The crystal structure of rat calcium-dependent activator protein for secretion (CAPS) C2PH

The C 2 and PH domains of CAPS constitute an effective PI(4,5)P2-binding unit essential for Ca 2+ -regulated exocytosis.

Calcium-dependent activator protein for secretion 1,CAPS-1,rCAPS

DVLLSFSLEVVIMEVQGLKSLAPNRIVYCTMEVEGGEKLQTDQAEASKPTWGTQGDFSTTHALPAVKVKLFTESTGVLAL
EDKELGRVILHPTPNSPKQSEWHKMTVSKNCPDQDLKIKLAVRMDKPQNMKHSGYLWTIGKNVWKRWKKRFFVLVQVSQY
TFAMCSYREKKAEPQELLQLDGYTVDYTDPQPGLEGGRAFFNAVKEGDTVIFASDDEQDRILWVQAMYRATGQSHKPVPP
TQVQ

Escherichia coli 'BL21-Gold(DE3)pLysS AG'

National Natural Science Foundation of China (NSFC)

Ca2+-dependent exocytosis; Vesicle priming; Munc13; CAPS; SNARE complex assembly, EXOCYTOSIS