Influenza A Polymerase Heterotrimer Human H3N2 Northern Territory 1968

2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.

1-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.

Structures of influenza A virus RNA polymerase offer insight into viral genome replication.

RNA-directed RNA polymerase catalytic subunit

Polymerase basic protein 1,PB1,RNA-directed RNA polymerase subunit P1

MEDFVRQCFNPMIVELAEKAMKEYGEDLKIETNKFAAICTHLEVCFMYSDFHFINEQGESIVVELDDPNALLKHRFEIIE
GRDRTMAWTVVNSICNTTGAEKPKFLPDLYDYKENRFIEIGVTRREVHIYYLEKANKIKSENTHIHIFSFTGEEMATKAD
YTLDEESRARIKTRLFTIRQEMANRGLWDSFRQSERGEETIEERFEITGTMRRLADQSLPPNFSCLENFRAYVDGFEPNG
YIEGKLSQMSKEVNAKIEPFLKTTPRPIRLPDGPPCFQRSKFLLMDALKLSIEDPSHEGEGIPLYDAIKCMRTFFGWKEP
YIVKPHEKGINPNYLLSWKQVLAELQDIENEEKIPRTKNMKKTSQLKWALGENMAPEKVDFDNCRDVSDLKQYDSDEPEL
RSLSSWIQNEFNKACELTDSTWIELDEIGEDVAPIEYIASMRRNYFTAEVSHCRATEYIMKGVYINTALLNASCAAMDDF
QLIPMISKCRTKEGRRKTNLYGFIIKGRSHLRNDTDVVNFVSMEFSLTDPRLEPHKWEKYCVLEIGDMLLRSAIGQMSRP
MFLYVRTNGTSKIKMKWGMEMRRCLLQSLQQIESMIEAESSVKEKDMTKEFFENKSETWPIGESPKGVEDGSIGKVCRTL
LAKSVFNSLYASPQLEGFSAESRKLLLVVQALRDNLEPGTFDLEGLYEAIEECLINDPWVLLNASWFNSFLTHALR

MDVNPTLLFLKVPAQNAISTTFPYTGDPPYSHGTGTGYTMDTVNRTHQYSEKGKWTTNTETGAPQLNPIDGPLPEDNEPS
GYAQTDCVLEAMAFLEESHPGIFENSCLETMEVVQQTRVDRLTQGRQTYDWTLNRNQPAATALANTIEVFRSNGLTANES
GRLIDFLKDVMESMDKEEMEITTHFQRKRRVRDNMTKKMVTQRTIGKKKQRVNKRSYLIRALTLNTMTKDAERGKLKRRA
IATPGMQIRGFVYFVETLARSICEKLEQSGLPVGGNEKKAKLANVVRKMMTNSQDTELSFTITGDNTKWNENQNPRMFLA
MITYITKNQPEWFRNVLSIAPIMFSNKMARLGKGYMFESKSMKLRTQIPAEMLASIDLKYFNESTRKKIEKIRPLLIDGT
ASLSPGMMMGMFNMLSTVLGVSILNLGQKRYTKTTYWWDGLQSSDDFALIVNAPNHEGIQAGVDRFYRTCKLVGINMSKK
KSYINRTGTFEFTSFFYRYGFVANFSMELPSFGVSGINESADMSIGVTVIKNNMINNDLGPATAQMALQLFIKDYRYTYR
CHRGDTQIQTRRSFELKKLWEQTRSKAGLLVSDGGPNLYNIRNLHIPEVCLKWELMDEDYQGRLCNPLNPFVSHKEIESV
NNAVVMPAHGPAKSMEYDAVATTHSWIPKRNRSILNTSQRGILEDEQMYQKCCNLFEKFFPSSSYRRPVGISSMVEAMVS
RARIDARIDFESGRIKKEEFAEIMKICSTIEELRRQK

MERIKELRNLMSQSRTREILTKTTVDHMAIIKKYTSGRQEKNPSLRMKWMMAMKYPITADKRITEMVPERNEQGQTLWSK
MSDAGSDRVMVSPLAVTWWNRNGPMTSTVHYPKVYKTYFEKVERLKHGTFGPVHFRNQVKIRRRVDINPGHADLSAKEAQ
DVIMEVVFPNEVGARILTSESQLTITKEKKEELQDCKISPLMVAYMLERELVRKTRFLPVAGGTSSVYIEVLHLTQGTCW
EQMYTPGGEVRNDDVDQSLIIAARNIVRRAAVSADPLASLLEMCHSTQIGGTRMVDILRQNPTEEQAVDICKAAMGLRIS
SSFSFGGFTFKRTSGSSIKREEELLTGNLQTLKIRVHDGYEEFTMVGKRATAILRKATRRLVQLIVSGRDEQSVAEAIIV
AMVFSQEDCMIKAVRGDLNFVNRANQRLNPMHQLLRHFQKDAKVLFQNWGIEHIDNVMGMIGVLPDMTPSTEMSMRGIRV
SKMGVDEYSSTERVVVSIDRFLRVRDQRGNVLLSPEEVSETQGTEKLTITYSSSMMWEINGPESVLVNTYQWIIRNWETV
KIQWSQNPTMLYNKMEFEPFQSLVPKAIRGQYSGFVRTLFQQMRDVLGTFDTTQIIKLLPFAAAPPKQSRMQFSSLTVNV
RGSGMRILVRGNSPAFNYNKTTKRLTILGKDAGTLIEDPDEGTSGVESAVLRGFLILGKEDRRYGPALSINELSNLAKGE
KANVLIGQGDVVLVMKRKRDSSILTDSQTATKRIRMAINENLYFQ

