Crystal structure of SARS-CoV-2 neutralizing antibody WS6 in complex with spike S2 peptide

Vaccine-elicited murine antibody WS6 neutralizes diverse beta-coronaviruses by recognizing a helical stem supersite of vulnerability.

Anti-SARS-CoV-2 antibody WS6 Fab heavy chain

Anti-SARS-CoV-2 antibody WS6 Fab light chain

EVQFQQSGTVLARPGASVKMSCKASGYTFTNYWIHWVKQRPGQGLEYIGGTYPGNGDTTYNQKFKGKAKVTAVTPTSTAY
MDLSSLTNEDSAVYYCTRTGSYFDYWGQGTTLTVSSASTTAPSVYPLAPVCGDTTGSSVTLGCLVKGYFPEPVTLTWNSG
SLSSGVHTFPAVLQSDLYTLSSSVTVTSSTWPSQSITCNVAHPASSTKVDKKIEPR

(PCA)IVLTQSPAIMSASPGEKVTISCSATSSVSYIYWYQQRPGSSPKPWIYRTSNLASGVPVRFSGSGSGTSYSLTISN
MEAEDAATYYCQQYQSYPPTFGAGTKLELKRTDAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQN
GVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNE

QIVLTQSPAIMSASPGEKVTISCSATSSVSYIYWYQQRPGSSPKPWIYRTSNLASGVPVRFSGSGSGTSYSLTISNMEAE
DAATYYCQQYQSYPPTFGAGTKLELKRTDAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLN
SWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNE

National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID)

Severe acute respiratory syndrome coronavirus 2

(I2J) at the carboxy-terminus of the peptide (chains C and D) is a pegylation.
The amino-terminal glutamine of one of the light chains in the asymmetric unit (chain L) spontaneously formed pyroglutamate.

chain 'C' and (resid 1149 through 1157 )

chain 'D' and (resid 1149 through 1157 )

SARS-CoV-2, spike, antibody, VIRAL PROTEIN, VIRAL PROTEIN-IMMUNE SYSTEM complex