Structure of PfCSP peptide 21 with antibody iGL-CIS43.D3

Vaccination in a humanized mouse model elicits highly protective PfCSP-targeting anti-malarial antibodies.

QVHLVQSGAEVKKPGASVKVSCKASGYTFTRYAIHWVRQAPGQRLEWMGWIKGGNGNTRYSQKFQDRVTITRDTSASTAY
MELSSLRSEDTAVYYCALLTVITPDDAFDIWGQGTMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTV
SWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDK

DIVMTQSPDSLAVSLGERATINCKSSQNIFFSSNNKNYLAWYQQKPGQPPKLLFYWASTRESGVPDRFSGSGSGTDFTLT
ISSLQAEDVAVYYCHQYYSSPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNAL
QSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC

0.2 M Zn acetate, 0.1 M MES, 17.53% w/v PEG 8000

National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID)

Antibody, Plasmodium falciparum, IMMUNE SYSTEM