Structure of the Phospholipase C gamma 1 tSH2 domain in complex with a phosphorylated KSHV pK15 peptide

Recruitment of phospholipase C gamma 1 to the non-structural membrane protein pK15 of Kaposi Sarcoma-associated herpesvirus promotes its Src-dependent phosphorylation.

PETRA III, EMBL c/o DESY BEAMLINE P13 (MX1)

Isoform 2 of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

PLC-148,Phosphoinositide phospholipase C-gamma-1,Phospholipase C-II,PLC-II,Phospholipase C-gamma-1,PLC-gamma-1

HSNEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFWRNGKVQHCRIHSRQDAGTPKFFLT
DNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQTNAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPNSYAI
SFRAEGKIKHCRVQQEGQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYG

30% PEG 4000, 0.1M TrisHCl pH 8.5, 0.2M sodium acetate

HHV-8, Kaposi's sarcoma-associated herpesvirus

KSHV, complex, phosphorylation, VIRAL PROTEIN