Crystal structure of human PPARgamma ligand binding domain in complex with GW1929

(2~{S})-3-[4-[2-[methyl(pyridin-2-yl)amino]ethoxy]phenyl]-2-[[2-(phenylcarbonyl)phenyl]amino]propanoic acid

Structural mechanism underlying ligand binding and activation of PPAR gamma.

Peroxisome proliferator-activated receptor gamma

PPAR-gamma,Nuclear receptor subfamily 1 group C member 3

QLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIF
QGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGD
FMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDL
RQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY

National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Disease (NIH/NIDDK)

Nuclear receptors, TZDs, Drug design, Therapeutic targets, TRANSCRIPTION