Structure of Ku80 von Willebrand domain complexed with APLF Ku Binding Motif

2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.

Ligand binding characteristics of the Ku80 von Willebrand domain.

X-ray repair cross-complementing protein 5
C190S, deletion loop (E171 through R188)

MHHHHHHMARAAKSAVVLCMDVGLAMSHSNQGKESPFEQAKKVMMLFLQRQVFAESKDEIAVVLYGTDTTDNALAREDQY
ENISVHRHLMLPDFDLLEQIENVVEPGSVQADFLDALIVSMDLLQKETLGKKYTRLHIAVFSDLSSPFSVDQLEVIIANL
KKAEITLQFFLPFSVDEGSGPGKGLSDQQKEGIEMVRKIMFSLDGEEGLSEVFTFRDSLERLSIFKKIERR

National Institutes of Health/National Institute of Environmental Health Sciences (NIH/NIEHS)

6TYU contains the same protein complexed with MRI

6TYV contains the same protein complexed with WRN

6TYT contains the mutant protein complexed with APLF and XLF

6TYW contains the mutant protein complexed with APLF

6TYX contains the mutant protein complexed with XLF

chain 'A' and (resid 6 through 28 )

chain 'A' and (resid 29 through 46 )

chain 'A' and (resid 47 through 80 )

chain 'A' and (resid 81 through 96 )

chain 'A' and (resid 97 through 134 )

chain 'A' and (resid 135 through 164 )

chain 'A' and (resid 165 through 197 )

chain 'A' and (resid 198 through 235 )

chain 'B' and (resid 181 through 187 )

chain 'B' and (resid 188 through 192 )

Ku80 von Willebrand factor A domain, Fluorine-19 NMR, Ku binding motif, Conditional binding site, DNA BINDING PROTEIN

MARAAKSAVVLCMDVGLAMSHSNQGKESPFEQAKKVMMLFLQRQVFAESKDEIAVVLYGTDTTDNALAREDQYENISVHR
HLMLPDFDLLEQIENVVEPGSVQADFLDALIVSMDLLQKETLGKKYTRLHIAVFSDLSSPFSVDQLEVIIANLKKAEITL
QFFLPFSVDEEEFGGSSNNRGNAGSSDRGCGPGKGLSDQQKEGIEMVRKIMFSLDGEEGLSEVFTFRDSLERLSIFKKIE
RR