Crystal structure of ICOS in complex with antibody STIM003 and anti-kappa VHH domain

2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.

N-acetyl-beta-D-glucosamine; 2-acetamido-2-deoxy-beta-D-glucose; 2-acetamido-2-deoxy-D-glucose; 2-acetamido-2-deoxy-glucose; N-ACETYL-D-GLUCOSAMINE

Structural characterization of the ICOS/ICOS-L immune complex reveals high molecular mimicry by therapeutic antibodies.

Activation-inducible lymphocyte immunomediatory molecule

(UNK)VQL(UNK)(UNK)SGGG(UNK)VQ(UNK)G(UNK)SL(UNK)LSC(UNK)A(UNK)(UNK)(UNK)(UNK)
(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)W(UNK)RQ(UNK)PG(UNK)(UNK)RE(UNK)V(UNK)(UNK)
(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)DS(UNK)(UNK)GRFT(UNK)S
(UNK)D(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)LQ(UNK)(UNK)(UNK)L(UNK)(UNK)(UNK)D(UNK)
A(UNK)YYC(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)W
G(UNK)GT(UNK)VTVSS

XVQLXXSGGGXVQXGXSLXLSCXAXXXXXXXXXXXWXRQXPGXXREXVXXXXXXXXXXXXXDSXXGRFTXSXDXXXXXXX
LQXXXLXXXDXAXYYCXXXXXXXXXXXXXXWGXGTXVTVSS

EVQLVESGGGVVRPGGSLRLSCVASGVTFDDYGMSWVRQAPGKGLEWVSGINWNGGDTDYSDSVKGRFTISRDNAKNSLY
LQMNSLRAEDTALYYCARDFYGSGSYYHVPFDYWGQGILVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEP
VTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC

EIVLTQSPGTLSLSPGERATLSCRASQSVSRSYLAWYQQKRGQAPRLLIYGASSRATGIPDRFSGDGSGTDFTLSISRLE
PEDFAVYYCHQYDMSPFTFGPGTKVDIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNS
QESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC

TGEIQGSANYEMFIFHNGGVQILCKYPDIVQQFKMQLLKGGQILCDLTKTKGSGNTVSIKSLKFCHSQLSNNSVSFFLYN
LDHSHANYYFCNLSIFDPPPFKVTLTGGYLHIYESQLAAQGTENLYFQ

Escherichia coli-Pichia pastoris shuttle vector pPpARG4

0.2 M di-sodium hydrogen phosphate and 20% (w/v) polyethylene glycol 3350

Canadian Institutes of Health Research (CIHR)

Immune checkpoint, immune system, glycoprotein, receptor, T-cell, antibody

TGEINGSANYEMFIFHNGGVQILCKYPDIVQQFKMQLLKGGQILCDLTKTKGSGNTVSIKSLKFCHSQLSNNSVSFFLYN
LDHSHANYYFCNLSIFDPPPFKVTLTGGYLHIYESQLCCQ