Influenza A virus (A/Northern Territory/60/1968(H3N2))

Influenza A virus (strain A/Northern Territory/60/1968 H3N2)

Medical Research Council (United Kingdom)

chain 'A' and (resid 1 through 184 )
chain 'A' and (resid 185 through 405 )
chain 'A' and (resid 406 through 716 )
chain 'B' and (resid 1 through 56 )
chain 'B' and (resid 57 through 359 )
chain 'B' and (resid 360 through 518 )
chain 'B' and (resid 519 through 617 )
chain 'B' and (resid 618 through 713 )
chain 'B' and (resid 714 through 756 )
chain 'C' and (resid 1 through 140 )
chain 'C' and (resid 141 through 220 )
chain 'C' and (resid 221 through 422 )
chain 'C' and (resid 423 through 565 )
chain 'C' and (resid 566 through 667 )
chain 'C' and (resid 668 through 756 )
chain 'D' and (resid 1 through 184 )
chain 'D' and (resid 185 through 288 )
chain 'D' and (resid 289 through 526 )
chain 'D' and (resid 527 through 714 )
chain 'E' and (resid 1 through 84 )
chain 'E' and (resid 85 through 152 )
chain 'E' and (resid 153 through 248 )
chain 'E' and (resid 249 through 325 )
chain 'E' and (resid 326 through 473 )
chain 'E' and (resid 474 through 540 )
chain 'E' and (resid 541 through 593 )
chain 'E' and (resid 594 through 699 )
chain 'E' and (resid 700 through 756 )
chain 'F' and (resid 1 through 220 )
chain 'F' and (resid 221 through 422 )
chain 'F' and (resid 423 through 541 )
chain 'F' and (resid 542 through 704 )
chain 'F' and (resid 705 through 752 )
chain 'G' and (resid 1 through 184 )
chain 'G' and (resid 185 through 288 )
chain 'G' and (resid 289 through 405 )
chain 'G' and (resid 406 through 716 )
chain 'H' and (resid 1 through 84 )
chain 'H' and (resid 85 through 247 )
chain 'H' and (resid 248 through 325 )
chain 'H' and (resid 326 through 382 )
chain 'H' and (resid 383 through 427 )
chain 'H' and (resid 428 through 473 )
chain 'H' and (resid 474 through 518 )
chain 'H' and (resid 519 through 634 )
chain 'H' and (resid 635 through 713 )
chain 'H' and (resid 714 through 756 )
chain 'I' and (resid 1 through 140 )
chain 'I' and (resid 141 through 220 )
chain 'I' and (resid 221 through 328 )
chain 'I' and (resid 329 through 422 )
chain 'I' and (resid 423 through 541 )
chain 'I' and (resid 542 through 705 )
chain 'I' and (resid 706 through 756 )
chain 'J' and (resid 1 through 184 )
chain 'J' and (resid 185 through 405 )
chain 'J' and (resid 406 through 526 )
chain 'J' and (resid 527 through 716 )
chain 'K' and (resid 1 through 84 )
chain 'K' and (resid 85 through 247 )
chain 'K' and (resid 248 through 325 )
chain 'K' and (resid 326 through 518 )
chain 'K' and (resid 519 through 617 )
chain 'K' and (resid 618 through 756 )
chain 'L' and (resid 1 through 255 )
chain 'L' and (resid 256 through 485 )
chain 'L' and (resid 486 through 704 )
chain 'L' and (resid 705 through 756 )
scanning transmission electron microscopy
Influenza A, RNA polymerase, Influenza polymerase, Influenza dimer, RDRP, RNA BINDING PROTEIN
(chain 'A' and (resid 1 through 64 or resid 73 through 373 or resid 376 through 389 or resid 396 through 619 or resid 632 through 714))
(chain 'D' and (resid 1 through 64 or resid 73 through 389 or resid 396 through 550 or resid 556 through 714))
(chain 'G' and (resid 1 through 64 or resid 73 through 373 or resid 376 through 389 or resid 396 through 550 or resid 556 through 619 or resid 632 through 714))
(chain 'J' and (resid 1 through 64 or resid 73 through 373 or resid 376 through 389 or resid 396 through 619 or resid 632 through 714))
(chain 'B' and (resid 1 through 30 or resid 36 through 182 or resid 213 through 223 or resid 244 through 632 or resid 655 through 665 or resid 684 through 756))
(chain 'E' and (resid 1 through 223 or resid 244 through 665 or resid 684 through 756))
(chain 'H' and (resid 1 through 182 or resid 213 through 223 or resid 244 through 632 or resid 655 through 665 or resid 684 through 756))
(chain 'K' and (resid 1 through 182 or resid 213 through 223 or resid 244 through 632 or resid 655 through 756))
(chain 'C' and (resid 1 through 79 or resid 89 through 247 or resid 252 through 418 or resid 430 through 752))
(chain 'F' and (resid 1 through 79 or resid 89 through 247 or resid 252 through 418 or resid 430 through 752))
(chain 'I' and (resid 1 through 79 or resid 89 through 175 or resid 183 through 247 or resid 252 through 418 or resid 430 through 752))
(chain 'L' and (resid 1 through 175 or resid 183 through 752))

