT