Crystal structure of PDE8A catalytic domain in complex with 3a

Rational Design of 2-Chloroadenine Derivatives as Highly Selective Phosphodiesterase 8A Inhibitors.

High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A

DDVPPRIARAMENEEYWDFDIFELEAATHNRPLIYLGLKMFARFGICEFLHCSESTLRSWLQIIEANYHSSNPYHNSTHS
ADVLHATAYFLSKERIKETLDPIDEVAALIAATIHDVDHPGRTNSFLCNAGSELAILYNDTAVLESHHAALAFQLTTGDD
KCNIFKNMERNDYRTLRQGIIDMVLATEMTKHFEHVNKFVNSINKPLATLEENGETDKNQEVINTMLRTPENRTLIKRML
IKCADVSNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPVFDRNTCSIPKSQISFIDYFITDMFDAWDAFVDLPD
LMQHLDNNFKYWKGLDEM

100mM Cacodylate Sodium pH 6.5, 15% Isopropanol, 30% Ethylene Glycol, 11% PEG3350

National Natural Science Foundation of China (NSFC)

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS

cAMP-specific, HYDROLASE, Selective PDE8A inhibitor