NMR2 structure of TRIM24-BD in complex with a precursor of IACS-9571
NMR Molecular Replacement Provides New Insights into Binding Modes to Bromodomains of BRD4 and TRIM24.
ASP A 955 HAS WRONG CHIRALITY AT ATOM CA
ASP A 983 HAS WRONG CHIRALITY AT ATOM CA
Transcription intermediary factor 1-alpha
TIF1-alpha,E3 ubiquitin-protein ligase TRIM24,RING finger protein 82,RING-type E3 ubiquitin transferase TIF1-alpha,Tripartite motif-containing protein 24
TPIDKRKCERLLLFLYCHEMSLAFQDPVPLTVPDYYKIIKNPMDLSTIKKRLQEDYSMYSKPEDFVADFRLIFQNCAEFN EPDSEVANAGIKLENYFEELLKNLYP
1.1 mM [U-13C; U-15N] TRIM24-BD, 50 mM [U-2H] HEPES, 100 mM sodium chloride, 1 mM TCEP, 10 % [U-2H] D2O, 1.1 mM N-{6-[3-(4-Aminobutoxy)-5-propoxyphenoxy]-1,3-dimethyl-2-oxo-2,3-dihydro-1H-1,3-benzodiazol-5-yl}-3,4-dimethoxybenzene-1-sulfonamide, 90% H2O/10% D2O
50 mM [U-2H] HEPES, 100 mM sodium chloride, 1 mM TCEP, 10 % [U-2H] D2O, 1.1 % N-{6-[3-(4-Aminobutoxy)-5-propoxyphenoxy]-1,3-dimethyl-2-oxo-2,3-dihydro-1H-1,3-benzodiazol-5-yl}-3,4-dimethoxybenzene-1-sulfonamide, 90% H2O/10% D2O
TRIM24, bromodomain, IACS-9571, NMR2, ONCOPROTEIN