MDVNPTLLFLKVPAQNAISTTFPYTGDPPYSHGTGTGYTMDTVNRTHQYSEKGKWTTNTETGAPQLNPIDGPLPEDNEPS
GYAQTDCVLEAMAFLEESHPGIFENSCLETMEVVQQTRVDRLTQGRQTYDWTLNRNQPAATALANTIEVFRSNGLTANES
GRLIDFLKDVMESMDKEEMEITTHFQRKRRVRDNMTKKMVTQRTIGKKKQRVNKRSYLIRALTLNTMTKDAERGKLKRRA
IATPGMQIRGFVYFVETLARSICEKLEQSGLPVGGNEKKAKLANVVRKMMTNSQDTELSFTITGDNTKWNENQNPRMFLA
MITYITKNQPEWFRNVLSIAPIMFSNKMARLGKGYMFESKSMKLRTQIPAEMLASIDLKYFNESTRKKIEKIRPLLIDGT
ASLSPGMMMGMFNMLSTVLGVSILNLGQKRYTKTTYWWDGLQSSDDFALIVNAPNHEGIQAGVDRFYRTCKLVGINMSKK
KSYINRTGTFEFTSFFYRYGFVANFSMELPSFGVSGINESADMSIGVTVIKNNMINNDLGPATAQMALQLFIKDYRYTYR
CHRGDTQIQTRRSFELEKLWEQTRSKAGLLVSDGGPNLYNIRNLHIPEVCLKWELMDEDYQGRLCNPLNPFVSHKEIESV
NNAVVMPAHGPAKSMEYDAVATTHSWIPKRNRSILNTSQRGILEDEQMYQKCCNLFEKFFPSSSYRRPVGISSMVEAMVS
RARIDARIDFESGRIKKEEFAEIMKICSTIEELRRQK

MERIKELRNLMSQSRTREILTKTTVDHMAIIKKYTSGRQEKNPSLRMKWMMAMKYPITADKRITEMVPERNEQGQTLWSK
MSDAGSDRVMVSPLAVTWWNRNGPMTSTVHYPKVYKTYFEKVERLKHGTFGPVHFRNQVKIRRRVDINPGHADLSAKEAQ
DVIMEVVFPNEVGARILTSESQLTITKEKKEELQDCKISPLMVAYMLERELVRKTRFLPVAGGTSSVYIEVLHLTQGTCW
EQMYTPGGEVRNDDVDQSLIIAARNIVRRAAVSADPLASLLEMCHSTQIGGTRMVDILRQNPTEEQAVDICKAAMGLRIS
SSFSFGGFTFKRTSGSSIKREEELLTGNLQTLKIRVHDGYEEFTMVGKRATAILRKATRRLVQLIVSGRDEQSVAEAIIV
AMVFSQEDCMIKAVRGDLNFVNRANQRLNPMHQLLRHFQKDAKVLFQNWGIEHIDNVMGMIGVLPDMTPSTEMSMRGIRV
SKMGVDEYSSTERVVVSIDRFLRVRDQRGNVLLSPEEVSETQGTEKLTITYSSSMMWEINGPESVLVNTYQWIIRNWETV
KIQWSQNPTMLYNKMEFEPFQSLVPKAIRGQYSGFVRTLFQQMRDVLGTFDTTQIIKLLPFAAAPPKQSRMQFSSLTVNV
RGSGMRILVRGNSPAFNYNKTTKRLTILGKDAGTLIEDPDEGTSGVESAVLRGFLILGKEDRRYGPALSINELSNLAKGE
KANVLIGQGDVVLVMKRKRDSSILTDSQTATKRIRMAIN