Structure of the extracellular WNT-binding module in Drosophila Ror2/Nrk

N-acetyl-beta-D-glucosamine; 2-acetamido-2-deoxy-beta-D-glucose; 2-acetamido-2-deoxy-D-glucose; 2-acetamido-2-deoxy-glucose; N-ACETYL-D-GLUCOSAMINE

ROR and RYK extracellular region structures suggest that receptor tyrosine kinases have distinct WNT-recognition modes.

Tyrosine-protein kinase transmembrane receptor Ror2
Extracellular domain, UNP residues 42-321

dRor2,Neurospecific receptor tyrosine kinase

NSLNAIEEPVTRRHHQRHHEREREENGYCAPYSGKVCKEYLTGQVWYSLEDPTGGWKNEQVTTALWDELISDLTGLCREA
AEKMLCAYAFPNCHMEGGRAVKAPLCFEDCQATHLQFCYNDWVLIEEKKERNMFIKSRGHFRLPNCSSLPHYNASMRRPN
CSYIGLTELKESEVSYDCRNGNGRFYMGTMNVSKSGIPCQRWDTQYPHKHFQPPLVFHQLLEGENYCRNAGGEEPHPWCY
TVDESVRWQHCDIPMCPDYVDPNAVDLNTPIKMEKFFTPS

3 mg/ml protein, 50 mM Bis-Tris propane (pH 5.0), 21% PEG 3350

National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)

WNT signaling, receptor tyrosine kinases, acylation, growth factor signaling, co-receptor, pseudokinases, ligand, receptor, cancer, SIGNALING PROTEIN