Cardiac thin filament decorated with regulatory M-domain of cardiac myosin binding protein C

Cryo-Electron Microscopy Reveals Cardiac Myosin Binding Protein-C M-Domain Interactions with the Thin Filament.

Only triple helix motif of the M-domain is visible in the map. C1 domain is not bound and hence not visible in the map.
Complex of cardiac thin filament with C1-M fragment of cardiac myosin binding protein C (cMyBP-C)

PELCO Ultrathin Carbon with Lacey Carbon

only triple helix motif from C1-M construct bound to thin filament is visible in the map and contained in the model

Cardiac MyBP-C,C-protein,cardiac muscle isoform

DDEETTALVCDNGSGLVKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIITNWD
DMEKIWHHTFYNELRVAPEEHPTLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVT
HNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEKSY
ELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVLSGGTTMYPGIADRMQKEITAL
APSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDEAGPSIVHRKCF

DDPIGLFVMRPQDGEVTVGGSITFSARVAGASLLKPPVVKWFKGKWVDLSSKVGQHLQLHDSYDRASKVYLFELHITDAQ
PAFTGSYRCEVSTKDKFDCSNFNLTVHEAMGTGDLDLLSAFRRTSLAGGGRRISDSHEDTGILDFSSLLKKRDSFRTPRD
SKLEAPAEEDVWEILRQAPPSEYERIAFQYGVTDLRGMLKRLKGMRRDEKKSTAFQKKLE

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Atoms with unrealistic or zero occupancies

National Institutes of Health/National Heart, Lung, and Blood Institute (NIH/NHLBI)

National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)

cardiac contraction regulator, muscle protein, MOTOR PROTEIN