Thermostabilized human prestin in complex with chloride

(2R)-2-[(9Z)-9-Octadecenoyloxy]-3-(palmitoyloxy)propyl 2-(trimethylammonio)ethyl phosphate

Cryo-EM structures of thermostabilized prestin provide mechanistic insights underlying outer hair cell electromotility.

MDHAEENEILAATQRYVVERPVYSQELLEEELEKKDRVPKTLGDKLKKSFRCSPKKAKNLLLSFFPILEWLPKYNLKEWL
LGDLIAGLTVGSLQIPQGIAFALLAGLPPIYGLYSSFFPPLIYAFFGTSRHISVGPFAVVSLLVGSVVERLVPDDIVLPG
GVNATNGTEARDALRVQVAFTLTFLAGIIQLALGLLRLGFLVDFLSEPLISGFTTGAAIHILLSQLKYLLGLKIPRHSGP
FSVIYSVISVFHNIPNTNIATLGVSLLSFVLLLVVKELNKRFKKKLPVPIPAELIVVILATLISYYFNLAEKYGVSIVGH
IPKGLPPPSVPDLSLFPLVIGDAIAIAIVGLAVSISVGKTFAKKHGYQIDGNQELIALGLMNIVGSFFSCYPATGSFSRS
AVNESAGGKTQVAGIVAALVVLLVLLFLGPLFYYLPKAVLAAIIIVNLKGLLMQFKDAPKLWKVDKLDFLIWLVTFLGVV
FLSVEIGLLVGVGFSLLTVLLRTQRPRTSVLGRIPGTDIYRDVKQYPEAEEVPGVKIFRIDSPIYFANSEYFKERLKRKT
GVDPVKVLAARKKALKKIEKEIKKANLANKTVVKADAEVDGEDATKPEEEDGEVKYPPIVIQSDWPSELPRFVPPKVDFH
TLILDFSAVSFVDTVGVKTLKEIVKEYREIGVQVYLAGCNASVVEKLERGGFFDDGITKEHLFLSVHDAVLFAQARKALA
EQEASAPPSQEDLEPNATPATPEAGTENLYFQG

Japan Society for the Promotion of Science (JSPS)

Hydrogens have been added in their riding positions

motor protein, prestin, SLC26A5, electromotility, MEMBRANE PROTEIN