X-ray structure of Lfa-1 I domain in complex with Lovastatin collected at 273 K

Divergent conformational dynamics controls allosteric ligand accessibility across evolutionarily related I-domain-containing integrins

CD11 antigen-like family member A,Leukocyte adhesion glycoprotein LFA-1 alpha chain,LFA-1A,Leukocyte function-associated molecule 1 alpha chain

GSGNVDLVFLFDGSMSLQPDEFQKILDFMKDVMKKLSNTSYQFAAVQFSTSYKTEFDFSDYVKRKDPDALLKHVKHMLLL
TNTFGAINYVATEVFREELGARPDATKVLIIITDGEATDSGNIDAAKDIIRYIIGIGKHFQTKESQETLHKFASKPASEF
VKILDTFEKLKDLFTELQKKIYVI

National Science Foundation (NSF, United States)

National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)

7KC3 contains the same protein without ligand

7KC5 contains the same protein with BMS-688521

GNVDLVFLFDGSMSLQPDEFQKILDFMKDVMKKLSNTSYQFAAVQFSTSYKTEFDFSDYVKRKDPDALLKHVKHMLLLTN
TFGAINYVATEVFREELGARPDATKVLIIITDGEATDSGNIDAAKDIIRYIIGIGKHFQTKESQETLHKFASKPASEFVK
ILDTFEKLKDLFTELQKKIYVI