Structural analysis of Atopobium parvulum SufS cysteine desulfurase linked to Crohn's disease.

MASSHHHHHHHENLYFQGMTDTEVAQITDNPYKADFPILAANPKVAYLDSAATSQRPRVVIEAQSRFYETMNANALRGLY
RWSVDATAAIEDARASIAKFIGAVDKNDKPESQQIIFTRNTSEALNLVASSLGRYALKPGDDVVISIMEHHSNIIPWQQI
CKATGANLVYLRMNSQYQITPEEIASKITERAKIVSVTHVSNVLGTRNDIKAIAKRTHAMGAYMVVDAAQSAPHILVNVH
DLDCDLLAFSAHKMCGPMGIGVLWGRAELLNAMPPFLTGGEMIDSVTETGAVWAPVPEKFEAGTQDAAGIYATGAAIKYL
NGLDMAKIEKREELLARYLVQQLCTLDFVDIVGSKLGQNHVGAVAFNVRGVHPHDVSSILDMNNVCIRAGHH(CSS)AEP
LLIELHESSTCRASVAFYNDKHDIDQLIEGLNQVWKIFGSAVNTKQNKELK

MASSHHHHHHHENLYFQGMTDTEVAQITDNPYKADFPILAANPKVAYLDSAATSQRPRVVIEAQSRFYETMNANALRGLY
RWSVDATAAIEDARASIAKFIGAVDKNDKPESQQIIFTRNTSEALNLVASSLGRYALKPGDDVVISIMEHHSNIIPWQQI
CKATGANLVYLRMNSQYQITPEEIASKITERAKIVSVTHVSNVLGTRNDIKAIAKRTHAMGAYMVVDAAQSAPHILVNVH
DLDCDLLAFSAHKMCGPMGIGVLWGRAELLNAMPPFLTGGEMIDSVTETGAVWAPVPEKFEAGTQDAAGIYATGAAIKYL
NGLDMAKIEKREELLARYLVQQLCTLDFVDIVGSKLGQNHVGAVAFNVRGVHPHDVSSILDMNNVCIRAGHHCAEPLLIE
LHESSTCRASVAFYNDKHDIDQLIEGLNQVWKIFGSAVNTKQNKELK

ALA from previous model removed due to bad ligand quality fit/density. Better Rfree and Clashscore in revised model.

Canadian Institutes of Health Research (CIHR)

MTDTEVAQITDNPYKADFPILAANPKVAYLDSAATSQRPRVVIEAQSRFYETMNANALRGLYRWSVDATAAIEDARASIA
KFIGAVDKNDKPESQQIIFTRNTSEALNLVASSLGRYALKPGDDVVISIMEHHSNIIPWQQICKATGANLVYLRMNSQYQ
ITPEEIASKITERAKIVSVTHVSNVLGTRNDIKAIAKRTHAMGAYMVVDAAQSAPHILVNVHDLDCDLLAFSAHKMCGPM
GIGVLWGRAELLNAMPPFLTGGEMIDSVTETGAVWAPVPEKFEAGTQDAAGIYATGAAIKYLNGLDMAKIEKREELLARY
LVQQLCTLDFVDIVGSKLGQNHVGAVAFNVRGVHPHDVSSILDMNNVCIRAGHHCAEPLLIELHESSTCRASVAFYNDKH
DIDQLIEGLNQVWKIFGSAVNTKQNKELK