CryoEM structure of HIV-1 cleaved synaptic complex (CSC) intasome

A Peptide Derived from Lens Epithelium-Derived Growth Factor Stimulates HIV-1 DNA Integration and Facilitates Intasome Structural Studies.

GSHMPKRGRPAATEVKIPKPRGRPPLPAGTNSKGPPDFSSDEEREPTPVLGSGAAAAGQSRAAVGRKATKKTDGGGFLDG
IDKAQEEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGIWQLDCTHLEGKVILVAVHVASGYI
EAEVIPAETGQETAYFLLKLAGRWPVKTVHTDNGSNFTSTTVKAACWWAGIKQEFGIPYNPQSQGVIESMNKELKKIIGQ
VRDQAEHLKTAVQMAVFIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPVWKGPAKLLWK
GEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED

(DA)(DC)(DT)(DG)(DC)(DT)(DA)(DG)(DA)(DG)(DA)(DT)(DT)(DT)(DT)(DC)(DC)(DC)(DG)(DC)
(DC)(DC)(DA)(DC)(DG)(DC)(DT)

(DA)(DG)(DC)(DG)(DT)(DG)(DG)(DG)(DC)(DG)(DG)(DG)(DA)(DA)(DA)(DA)(DT)(DC)(DT)(DC)
(DT)(DA)(DG)(DC)(DA)

National Institutes of Health/National Human Genome Research Institute (NIH/NHGRI)

National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Disease (NIH/NIDDK)

site-specific recombination, retrovirus, integrase, integration, nucleoprotein complex, TRANSFERASE-TRANSFERASE INHIBITOR-DNA complex

FLDGIDKAQEEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGIWQLDCTHLEGKVILVAVHVA
SGYIEAEVIPAETGQETAYFLLKLAGRWPVKTVHTDNGSNFTSTTVKAACWWAGIKQEFGIPYNPQSQGVIESMNKELKK
IIGQVRDQAEHLKTAVQMAVFIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPVWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED