Crystal Structure of Aspergillus terreus Glutamate Dehydrogenase (AtGDH) Complexed With Succinate and ADP-ribose

[(2R,3R,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3-HYDROXY-4-(PHOSPHONOOXY)TETRAHYDROFURAN-2-YL]METHYL [(2R,3S,4R,5R)-3,4,5-TRIHYDROXYTETRAHYDROFURAN-2-YL]METHYL DIHYDROGEN DIPHOSPHATE

Molecular insights into the inhibition of glutamate dehydrogenase by the dicarboxylic acid metabolites.

MSNLPVEPEFEQAYKELASTLENSTLFQKNPEYRKALAVVSVPERVIQFRVVWENDKGEVQVNRGFRVQFNSALGPYKGG
LRFHPSVNLSILKFLGFEQIFKNALTGLNMGGGKGGSDFDPKGKSDSEIRRFCVAFMTELCRHIGADTDVPAGDIGVTGR
EIGYLFGQYRKLRNSWEGVLTGKGGSWGGSLIRPEATGYGVVYYVEHMIAHATNGAESFAGKRVAISGSGNVAQYAALKV
IELGGRVVSLSDSQGSLIVKDTAKDSFTPAEIDAIAALKVDRKQIAELVTDAAFADKFTYLPGQRPWVHVGAVDVALPSA
TQNEVSGEEAQALIAAGCKFIAEGSNMGCTQAAIDAFEAHREANKGAAAIWYAPGKAANAGGVAVSGLEMAQNSARLSWT
AEEVDARLKDIMKSCFQNGLDTAKEYATPADGILPSLVTGSNIAGFTKVAAAMKDQGDWW

Department of Biotechnology (DBT, India)

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS

Glutamate dehydrogenase, allostery, Aspergillus, enzyme mechanism, OXIDOREDUCTASE