Crystal Structure of Human PPARgamma Ligand Binding Domain in Complex with GW9662 and Arachidonic acid

Cooperative cobinding of synthetic and natural ligands to the nuclear receptor PPAR gamma.

Peroxisome proliferator-activated receptor gamma

PPAR-gamma,Nuclear receptor subfamily 1 group C member 3

QLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIF
QGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGD
FMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDL
RQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY

National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Disease (NIH/NIDDK)

Nuclear receptors, TZDs, Drug design, Therapeutic targets, transcription-transcription inhibitor complex