Crystal structure of p53/BCL-xL fusion complex

Structural insight into the molecular mechanism of p53-mediated mitochondrial apoptosis.

fusion protein of Bcl-2-like protein 1 and Isoform 6 of Cellular tumor antigen p53

Bcl2-L-1,Apoptosis regulator Bcl-X,Antigen NY-CO-13,Phosphoprotein p53,Tumor suppressor p53

GPSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTA
YQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYGNNA
AAGGGGSLVPRGSGGGGSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRV
RAMAIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYM
CNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRKK

0.2M sodium malonate pH 7.0, 20%(w/v) polyethylene glycol 3,350

National Natural Science Foundation of China (NSFC)

SQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLADSPAVNGATGHSSSLDAREVI
PMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQV
LVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYGNNAAA

SVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRR
CPHHERCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILTII
TLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRKK