Nterminal domain of human SMU1 in complex with LSP641

Destabilization of the human RED-SMU1 splicing complex as a basis for host-directed antiinfluenza strategy.

Smu-1 suppressor of mec-8 and unc-52 protein homolog

MGSIEIESSDVIRLIMQYLKENSLHRALATLQEETTVSLNTVDSIESFVADINSGHWDTVLQAIQSLKLPDKTLIDLYEQ
VVLELIELRELGAARSLLRQTDPMIMLKQTQPERYIHLENLLARSYFDPREAYPDGSSKEKRRAAIAQALAGEVSVVPPS
RLMALLGQALKWQQHQGLLPPGMTIDLFRGKAAVKDV

0.1 M Bis-Tris pH 6, 16-20 % PEG 10K, 0.2 M ammonium acetate

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS

Splicing factor, influenza virus, SPLICING

SIEIESSDVIRLIMQYLKENSLHRALATLQEETTVSLNTVDSIESFVADINSGHWDTVLQAIQSLKLPDKTLIDLYEQVV
LELIELRELGAARSLLRQTDPMIMLKQTQPERYIHLENLLARSYFDPREAYPDGSSKEKRRAAIAQALAGEVSVVPPSRL
MALLGQALKWQQHQGLLPPGMTIDLFRGKAAVKDV