Cryo-EM structure of SARS-CoV-2 Delta variant spike protein in complex with three nAbs X01, X10 and X17

N-acetyl-beta-D-glucosamine; 2-acetamido-2-deoxy-beta-D-glucose; 2-acetamido-2-deoxy-D-glucose; 2-acetamido-2-deoxy-glucose; N-ACETYL-D-GLUCOSAMINE

The neutralizing breadth of antibodies targeting diverse conserved epitopes between SARS-CoV and SARS-CoV-2.

Severe acute respiratory syndrome coronavirus 2

ESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIR
GDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYRYRLFRKSNLKPFERDISTEIYQAGSKPCNGV
EGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGP

DIVLTQSPASLAVSLGQRAAISCRASQSVSTSSHNYVHWYQQRPGQPPKLLIKYASNLECGVPARFSGSGSGTDFTLNIH
PVEEEDSAAYYCQHSWEIPYTFGGGTKLEIK

EVQLQQSGPELVKPGASVKISCKTSGYTFTEYTLHWVKQSHGKSLEWIGGFDPNFGGATYNLKFEDKATLTVDKSSNTAY
MELRSLTSEDSAVFYCARGDYGTSYAYFDFWGQGTTLTVSS

DIQMTQTTSSLSASLGDRVTISCRASQDISNYLNWYQQKPDGTVKLLIYYTSRLHSGVPSRFSGSGSGTDYSLTISNLEQ
EDIATYFCQQGTTLPYTFGGGTKLEIK

QVQLQQSGAELARPGASVKLSCKASGYTFTFYWMQWLKQRPGQGLEWIGAIYPGDGDTRYTQRFKDKATLTADKSSSTAY
IQLSSLASEDSAVYYCAGGEYDNYGFDYWGQGTTLTVSS

DIQMTQSSSYLSVSLGGRVTITCKASDHINNWLAWYQQKPGNAPRLLISGVTNLETGVPSRFSGSGSGKNFTLSIASLQT
EDVATYYCQQYWSFPWTFGGGTKLEIR

EIQLQQSGPELVAPGASVKVSCKASGYAFTSYNMYWVRQSHGKSLEWIGYIVPYNGGTTYNQEFKGKATLTVDKSSNTAY
IHLNSLTSEDSAVYYCAKEGTYYGYDGVLADWGQGTLVT

SARS-CoV-2 Delta variant, Neutralizing antibody, Cryo-EM, VIRAL PROTEIN, VIRAL PROTEIN-IMMUNE SYSTEM complex

ESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIR
GDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGV
EGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGP