Crystal Structure of the carboxyltransferase subunit of ACC (AccD6) in complex with inhibitor Phenyl-Cyclodiaone from Mycobacterium tuberculosis

TB Structural Genomics Consortium (TBSGC)

Novel herbicidal derivatives that inhibit carboxyltransferase subunit of the acetyl-CoA carboxylase in Mycobacterium tuberculosis

Probable propionyl-CoA carboxylase beta chain 6

PCCase,Propanoyl-CoA:carbon dioxide ligase

MTIMAPEAVGESLDPRDPLLRLSNFFDDGSVELLHERDRSGVLAAAGTVNGVRTIAFCTDGTVMGGAMGVEGCTHIVNAY
DTAIEDQSPIVGIWHSGGARLAEGVRALHAVGQVFEAMIRASGYIPQISVVVGFAAGGAAYGPALTDVVVMAPESRVFVT
GPDVVRSVTGEDVDMASLGGPETHHKKSGVCHIVADDELDAYDRGRRLVGLFCQQGHFDRSKAEAGDTDIHALLPESSRR
AYDVRPIVTAILDADTPFDEFQANWAPSMVVGLGRLSGRTVGVLANNPLRLGGCLNSESAEKAARFVRLCDAFGIPLVVV
VDVPGYLPGVDQEWGGVVRRGAKLLHAFGECTVPRVTLVTRKTYGGAYIAMNSRSLNATKVFAWPDAEVAVMGAKAAVGI
LHKKKLAAAPEHEREALHDQLAAEHERIAGGVDSALDIGVVDEKIDPAHTRSKLTEALAQAPARRGRHKNIPL

Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

0.2 M Li2SO4, 0.1 M Tris pH 7, 1 M potassium sodium tartarate

National Institutes of Health/National Human Genome Research Institute (NIH/NHGRI)

6PRW contains the same protein complexed with its analog

TRANSFERASE INHIBITOR ACCD6, CARBOXYLTRANSFERASE BETA-SUBUNIT OF ACYL-COACARBOXYLASE, Structural Genomics, TB Structural Genomics Consortium, TBSGC, TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR complex