Crystal structure of SARS-CoV-2 main protease treated with ebselen derivative of MR6-31-2

Inhibition mechanism of SARS-CoV-2 main protease by ebselen and its derivatives.

SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGH
SMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFC
YMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYE
PLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQ

Severe acute respiratory syndrome coronavirus 2

200mM ammonium chloride, 5%glycerol and 20% polyethylene glycol mw. 3350

Biotechnology and Biological Sciences Research Council (BBSRC)

Hydrogens have been added in their riding positions

SARS-CoV-2, main protease, COVID19, ebselen, VIRAL PROTEIN