Integrin alaphIIBbeta3 complex with fradafiban (Mn/Ca)

2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.

1-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.

[(3S,5S)-5-{[(4'-carbamimidoyl[1,1'-biphenyl]-4-yl)oxy]methyl}-2-oxopyrrolidin-3-yl]acetic acid

N-acetyl-beta-D-glucosamine; 2-acetamido-2-deoxy-beta-D-glucose; 2-acetamido-2-deoxy-D-glucose; 2-acetamido-2-deoxy-glucose; N-ACETYL-D-GLUCOSAMINE

A general chemical principle for creating closure-stabilizing integrin inhibitors.

Platelet membrane glycoprotein IIIa,GPIIIa

LNLDPVQLTFYAGPNGSQFGFSLDFHKDSHGRVAIVVGAPRTLGPSQEETGGVFLCPWRAEGGQCPSLLFDLRDETRNVG
SQTLQTFKARQGLGASVVSWSDVIVACAPWQHWNVLEKTEEAEKTPVGSCFLAQPESGRRAEYSPCRGNTLSRIYVENDF
SWDKRYCEAGFSSVVTQAGELVLGAPGGYYFLGLLAQAPVADIFSSYRPGILLWHVSSQSLSFDSSNPEYFDGYWGYSVA
VGEFDGDLNTTEYVVGAPTWSWTLGAVEILDSYYQRLHRLRGEQMASYFGHSVAVTDVNGDGRHDLLVGAPLYMESRADR
KLAEVGRVYLFLQPRGPHALGAPSLLLTGTQLYGRFGSAIAPLGDLDRDGYNDIAVAAPYGGPSGRGQVLVFLGQSEGLR
SRPSQVLDSPFPTGSAFGFSLRGAVDIDDNGYPDLIVGAYGANQVAVYRAQPVVKAS

GPNICTTRGVSSCQQCLAVSPMCAWCSDEALPLGSPRCDLKENLLKDNCAPESIEFPVSEARVLEDRPLSDKGSGDSSQV
TQVSPQRIALRLRPDDSKNFSIQVRQVEDYPVDIYYLMDLSYSMKDDLWSIQNLGTKLATQMRKLTSNLRIGFGAFVDKP
VSPYMYISPPEALENPCYDMKTTCLPMFGYKHVLTLTDQVTRFNEEVKKQSVSRNRDAPEGGFDAIMQATVCDEKIGWRN
DASHLLVFTTDAKTHIALDGRLAGIVQPNDGQCHVGSDNHYSASTTMDYPSLGLMTEKLSQKNINLIFAVTENVVNLYQN
YSELIPGTTVGVLSMDSSNVLQLIVDAYGKIRSKVELEVRDLPEELSLSFNATCLNNEVIPGLKSCMGLKIGDTVSFSIE
AKVRGCPQEKEKSFTIKPVGFKDSLIVQVTFDCDCACQAQAEPNSHRCNNGNGTFECGVCRCGPGWLGSQCE

EVQLQQSGAELVKPGASVKLSCTASGFNIKDTYVHWVKQRPEQGLEWIGRIDPANGYTKYDPKFQGKATITADTSSNTAY
LQLSSLTSEDTAVYYCVRPLYDYYAMDYWGQGTSVTVSSAKTTAPSVYPLAPVCGDTTGSSVTLGCLVKGYFPEPVTLTW
NSGSLSSGVHTFPAVLQSDLYTLSSSVTVTSSTWPSQSITCNVAHPASSTKVDKKIEPRGP

DILMTQSPSSMSVSLGDTVSITCHASQGISSNIGWLQQKPGKSFMGLIYYGTNLVDGVPSRFSGSGSGADYSLTISSLDS
EDFADYYCVQYAQLPYTFGGGTKLEIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVL
NSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC

11% PEG 8000, 0.2 M ammonium sulfate, 0.1 M Tris-HCl

National Institutes of Health/National Heart, Lung, and Blood Institute (NIH/NHLBI)

chain 'A' and (resid 1 through 67 )
chain 'A' and (resid 68 through 313 )
chain 'A' and (resid 314 through 454 )
chain 'B' and (resid 1 through 111 )
chain 'B' and (resid 112 through 339 )
chain 'B' and (resid 340 through 431 )
chain 'B' and (resid 432 through 466 )
chain 'C' and (resid 1 through 67 )
chain 'C' and (resid 68 through 291 )
chain 'C' and (resid 292 through 453 )
chain 'D' and (resid 1 through 105 )
chain 'D' and (resid 106 through 339 )
chain 'D' and (resid 340 through 438 )
chain 'D' and (resid 439 through 471 )
chain 'E' and (resid 1 through 16 )
chain 'E' and (resid 17 through 32 )
chain 'E' and (resid 33 through 52 )
chain 'E' and (resid 53 through 67 )
chain 'E' and (resid 68 through 112 )
chain 'E' and (resid 113 through 125 )
chain 'E' and (resid 126 through 165 )
chain 'E' and (resid 166 through 175 )
chain 'E' and (resid 176 through 199 )
chain 'E' and (resid 200 through 219 )
chain 'F' and (resid 1 through 18 )
chain 'F' and (resid 19 through 38 )
chain 'F' and (resid 39 through 75 )
chain 'F' and (resid 76 through 102 )
chain 'F' and (resid 103 through 113 )
chain 'F' and (resid 114 through 129 )
chain 'F' and (resid 130 through 144 )
chain 'F' and (resid 145 through 155 )
chain 'F' and (resid 156 through 174 )
chain 'F' and (resid 175 through 214 )
chain 'H' and (resid 1 through 17 )
chain 'H' and (resid 18 through 60 )
chain 'H' and (resid 61 through 83 )
chain 'H' and (resid 84 through 125 )
chain 'H' and (resid 126 through 168 )
chain 'H' and (resid 169 through 179 )
chain 'H' and (resid 180 through 219 )
chain 'L' and (resid 1 through 18 )
chain 'L' and (resid 19 through 75 )
chain 'L' and (resid 76 through 90 )
chain 'L' and (resid 91 through 113 )
chain 'L' and (resid 114 through 155 )
chain 'L' and (resid 156 through 214 )
Complex, Inhibitor, BLOOD CLOTTING, CELL ADHESION, CELL ADHESION-INHIBITOR complex