HIV-1 Protease NL4-3 K45I, M46I, V82F, I84V Mutant in complex with darunavir

Picomolar to Micromolar: Elucidating the Role of Distal Mutations in HIV-1 Protease in Conferring Drug Resistance.

PQITLWKRPLVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPIIIGGIGGFIKVRQYDQILIEICGHKAIGTVLVGPT
PFNVIGRNLLTQIGCTLNF

19-26% (w/v) Ammonium Sulfate, 0.1M Bis-Tris-Methane-HCl Buffer pH 5.5

National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)

HIV, NL4-3 PROTEASE, DRUG RESISTANCE, PROTEASE INHIBITOR, HYDROLASE INHIBITOR COMPLEX, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR complex

PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYDQILIEICGHKAIGTVLVGPT
PVNVIGRNLLTQIGCTLNF