Crystal Structure of Human Nav1.4 CTerminal Domain in Complex with apo Calmodulin

Ca2+-dependent regulation of sodium channels NaV1.4 and NaV1.5 is controlled by the post-IQ motif.

Sodium channel protein type 4 subunit alpha

SkM1,Sodium channel protein skeletal muscle subunit alpha,Sodium channel protein type IV subunit alpha,Voltage-gated sodium channel subunit alpha Nav1.4

GPLGSENFNVATEESSEPLGEDDFEMFYETWEKFDPDATQFIAYSRLSDFVDTLQEPLRIAKPNKIKLITLDLPMVPGDK
IHCLDILFALTKEVLGDSGEMDALKQTMEEKFMAANPSKVSYEPITTTLKRKHEEVCAIKIQRAYRRHLLQRSMKQASYM
YRHSHDGSGDD

MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLTMMARKMKDT
DSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMTAK

National Institutes of Health/National Heart, Lung, and Blood Institute (NIH/NHLBI)

chain 'A' and (resid 1612 through 1688 )

chain 'A' and (resid 1691 through 1706 )

chain 'A' and (resid 1714 through 1748 )

SCN4A, voltage gated sodium channel, calmodulin, MEMBRANE PROTEIN, CALMODULIN-BINDING PROTEIN

ENFNVATEESSEPLGEDDFEMFYETWEKFDPDATQFIAYSRLSDFVDTLQEPLRIAKPNKIKLITLDLPMVPGDKIHCLD
ILFALTKEVLGDSGEMDALKQTMEEKFMAANPSKVSYEPITTTLKRKHEEVCAIKIQRAYRRHLLQRSMKQASYMYRHSH
DGSGDD