Crystal structure of synthetic nanobody (Sb45) complexes with SARS-CoV-2 receptor binding domain

2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.

Structures of synthetic nanobody-SARS-CoV-2 receptor-binding domain complexes reveal distinct sites of interaction.

Synthetic nanobody-SARS-CoV-2 receptor-binding domain structures identify distinct epitopes.

TNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAP
GQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPL
QSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPK

QVQLVESGGGLVQAGGSLRLSCAASGFPVYRDRMAWYRQAPGKEREWVAAIYSAGQQTRYADSVKGRFTISRDNAKNTVY
LQMNSLKPEDTAVYYCNVKDVGHHYEYYDYWGQGTQVTVSA

Severe acute respiratory syndrome coronavirus 2

SARS-CoV-2, Spike Protein, RBD, Antibody, Nanobody, Sybody, VIRAL PROTEIN, epitopes, neutralization