Crystal structure of D179N KPC-2 beta-lactamase

Structural Characterization of the D179N and D179Y Variants of KPC-2 beta-Lactamase: Omega-Loop Destabilization as a Mechanism of Resistance to Ceftazidime-Avibactam.

Carbapenem-hydrolyzing beta-lactamase KPC

Carbapenem-hydrolyzing beta-lactamase KPC-1

ALTNLVAEPFAKLEQDFGGSIGVYAMDTGSGATVSYRAEERFPLCSSFKGFLAAAVLARSQQQAGLLDTPIRYGKNALVP
WSPISEKYLTTGMTVAELSAAAVQYSDNAAANLLLKELGGPAGLTAFMRSIGDTTFRLDRWELELNSAIPGDARNTSSPR
AVTESLQKLTLGSALAAPQRQQFVDWLKGNTTGNHRIRAAVPADWAVGDKTGTCGVYGTANDYAVVWPTGRAPIVLAVYT
RAPNKDDKHSEAVIAAAARLALEGLG

20% PEG 6000, 100 mM citrate pH 4.0, and 100 mM KSCN, 10 mM CdCl2

National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID)

beta-lactamase, antibiotic resistance, HYDROLASE

ALTNLVAEPFAKLEQDFGGSIGVYAMDTGSGATVSYRAEERFPLCSSFKGFLAAAVLARSQQQAGLLDTPIRYGKNALVP
WSPISEKYLTTGMTVAELSAAAVQYSDNAAANLLLKELGGPAGLTAFMRSIGDTTFRLDRWELELNSAIPGDARDTSSPR
AVTESLQKLTLGSALAAPQRQQFVDWLKGNTTGNHRIRAAVPADWAVGDKTGTCGVYGTANDYAVVWPTGRAPIVLAVYT
RAPNKDDKHSEAVIAAAARLALEGLG