Plasmoodium vivax phosphoglycerate kinase bound to nitrofuran inhibitor from PEGSmear at pH 6.5

Phosphoglycerate Kinase as a potential target for antimalarial therapy

SLGNKLSITDVKAIQGKKVLVRVDFNVPIENGVIKDTNRITATLPTIHHLKKEGAAKIILISHCGRPDGTKNLKYTLKPV
AETLGTLLGEEVLFLSDCVGEEVAAQINQAKDNSVILLENLRFHVEEEGKGVDAAGNKIKASKEDMEKFQNELTKLGDVF
INDAFGTAHRAHSSMVGIKMNVKASGFLMKKELEYFSKALENPQRPLLAILGGAKVSDKIQLIKNLLDKVDKMIIGGGMA
YTFKYVLNNMKIGDSLFDEAGSKIVNEIMEKAKAKNVEIYLPVDFKVADKFDNNANTKVVTDEEGIEDKWMGLDAGPKSI
ENYKDVILSSKTIIWNGPQGVFEMPNFAKGSIECLNLVIEATKKGAISIVGGGDTASLVEQQQKKNEISHVSTGGGASLE
LLEGKELPGVVALSSK

phosphoglycerate kinase, metabolic enzyme, kinase, BIOSYNTHETIC PROTEIN

LGNKLSITDVKAIQGKKVLVRVDFNVPIENGVIKDTNRITATLPTIHHLKKEGAAKIILISHCGRPDGTKNLKYTLKPVA
ETLGTLLGEEVLFLSDCVGEEVAAQINQAKDNSVILLENLRFHVEEEGKGVDAAGNKIKASKEDMEKFQNELTKLGDVFI
NDAFGTAHRAHSSMVGIKMNVKASGFLMKKELEYFSKALENPQRPLLAILGGAKVSDKIQLIKNLLDKVDKMIIGGGMAY
TFKYVLNNMKIGDSLFDEAGSKIVNEIMEKAKAKNVEIYLPVDFKVADKFDNNANTKVVTDEEGIEDKWMGLDAGPKSIE
NYKDVILSSKTIIWNGPQGVFEMPNFAKGSIECLNLVIEATKKGAISIVGGGDTASLVEQQQKKNEISHVSTGGGASLEL
LEGKELPGVVALSSK