1.90 A resolution structure of WT BfrB from Pseudomonas aeruginosa in complex with a protein-protein interaction inhibitor (analog 15)

Small Molecule Inhibitors of the BfrB-Bfd Interaction Decrease Pseudomonas aeruginosa Fitness and Potentiate Fluoroquinolone Activity.

MKGDKKVIQHLNKILGNELIAINQYFLHSRMWNDWGLKRLGAHEYHESIDEMKHADKLIERILFLEGLPNLQDLGKLLIG
ENTQEMLQCDLNLELKATKDLREAIVHCEQVHDYVSRDLLKDILESEEEHIDYLETQLGLIQKVGLENYLQSHMHEDD

Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)

30% (v/v) PEG 200, 0.1M sodium acetate, 0.1M NaCl

National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID)

National Science Foundation (NSF, United States)

National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)

ELECTRON TRANSPORT, IRON STORAGE, IRON BINDING, IRON MOBILIZATION, PROTEIN-PROTEIN INTERACTION INHIBITOR, OXIDOREDUCTASE