A4V MUTANT OF HUMAN SOD1 WITH EBSELEN DERIVATIVE 4

Ebselen as template for stabilization of A4V mutant dimer for motor neuron disease therapy.

MATKVVCVLKGDGPVQGIINFEQKESNGPVKVWGSIKGLTEGLHGFHVHEFGDNTAGCTSAGPHFNPLSRKHGGPKDEER
HVGDLGNVTADKDGVADVSIEDSVISLSGDHCIIGRTLVVHEKADDLGKGGNEESTKTGNAGSRLACGVIGIAQ

100mM Tris-HCl pH 7.8, 2.6 M ammonium sulphate

A4V SOD1 mutant, ebselen, ebselen derivatives, OXIDOREDUCTASE

MATKAVCVLKGDGPVQGIINFEQKESNGPVKVWGSIKGLTEGLHGFHVHEFGDNTAGCTSAGPHFNPLSRKHGGPKDEER
HVGDLGNVTADKDGVADVSIEDSVISLSGDHCIIGRTLVVHEKADDLGKGGNEESTKTGNAGSRLACGVIGIAQ

binding site for Di-peptide LQW B 201 and CYS B 111

binding site for Di-peptide LQW C 201 and CYS C 111

binding site for Di-peptide LQW D 201 and CYS D 111

binding site for Di-peptide LQW E 201 and CYS E 111

binding site for Di-peptide LQW F 201 and CYS F 111

binding site for Di-peptide LQW G 201 and CYS G 111

binding site for Di-peptide LQW H 201 and CYS H 111

binding site for Di-peptide LQW I 201 and CYS I 111

binding site for Di-peptide LQW K 201 and CYS K 111

binding site for Di-peptide LQW L 201 and CYS L 111