Crystal structure of the SARS-CoV-2 main protease in complex with Z-VAD(OMe)-FMK

(2S)-2-azanyl-4-methoxy-4-oxidanylidene-butanoic acid

main protease,3CL-PRO,3CLp,Mpro,Non-structural protein 5,nsp5,SARS coronavirus main proteinase

SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGH
SMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFC
YMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYE
PLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQ

Severe acute respiratory syndrome coronavirus 2

National Natural Science Foundation of China (NSFC)

the same protein with the different inhibitor

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS U VALUES : REFINED INDIVIDUALLY

Coronavirus, Protease, Inhibitor, Complex, Viral Protein, HYDROLASE-HYDROLASE INHIBITOR complex

binding site for residues FL6 D 4 and CF0 D 5