Structure of HPV49 E6 protein in complex with MAML1 LxxLL motif

Cellular target recognition by HPV18 and HPV49 oncoproteins

Residues 1-362: MALTOSE-BINDING PERIPLASMIC PROTEIN, Uniprot P0AEX9, Natural source: Escherichi coli. Residues 1001-1136: HPV49 E6 Protein, Uniprot P36813, Natural source: Human papilloma virus type 49. Residues 2002-2015: MAML1, Uniprot Q92585, Natural source: Homo sapiens.,Residues 1-362: MALTOSE-BINDING PERIPLASMIC PROTEIN, Uniprot P0AEX9, Natural source: Escherichi coli. Residues 1001-1136: HPV49 E6 Protein, Uniprot P36813, Natural source: Human papilloma virus type 49. Residues 2002-2015: MAML1, Uniprot Q92585, Natural source: Homo sapiens.,Residues 1-362: MALTOSE-BINDING PERIPLASMIC PROTEIN, Uniprot P0AEX9, Natural source: Escherichi coli. Residues 1001-1136: HPV49 E6 Protein, Uniprot P36813, Natural source: Human papilloma virus type 49. Residues 2002-2015: MAML1, Uniprot Q92585, Natural source: Homo sapiens.,Residues 1-362: MALTOSE-BINDING PERIPLASMIC PROTEIN, Uniprot P0AEX9, Natural source: Escherichi coli. Residues 1001-1136: HPV49 E6 Protein, Uniprot P36813, Natural source: Human papilloma virus type 49. Residues 2002-2015: MAML1, Uniprot Q92585, Natural source: Homo sapiens.,Residues 1-362: MALTOSE-BINDING PERIPLASMIC PROTEIN, Uniprot P0AEX9, Natural source: Escherichi coli. Residues 1001-1136: HPV49 E6 Protein, Uniprot P36813, Natural source: Human papilloma virus type 49. Residues 2002-2015: MAML1, Uniprot Q92585, Natural source: Homo sapiens.,Residues 1-362: MALTOSE-BINDING PERIPLASMIC PROTEIN, Uniprot P0AEX9, Natural source: Escherichi coli. Residues 1001-1136: HPV49 E6 Protein, Uniprot P36813, Natural source: Human papilloma virus type 49. Residues 2002-2015: MAML1, Uniprot Q92585, Natural source: Homo sapiens.,Residues 1-362: MALTOSE-BINDING PERIPLASMIC PROTEIN, Uniprot P0AEX9, Natural source: Escherichi coli. Residues 1001-1136: HPV49 E6 Protein, Uniprot P36813, Natural source: Human papilloma virus type 49. Residues 2002-2015: MAML1, Uniprot Q92585, Natural source: Homo sapiens.,Residues 1-362: MALTOSE-BINDING PERIPLASMIC PROTEIN, Uniprot P0AEX9, Natural source: Escherichi coli. Residues 1001-1136: HPV49 E6 Protein, Uniprot P36813, Natural source: Human papilloma virus type 49. Residues 2002-2015: MAML1, Uniprot Q92585, Natural source: Homo sapiens.,Residues 1-362: MALTOSE-BINDING PERIPLASMIC PROTEIN, Uniprot P0AEX9, Natural source: Escherichi coli. Residues 1001-1136: HPV49 E6 Protein, Uniprot P36813, Natural source: Human papilloma virus type 49. Residues 2002-2015: MAML1, Uniprot Q92585, Natural source: Homo sapiens.
Maltose/maltodextrin-binding periplasmic protein,Protein E6,Mastermind-like protein 1

MMBP,Maltodextrin-binding protein,Maltose-binding protein,MBP,Mam-1

MKIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQVAATGDGPDIIFWAHDRFGGYAQSGLLAEI
TPAAAFQDKLYPFTWDAVRYNGKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFNLQEPYFTWP
LIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLIKNKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSA
VNYGVTVLPTFKGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAVALKSYEEELAKDPRIAA
TMENAQKGEIMPNIPQMSAFWYAVRTAVINAASGRQTVDAALAAAQTNAAAMARPVKVAELAHHLNIPIWEVLLPCNFCT
GFLTYQELLEFDYKDFNLLWKDGFVFGCCAACAYRSAYHEFTNYHQEIVVGIEIEGRAAANIAEIVVRCLICLKRLDLLE
KLDICAQHREFHRVRNRWKGVCRHCRVIEGSGSGSGSGSGSAAAEEWMSDLDDLLGSQ

MBP density is poor and model was improved.

equipe labellisee 2015 and fellowship AB

National Institutes of Health/National Cancer Institute (NIH/NCI)

Foundation for Medical Research (France)

chain 'A' and (resid 1001 through 1136 )

chain 'A' and (resid 1998 through 2015 )

HPV49 E6 protein, MAML1, LxxLL motif, VIRAL PROTEIN

AKIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQVAATGDGPDIIFWAHDRFGGYAQSGLLAEI
TPDKAFQDKLYPFTWDAVRYNGKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFNLQEPYFTWP
LIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLIKNKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSK
VNYGVTVLPTFKGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAVALKSYEEELAKDPRIAA
TMENAQKGEIMPNIPQMSAFWYAVRTAVINAASGRQTVDEALKDAQT

MARPVKVCELAHHLNIPIWEVLLPCNFCTGFLTYQELLEFDYKDFNLLWKDGFVFGCCAACAYRSAYHEFTNYHQEIVVG
IEIEGRAAANIAEIVVRCLICLKRLDLLEKLDICAQHREFHRVRNRWKGVCRHCRVIE