Crystal structure of a versatile ancestral ADH with high activity and thermostability

MSVLVSGATGFIAQHIVNVLLEQNYKVIGTVRSQEKADKLIKQFNNNPNLSFEIVPDIANLDAFDEVFKKHGKEIKYVIH
TASPVHFGTTDYEKDLLIPAVNGTKGILESIKKYAPDTVERVVITSSFAAIMDLNKQSDSSVIFTEKSWNPVTWENAQNA
ITAYCGSKTFAEKAAWDFLKENKDSVKFKLTTINPVFVFGPQLFDEDVKDKLNTSCEIINELLHAPPDTKVDKSSTCAGN
FIDVRDVAKAHVLAFQKDELIGKRLLLSNGPFSKQDIVNILNKDFPQLKGKIPPADPDTDAQKNNTTGCKIDNEKTKKLL
GFEFKSFEETVYDTVHQILKKEGKL

National Science Foundation (NSF, China)

Ancestral ADH, Diaryl ketones, Atropoenantioselectivity, OXIDOREDUCTASE