Crystal structure of HIV-1 broadly neutralizing antibody ACS202

Conformational Plasticity in the HIV-1 Fusion Peptide Facilitates Recognition by Broadly Neutralizing Antibodies.

QVQLVESGGGVVQPGGSLRLSCAASGFAFKDFGMHWVRQAPGKGLEWVAVIGGGHGQHQSYSESVKGRFAITRDNEKNKL
YLHMDRLRTEDTAVYYCAKDRLGRPWNIGGRLVYYYYGMDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCL
VKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCD

AIRMTQSPSSLSASVGDRVTITCQASQDIKKSLNWYRQKPGKAPELLIHDASILQTGVPSAFTASGSGTHFSFVINKLQP
EDVGTYFCQEYENLQFTFGPGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQ
ESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC

1.6 M ammonium sulfate, 0.1 M bicine, pH8.7

antibody, HIV, envelope glycoprotein, fusion peptide, IMMUNE SYSTEM

(chain C and (resid 1 through 133 or resid 135 through 213))