Cellular Retinoic Acid Binding Protein II with Bound Inhibitor 4-[6-({4-[(fluorosulfonyl)oxy]phenyl}ethynyl)-4,4-dimethyl-3,4-dihydroquinolin-1(2H)-yl]-4-oxobutanoic acid

4-[6-({4-[(fluorosulfonyl)oxy]phenyl}ethynyl)-4,4-dimethyl-3,4-dihydroquinolin-1(2H)-yl]-4-oxobutanoic acid

Development of an Enzyme-Inhibitor Reaction Using Cellular Retinoic Acid Binding Protein II for One-Pot Megamolecule Assembly.

Cellular retinoic acid-binding protein 2

Cellular retinoic acid-binding protein II,CRABP-II

MHHHHHHENLYFQGPNFSGNWKIIRSENFEELLKVLGVNVMLRKIAVAAASKPAVEIKQEGDTFYIKTSTTVRTTEINFK
VGEEFEEQTVDGRPCKSLVKWESENKMVCEQKLLKGEGPKTSWTRELTNDGELILTMTADDVVCTRVYVRE

Escherichia coli 'BL21-Gold(DE3)pLysS AG'

Long thin needles growing in clusters, which had to be mechanically separated for data collection.

National Science Foundation (NSF, United States)

Human Cellular Retinoic Acid Binding Protein II (CRABPII) with bound synthetic retinoid DC271

Hydrogens have been added in their riding positions

Inhibitor complex, SIGNALING PROTEIN-INHIBITOR complex

PNFSGNWKIIRSENFEELLKVLGVNVMLRKIAVAAASKPAVEIKQEGDTFYIKTSTTVRTTEINFKVGEEFEEQTVDGRP
CKSLVKWESENKMVCEQKLLKGEGPKTSWTRELTNDGELILTMTADDVVCTRVYVRE